Ongoing movement controls sensory integration in the dorsolateral striatum DOI Creative Commons
Roberto de la Torre‐Martínez, Maya Ketzef, Gilad Silberberg

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 22, 2023

Abstract The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, responses are affected by activity, however, it is not known whether such sensorimotor interactions occur in how they shaped dopamine. To determine impact of activity on striatal processing, we performed vivo whole-cell recordings DLS awake mice during presentation tactile stimuli. Striatal medium spiny neurons (MSNs) were activated whisker stimulation spontaneous whisking, their to deflection ongoing whisking attenuated. Dopamine depletion reduced representation direct-pathway MSNs, but those indirect-pathway. Furthermore, dopamine impaired discrimination between ipsilateral contralateral direct indirect pathway MSNs. Our results show that affects processes dopamine- cell type-dependent.

Language: Английский

Networking brainstem and basal ganglia circuits for movement DOI
Silvia Arber, Rui M. Costa

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(6), P. 342 - 360

Published: April 14, 2022

Language: Английский

Citations

138
Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms DOI Creative Commons
Larissa Albantakis,

Leonardo Barbosa,

Graham Findlay

et al.

PLoS Computational Biology, Journal Year: 2023, Volume and Issue: 19(10), P. e1011465 - e1011465

Published: Oct. 17, 2023

This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies essential (axioms), infers necessary and sufficient that its substrate must satisfy (postulates), expresses them mathematical In principle, postulates can be applied any system units a state determine whether it is conscious, what degree, way. offers parsimonious explanation empirical evidence, makes testable predictions concerning both presence quality experience, permits inferences extrapolations. 4.0 incorporates several developments past ten years, including more accurate formulation axioms as expressions, introduction unique measure intrinsic information consistent with postulates, an explicit assessment causal relations. By fully unfolding system's irreducible cause-effect power, distinctions relations specified by experience.

Language: Английский

Citations

124
Dopamine transients follow a striatal gradient of reward time horizons DOI Creative Commons
Ali Mohebi, Wei Wei,

Lilian Pelattini

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 737 - 746

Published: Feb. 6, 2024

Abstract Animals make predictions to guide their behavior and update those through experience. Transient increases in dopamine (DA) are thought be critical signals for updating predictions. However, it is unclear how this mechanism handles a wide range of behavioral timescales—from seconds or less (for example, if singing song) potentially hours more hunting food). Here we report that DA transients distinct rat striatal subregions convey prediction errors based on time horizons. dynamics systematically accelerated from ventral dorsomedial dorsolateral striatum, the tempo spontaneous fluctuations, temporal integration prior rewards discounting future rewards. This spectrum timescales evaluative computations can help achieve efficient learning adaptive motivation broad behaviors.

Language: Английский

Citations

40
Organization of the inputs and outputs of the mouse superior colliculus DOI Creative Commons
Nora L. Benavidez, Michael S. Bienkowski, Muye Zhu

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: June 28, 2021

The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive sensorimotor behaviors. However, it remains unclear how descending input arising from higher-order associative areas coordinate with SC networks influence its outputs. Here, we construct comprehensive map all cortico-tectal projections identify four collicular zones differential inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) lateral (SC.l). Further, delineate the distinctive brain-wide input/output organization each zone, assemble multiple parallel cortico-tecto-thalamic subnetworks, somatotopic in that displays distinguishable spatial properties maps neocortex basal ganglia. Finally, characterize interactions between those cortico-basal ganglia-thalamic subnetworks. This study provides structural basis for understanding is involved integrating different sensory modalities, translating information motor command, coordinating actions goal-directed

Language: Английский

Citations

103
Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition DOI Creative Commons
Xiao‐Jing Wang

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 533 - 560

Published: July 8, 2022

The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable rigorous research. Here, I review recent experimental theoretical on the modus operandi of multiregional cortex. These studies revealed several general principles for neocortical interareal connectivity, low-dimensional macroscopic gradients biological properties across cortical areas, hierarchy timescales information processing. Theoretical suggests testable predictions regarding differential excitation inhibition along feedforward feedback pathways in hierarchy. Furthermore, modeling distributed working memory simple decision-making given rise novel mathematical concept, dubbed bifurcation space, that potentially explains how different canonical circuit organization but heterogeneities, are able their respective (e.g., sensory coding versus executive control) functions modularly organized brain.

Language: Английский

Citations

58
Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective DOI Creative Commons
Charles R. Gerfen

Frontiers in Synaptic Neuroscience, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 19, 2023

The direct and indirect striatal pathways form a cornerstone of the circuits basal ganglia. Dopamine has opponent affects on function these due to segregation D1- D2-dopamine receptors in spiny projection neurons giving rise pathways. An historical perspective is provided discovery dopamine receptor leading models how affect motor behavior.

Language: Английский

Citations

39
Neural mechanisms of domain-general inhibitory control DOI
Jan R. Wessel, Michael C. Anderson

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 28(2), P. 124 - 143

Published: Oct. 26, 2023

Language: Английский

Citations

37
Local and long-distance organization of prefrontal cortex circuits in the marmoset brain DOI Creative Commons
Akiya Watakabe, Henrik Skibbe, Ken Nakae

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(14), P. 2258 - 2273.e10

Published: May 16, 2023

The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC found two contrasting corticocortical corticostriatal projection patterns: "patchy" projections that formed many columns submillimeter scale nearby distant "diffuse" spread widely across striatum. Parcellation-free analyses revealed representations gradients these projections' local global distribution patterns. also demonstrated column-scale precision reciprocal connectivity, suggesting contains a mosaic discrete columns. Diffuse showed considerable diversity laminar patterns axonal spread. Altogether, fine-grained reveal important principles long-distance circuits marmosets provide insights into functional primate brain.

Language: Английский

Citations

35
Structural and functional map for forelimb movement phases between cortex and medulla DOI Creative Commons
Wuzhou Yang, Harsh Kanodia, Silvia Arber

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(1), P. 162 - 177.e18

Published: Jan. 1, 2023

The cortex influences movement by widespread top-down projections to many nervous system regions. Skilled forelimb movements require brainstem circuitry in the medulla; however, logic of cortical interactions with these neurons remains unexplored. Here, we reveal a fine-grained anatomical and functional map between anterior (AC) medulla mice. Distinct regions generate three-dimensional synaptic columns tiling lateral medulla, topographically matching dorso-ventral positions postsynaptic tuned distinct action phases. Although medial AC (MAC) terminates ventrally connects forelimb-reaching-tuned its silencing impairs reaching, (LAC) dorsally positioned food handling, handling. Cortico-medullary also extend collaterals other subcortical structures through segregated channel interaction logic. Our findings precise alignment location, function, specific forelimb-action-tuned neurons, thereby clarifying principles two key beyond.

Language: Английский

Citations

29
Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action DOI Creative Commons
Ann M. Graybiel, A. Matsushima

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 359 - 380

Published: April 18, 2023

Striosomes form neurochemically specialized compartments of the striatum embedded in a large matrix made up modules called matrisomes. Striosome-matrix architecture is multiplexed with canonical direct-indirect organization striatum. Striosomal functions remain to be fully clarified, but key information emerging. First, striosomes powerfully innervate nigral dopamine-containing neurons and can completely shut down their activity, following rebound excitation. Second, receive limbic cognition-related corticostriatal afferents are dynamically modulated relation value-based actions. Third, spatially interspersed among matrisomes interneurons influenced by local global neuromodulatory oscillatory activities. Fourth, tune engagement motivation perform reinforcement learning, manifest stereotypical behaviors, navigate valence conflicts discriminations. We suggest that, at an algorithmic level, could serve as distributed scaffolds provide formats striatal computations generated through development refined learning. propose that affect subjective states. By transforming corticothalamic other inputs functional striatum, they implement state transitions nigro-striato-nigral circuits bodily cognitive actions according internal motives whose compromised neuropsychiatric conditions.

Language: Английский

Citations

27