Hallmarks of Cancer: New Dimensions

Cancer Discovery, Journal Year: 2022, Volume and Issue: 12(1), P. 31 - 46

Published: Jan. 1, 2022

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity phenotypes and genotypes into provisional set underlying principles. As knowledge mechanisms has progressed, other facets disease have emerged as potential refinements. Herein, prospect raised that phenotypic plasticity disrupted differentiation discrete hallmark capability, nonmutational epigenetic reprogramming polymorphic microbiomes both constitute distinctive enabling characteristics facilitate acquisition capabilities. Additionally, senescent cells, varying origins, may be added to roster functionally important cell types in tumor microenvironment. SIGNIFICANCE: Cancer daunting breadth scope its diversity, spanning genetics, tissue biology, pathology, response therapy. Ever more powerful experimental computational tools technologies are providing an avalanche "big data" about myriad manifestations diseases encompasses. integrative concept embodied helping distill this increasingly logical science, new dimensions presented perspective add value endeavor, fully understand development malignant progression, apply medicine.

Language: Английский

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The microbiome and human cancer

Science, Journal Year: 2021, Volume and Issue: 371(6536)

Published: March 25, 2021

Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies provocatively claimed that bacteria, viruses, and/or fungi are pervasive among cancers, key actors immunotherapy, engineerable to treat metastases. Despite these findings, the number of microbes known directly cause carcinogenesis remains small. Critically evaluating building frameworks such evidence light modern biology is an important task. In this Review, we delineate between causal complicit trace common themes their influence through host's immune system, herein defined as immuno-oncology-microbiome axis. We further review intratumoral approaches manipulate gut or tumor microbiome while projecting next phase experimental discovery.

Language: Английский

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The inflammatory pathogenesis of colorectal cancer

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(10), P. 653 - 667

Published: April 28, 2021

Language: Английский

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Role and Mechanism of Gut Microbiota in Human Disease

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: March 17, 2021

The human gut microbiome is a huge microbial community that plays an irreplaceable role in life. With the further development of research, influence intestinal flora on diseases has been gradually excavated. Gut microbiota (GM) dysbiosis adverse health effects body will lead to variety chronic diseases. underlying mechanisms GM are incredibly complicated. This review focuses regulation and mechanism neurodegenerative diseases, cardiovascular metabolic gastrointestinal thus providing potential target for prevention treatment disease.

Language: Английский

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Microbiome and cancer

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(10), P. 1317 - 1341

Published: Sept. 9, 2021

Language: Английский

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Genetic and biological hallmarks of colorectal cancer

Genes & Development, Journal Year: 2021, Volume and Issue: 35(11-12), P. 787 - 820

Published: June 1, 2021

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, these insights have illuminated early detection, risk stratification, prevention, treatment principles. Employing hallmarks framework, we provide conceptual framework to understand how alterations in colorectal drive cell biology properties shape heterotypic interactions across cells tumor microenvironment. This review details research advances pertaining genetics cancer, emerging concepts gleaned from immune single-cell profiling, critical remaining knowledge gaps influencing development effective therapies this that remains major public health burden.

Language: Английский

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High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites

Gastroenterology, Journal Year: 2021, Volume and Issue: 162(1), P. 135 - 149.e2

Published: Aug. 27, 2021

Language: Английский

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Gut microbiota in colorectal cancer development and therapy

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(7), P. 429 - 452

Published: May 11, 2023

Language: Английский

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Molecular targeted therapy for anticancer treatment

Experimental & Molecular Medicine, Journal Year: 2022, Volume and Issue: 54(10), P. 1670 - 1694

Published: Oct. 12, 2022

Abstract Since the initial clinical approval in late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served a fundamental backbone precision medicine cancer treatment. These approaches are now used clinically first-line various human cancers. Compared to conventional chemotherapy, have efficient with fewer side effects. However, emergence drug resistance is major drawback therapy, several strategies been attempted improve efficacy by overcoming such resistance. Herein, we summarize current knowledge regarding agents, including classification, brief biology target kinases, mechanisms action, examples perspectives future development.

Language: Английский

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p53 and Tumor Suppression: It Takes a Network

Trends in Cell Biology, Journal Year: 2021, Volume and Issue: 31(4), P. 298 - 310

Published: Jan. 28, 2021

Language: Английский

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