Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 7, 2022
Abstract
Checkpoint
blockade
with
Pembrolizumab,
has
demonstrated
durable
clinical
responses
in
advanced
non-small
cell
lung
cancer,
however,
treatment
is
offset
by
the
development
of
high-grade
immune
related
adverse
events
(irAEs)
some
patients.
Here,
we
show
that
these
patients
a
deficient
Breg
checkpoint
fails
to
limit
self-reactive
T
enhanced
activity
and
auto-antibody
formation
enabled
PD-1/PD-L1
blockade,
leading
severe
auto-inflammatory
sequelae.
Principally
failure
IL-10
producing
regulatory
B
cells
as
through
functional
ex
vivo
assays
deep
phenotyping
mass
cytometric
analysis,
major
significant
finding
who
develop
irAEs
when
undergoing
anti-PD1/PD-L1
blockade.
There
currently
lack
biomarkers
identify
priori
those
at
greatest
risk
developing
syndrome.
Pre-therapy
profiling
could
provide
an
important
tool
cancer
high
on
Annual Review of Immunology,
Journal Year:
2021,
Volume and Issue:
39(1), P. 51 - 76
Published: Jan. 11, 2021
T
lymphocytes,
the
major
effector
cells
in
cellular
immunity,
produce
cytokines
immune
responses
to
mediate
inflammation
and
regulate
other
types
of
cells.
Work
last
three
decades
has
revealed
significant
heterogeneity
CD4+
cells,
terms
their
cytokine
expression,
leading
discoveries
helper
1
(Th1),
Th2,
Th17,
follicular
(Tfh)
cell
subsets.
These
possess
unique
developmental
regulatory
pathways
play
distinct
roles
immunity
immune-mediated
pathologies.
Other
including
γδ
as
well
innate
display
similar
features
subpopulations,
which
may
differential
immunity.
Mechanisms
exist
prevent
production
by
maintain
tolerance
self-antigens,
some
also
underscore
exhaustion
context
tumors.
Understanding
regulation
function
offered
innovative
treatment
many
human
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 19, 2023
T
cells
are
crucial
for
immune
functions
to
maintain
health
and
prevent
disease.
cell
development
occurs
in
a
stepwise
process
the
thymus
mainly
generates
CD4
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(21), P. 8011 - 8011
Published: Oct. 28, 2020
The
immune
system
plays
a
critical
role
in
protecting
hosts
from
the
invasion
of
organisms.
CD4
T
cells,
as
key
component
system,
are
central
orchestrating
adaptive
responses.
After
decades
investigation,
five
major
helper
cell
(Th)
subsets
have
been
identified:
Th1,
Th2,
Th17,
Treg
(T
regulatory),
and
Tfh
(follicular
helper)
cells.
Th1
defined
by
expression
lineage
cytokine
interferon
(IFN)-γ
master
transcription
factor
T-bet,
participate
type
1
responses
to
intracellular
pathogens
such
mycobacterial
species
viruses;
Th2
cytokines
interleukin
(IL)-4/IL-5/IL-13
GAΤA3,
2
larger
extracellular
helminths;
Th17
IL-17/IL-22
RORγt,
3
including
some
bacteria
fungi;
producing
IL-21
expressing
Bcl6,
help
B
cells
produce
corresponding
antibodies;
whereas
Foxp3-expressing
unlike
Th1/Th2/Th17/Tfh
exerting
their
effector
functions,
regulate
maintain
homeostasis
prevent
immunopathology.
Interestingly,
innate
lymphoid
(ILCs)
found
mimic
functions
three
(Th1,
Th17)
thus
can
also
be
divided
into
subsets:
ILC1s,
ILC2s,
ILC3s.
In
this
review,
we
will
discuss
differentiation
each
subset
context
ILCs
human
diseases
associated
with
dysregulation
these
lymphocyte
particularly
caused
monogenic
mutations.
Allergy,
Journal Year:
2020,
Volume and Issue:
76(2), P. 456 - 470
Published: Oct. 24, 2020
Abstract
Allergic
diseases
are
characterized
by
overactive
type
2
immune
responses
to
allergens
and
immunoglobulin
E
(IgE)‐mediated
hypersensitivity.
Emerging
evidence
suggests
that
follicular
helper
T
(T
FH
)
cells,
rather
than
T‐helper
H
2)
play
a
crucial
role
in
controlling
IgE
production.
However,
regulatory
FR
specialized
subset
of
REG
cells
resident
B‐cell
follicles,
restricts
cell‐mediated
help
extrafollicular
antibody
production,
germinal
center
(GC)
formation,
affinity
maturation,
long‐lived,
high‐affinity
plasma
memory
differentiation.
In
mouse
models
allergic
asthma
food
allergy,
CXCR5
+
not
−
conventional
needed
support
otherwise
exacerbated
cell
deletion.
Upregulation
activities,
including
skewing
toward
IL‐13
producing
13)
phenotypes,
defects
have
been
identified
patients
with
diseases.
Allergen
immunotherapy
(AIT)
reinstates
the
balance
between
diseases,
resulting
clinical
benefits.
Collectively,
further
understanding
their
immunopathogenesis
creates
opportunities
develop
novel
therapeutic
approaches.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(23), P. 6021 - 6021
Published: Nov. 29, 2019
Systemic
lupus
erythematosus
(SLE)
is
an
autoimmune
disease
characterized
by
excessive
autoantibody
production
and
multi-organ
involvement.
Although
the
etiology
of
SLE
still
remains
unclear,
recent
studies
have
several
pathogenic
B
cell
subsets
regulatory
involved
in
pathogenesis
SLE.
Among
subsets,
age-associated
cells
(ABCs)
are
a
newly
identified
subset
autoreactive
with
T-bet-dependent
transcriptional
programs
unique
functional
features
Accumulation
T-bet+
CD11c+
ABCs
has
been
observed
patients
mouse
models.
In
addition,
innate-like
receptor
(BCR)
expression
long-lived
plasma
persistent
contribute
to
development
Moreover,
immune
suppressive
functions
identified,
while
impaired
inhibitory
effects
indicated
Thus,
further
elucidation
on
will
provide
new
insights
understanding
lead
novel
therapeutic
interventions
treatment
