Leukemia, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 25, 2024
Language: Английский
Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 727 - 736
Published: Feb. 21, 2024
Language: Английский
Citations
140
Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(9), P. 709 - 722
Published: July 4, 2024
Language: Английский
Citations
61
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 18, 2024
Abstract Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis aging coincide because both are driven by time, irrespective of the precise causes, can be confronted with idea share common mechanistic grounds referred to as ‘hallmarks’. Indeed, several hallmarks also contribute carcinogenesis tumor progression, but some molecular cellular characteristics may reduce probability developing lethal cancer, perhaps explaining why very old age (> 90 years) is accompanied a reduced incidence neoplastic diseases. We discuss possibility process itself causes meaning time-dependent degradation supracellular functions accompanies produces byproduct or ‘age-associated disease’. Conversely, its treatment erode health drive process, has dramatically been documented for survivors diagnosed during childhood, adolescence, young adulthood. conclude connected superior including endogenous lifestyle factors, well bidirectional crosstalk, together render not only risk factor an important parameter must considered therapeutic decisions.
Language: Английский
Citations
47
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116203 - 116203
Published: Jan. 26, 2024
Tumor immunotherapy, an innovative anti-cancer therapy, has showcased encouraging outcomes across diverse tumor types. Among these, the PD-1/PD-L1 signaling pathway is a well-known immunological checkpoint, which significant in regulation of immune evasion by tumors. Nevertheless, considerable number patients develop resistance to anti-PD-1/PD-L1 rendering it ineffective long run. This research focuses on exploring factors PD-1/PD-L1-mediated immunotherapy. Initially, characterized its role facilitating evasion, emphasizing autoimmune homeostasis. Next, primary mechanisms PD-1/PD-L1-based immunotherapy are analyzed, including antigen deletion, T cell dysfunction, increased immunosuppressive cells, and alterations expression PD-L1 within cells. The possible ramifications altered metabolism, microbiota, DNA methylation also described. Finally, resolution strategies for dealing with discussed, placing particular emphasis personalized therapeutic approaches exploration more potent regimens.
Language: Английский
Citations
38
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: June 4, 2024
Abstract Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant type tumor have remained grim long time. Currently, it extremely challenging to prevent or detect early enough effective treatment because patients rarely exhibit symptoms there are no reliable indicators detection. Most advanced spreading that difficult treat, treatments like chemotherapy radiotherapy can only slightly prolong their life by few months. Immunotherapy has revolutionized pancreatic cancer, yet its effectiveness limited tumor's immunosuppressive hard-to-reach microenvironment. First, article explains microenvironment highlights wide range immunotherapy options, including therapies involving oncolytic viruses, modified T cells (T-cell receptor [TCR]-engineered chimeric antigen [CAR] T-cell therapy), CAR natural killer cell therapy, cytokine-induced cells, immune checkpoint inhibitors, immunomodulators, vaccines, strategies targeting myeloid in context contemporary knowledge future trends. Lastly, discusses main challenges ahead immunotherapy.
Language: Английский
Citations
34
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 14, 2024
Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract
Language: Английский
Citations
25
Cell, Journal Year: 2024, Volume and Issue: 187(11), P. 2633 - 2651
Published: May 1, 2024
Cell states were traditionally defined by how they looked, where located, and what functions performed. In this post-genomic era, the field is largely focused on a molecular view of cell state. Moving forward, we anticipate that observables used to define will evolve again as single-cell imaging analytics are advancing at breakneck pace via collection large-scale, systematic image datasets application quantitative image-based data science methods. This is, therefore, key moment in arc biological research develop approaches integrate spatiotemporal physical structure organization with toward concept holistic perspective, propose conceptual framework for state transitions data-driven, practical, useful enable integrative analyses modeling across many types.
Language: Английский
Citations
24
Nature Immunology, Journal Year: 2024, Volume and Issue: 25(8), P. 1344 - 1354
Published: July 18, 2024
Language: Английский
Citations
23
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 406 - 418
Published: April 12, 2024
T cells modified to express intelligently designed chimeric antigen receptors (CARs) are exceptionally powerful therapeutic agents for relapsed and refractory blood cancers have the potential revolutionize therapy many other diseases. To circumvent complexity cost associated with broad-scale implementation of ex vivo manufactured adoptive cell products, alternative strategies generate CAR in by direct infusion nanoparticle-formulated nucleic acids or engineered viral vectors under development received a great deal attention past few years. Here, we outline manufacturing process as motivating framework discuss emerging data from preclinical models highlight potency approach, applicability new disease indications, remaining challenges clinical readiness, including delivery specificity, long term efficacy, safety.
Language: Английский
Citations
21
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 4, 2024
Abstract This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent vitro. Cellular senescence contributes to age-related tissue decline is characterized by permanent cell cycle arrest senescence-associated secretory phenotype (SASP). Immunotherapy, particularly CAR-T therapy, emerges as a promising approach selectively eliminate cells. Our focus on receptor, which binds ligands (NKG2DLs) upregulated cells, offering target for Using mouse embryonic fibroblasts (MEFs) astrocytes (AST) models, we demonstrate elevated expression NKG2DLs response genotoxic oxidative stress. NKG2D-CAR displayed potent cytotoxicity against these with minimal effects non-senescent suggesting their potential targeted senolytics. In conclusion, our research presents first evidence cells’ ability brain novel manage diseases. The findings pave way future investigations into therapeutic applicability NKG2D-targeting naturally aged organisms models aging-associated diseases vivo.
Language: Английский
Citations
19