Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(8), P. 495 - 506
Published: June 16, 2023
Language: Английский
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4084 - 4097
Published: Aug. 22, 2023
Dementia is a leading cause of disability and death worldwide. At present there no disease modifying treatment for any the most common types dementia such as Alzheimer's (AD), Vascular dementia, Lewy Body (LBD) Frontotemporal (FTD). Early accurate diagnosis subtype critical to improving clinical care developing better treatments. Structural molecular imaging has contributed understanding pathophysiology neurodegenerative dementias increasingly being adopted into practice early diagnosis. In this review we summarise contribution made with particular focus on multimodal magnetic resonance (MRI) positron emission tomography (PET). MRI widely used in can help exclude reversible causes memory problems but relatively low sensitivity differential subtypes.
Language: Английский
Citations
51
Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 567 - 588
Published: June 25, 2024
Language: Английский
Citations
24
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 13, 2024
Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) are sensitive markers of neuroinflammation neuronal damage. Previous studies with highly selected participants have shown that peripheral GFAP NfL levels elevated in the pre-clinical phase Alzheimer's disease (AD) dementia. However, predictive value for dementia requires more evidence from population-based cohorts.
Language: Английский
Citations
21
Brain Research, Journal Year: 2024, Volume and Issue: 1829, P. 148797 - 148797
Published: Feb. 10, 2024
Language: Английский
Citations
14
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Sept. 4, 2024
Language: Английский
Citations
14
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474
Published: March 7, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7621 - 7621
Published: July 11, 2024
Multiple organs and tissues coordinate to respond dietary environmental challenges. It is interorgan crosstalk that contributes systemic metabolic homeostasis. The liver brain, as key organs, have their unique dialogue transmit messages. interconnected pathogenesis of brain implicated in numerous neurodegenerative disorders. Recent insights positioned the not only a central hub but also an endocrine organ, capable secreting hepatokines signals throughout body via bloodstream. Metabolites from or gut microbiota facilitate complex between brain. In parallel humoral factors, neural pathways, particularly hypothalamic nuclei autonomic nervous system, are pivotal modulating bilateral interplay cerebral hepatic compartments. term “liver–brain axis” vividly portrays this interaction. At end review, we summarize cutting-edge technical advancements enabled observation manipulation these signals, including genetic engineering, molecular tracing, delivery technologies. These innovations paving way for deeper understanding liver–brain axis its role
Language: Английский
Citations
8
Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(2)
Published: Feb. 1, 2025
Astrocytes are glial cells recognized for their diverse roles in regulating brain circuit structure and function. They can sense adapt to changes the microenvironment due unique structural biochemical properties. A key aspect of astrocytic function involves calcium (Ca2+)-dependent signaling, which serves as a fundamental mechanism interactions with neurons other brain. However, while significant progress has been made understanding spatio-temporal properties Ca2+ signals, downstream molecular pathways exact mechanisms through astrocytes decode these signals regulate homeostatic physiological processes remain poorly understood. To address this topic, we review here available literature on sources intracellular Ca2+, well its signaling pathways. We well-studied Ca2+-dependent exocytosis but draw attention additional that less understood are, most likely, highly influential many cellular functions. Finally, how is thought underlie neuron-astrocyte regions involved cognitive processing.
Language: Английский
Citations
1
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(8)
Published: Feb. 13, 2024
Accumulating evidence suggests that the brain renin angiotensin system (RAS) plays a pivotal role in regulation of cognition and behavior as well neuropathology neurological mental disorders. The II type 1 receptor (AT1R) mediates most functional neuropathology-relevant actions associated with central RAS. However, an overarching comprehension to guide translation utilize therapeutic potential RAS humans is currently lacking. We conducted comprehensive characterization using innovative combination transcriptomic gene expression mapping, image-based behavioral decoding, pre-registered randomized controlled discovery–replication pharmacological resting-state magnetic resonance imaging (fMRI) trials (N = 132) selective AT1R antagonist. exhibited particular dense subcortical network encompassing thalamus, striatum, amygdalo-hippocampal formation. Behavioral decoding map showed association memory, stress, reward, motivational processes. Transient blockade further decreased neural activity systems characterized by high expression, while increasing connectivity cortico-basal ganglia-thalamo-cortical circuitry. Effects on level were specifically signatures dopaminergic, opioid, acetylcholine, corticotropin-releasing hormone signaling systems. robustness results was supported independent fMRI trial. These findings present biologically informed pathways their relevance humans.
Language: Английский
Citations
6
Cells, Journal Year: 2023, Volume and Issue: 12(11), P. 1469 - 1469
Published: May 24, 2023
Reactive astrogliosis is an early event in the continuum of Alzheimer’s disease (AD). Current advances positron emission tomography (PET) imaging provide ways assessing reactive living brain. In this review, we revisit clinical PET and vitro findings using multi-tracer approach, point out that precedes deposition Aβ plaques, tau pathology, neurodegeneration AD. Furthermore, considering current view heterogeneity—more than one subtype astrocyte involved—in AD, discuss how astrocytic body fluid biomarkers might fit into trajectories different from imaging. Future research focusing on development innovative radiotracers may further insights heterogeneity improve detection AD its stages.
Language: Английский
Citations
13