Characterization of auditory responsive neurons in the mouse superior colliculus to naturalistic sounds DOI Creative Commons
Yufei Si, Shinya Ito, A. M. Litke

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Locating the source of a specific sound in complex environment and determining its saliency is critical for survival. The superior colliculus (SC), sensorimotor midbrain structure, plays an important role localization has been shown to have topographic map auditory space range species. In mice, previous studies using broadband white noise stimuli found that neurons use high-frequency monaural spectral cues interaural level differences (ILDs) compute spatially restricted receptive fields (RFs), these RFs are organized topographically along azimuth. However, naturalistic environment, animal encounters may rich components; however, sources can still be localized efficiently. It remains unknown whether how SC respond sounds and, turn, RF. Here, we show results from large-scale vivo physiological recordings response noise, ultrasonic pup calls chirps. We find mouse with distinct temporal patterns spatial preference predominantly at ∼60 degrees contralateral addition, categorized based on their spectrotemporal field demonstrated there least 4 subtypes responsive neurons. Significance Statement (SC) receives visual information used localize objects. While organization composition visually well described, much less known about types properties presented calls, chirp mice while recording Analysis neuronal responses defines classes also stimuli, mainly occur when side but not front animal. These lead hypothesis different strategies depending source.

Language: Английский

The physiological control of eating: signals, neurons, and networks DOI

Alan G. Watts,

Scott E. Kanoski,

Graciela Sanchez‐Watts

et al.

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 689 - 813

Published: Sept. 6, 2021

During the past 30 yr, investigating physiology of eating behaviors has generated a truly vast literature. This is fueled in part by dramatic increase obesity and its comorbidities that coincided with an ever increasing sophistication genetically based manipulations. These techniques have produced results remarkable degree cell specificity, particularly at signaling level, played lead role advancing field. However, putting these findings into brain-wide context connects physiological signals neurons to behavior somatic requires thorough consideration neuronal connections: field also seen extraordinary technological revolution. Our goal present comprehensive balanced assessment how associated energy homeostasis interact many brain levels control behaviors. A major theme engage sets interacting neural networks throughout are defined specific connections. We begin discussing some fundamental concepts, including ones still engender vigorous debate, provide necessary frameworks for understanding controls meal initiation termination. include key word definitions, ATP availability as pivotal regulated variable homeostasis, neuropeptide signaling, homeostatic hedonic eating, structure. Within this context, we discuss network models regions endbrain (or telencephalon), hypothalamus, hindbrain, medulla, vagus nerve, spinal cord work together gastrointestinal tract enable complex motor events permit animals eat diverse situations.

Language: Английский

Citations

107
Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice DOI
Kameron K. Clayton, Kamryn S. Stecyk,

Anna Guo

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(8), P. 1605 - 1620.e5

Published: March 15, 2024

Language: Английский

Citations

19
A collicular map for touch-guided tongue control DOI
Brendan S. Ito, Yongjie Gao, Brian Kardon

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

4
The Superior Colliculus: Cell Types, Connectivity, and Behavior DOI Creative Commons
Xue Liu,

Hongren Huang,

Terrance P. Snutch

et al.

Neuroscience Bulletin, Journal Year: 2022, Volume and Issue: 38(12), P. 1519 - 1540

Published: April 28, 2022

Abstract The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor structures where visual, auditory, and somatosensory information are integrated to initiate motor commands, is highly conserved across vertebrate evolution. Moreover, cell-type-specific SC neurons integrate afferent signals within local networks generate defined output related innate cognitive behaviors. This review focuses on recent progress in understanding phenotypic diversity amongst their intrinsic circuits long-projection targets. We further describe relevant neural specific cell types relation behavioral outputs functions. systematic delineation organization, types, connections put into context species as these depend upon laminar architecture. we focus circuitry involving saccadic eye movement, Overall, provides insight functioning represents a basis for pathology associated with dysfunction.

Language: Английский

Citations

55
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons DOI Creative Commons
Jérémie Sibille, Carolin Gehr, Jonathan I. Benichov

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 5, 2022

Abstract The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors mammals. Neurons the receive inputs from retinal ganglion cells but how these are integrated vivo unknown. Here, we discovered high-density electrodes simultaneously capture activity of axons and their postsynaptic target neurons colliculus, vivo. We show cell mouse provide single precise representation retina as input to colliculus. This isomorphic mapping builds scaffold for retinotopic wiring functionally specific connection strength. Our methods broadly applicable, which demonstrate by recording optic tectum zebra finches. find common rules mice finches visual world encoded connections retinorecipient areas.

Language: Английский

Citations

53
How deep is the brain? The shallow brain hypothesis DOI
Mototaka Suzuki, Cyriel M. A. Pennartz, Jaan Aru

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 778 - 791

Published: Oct. 27, 2023

Language: Английский

Citations

40
A guide to the BRAIN Initiative Cell Census Network data ecosystem DOI Creative Commons
Michael Hawrylycz, Maryann E. Martone, Giorgio A. Ascoli

et al.

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(6), P. e3002133 - e3002133

Published: June 30, 2023

Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function cell types in brain. Classification neurons also essential manipulate controlled ways understand their variation vulnerability brain disorders. The BRAIN Initiative Cell Census Network (BICCN) an integrated network data-generating centers, archives, standards developers, with goal systematic multimodal type profiling characterization. Emphasis BICCN on whole mouse demonstration prototype feasibility for human nonhuman primate (NHP) brains. Here, we provide guide spatial approaches employed by BICCN, accessing using these extensive resources, including Data Center (BCDC), which serves manage integrate ecosystem. We illustrate power ecosystem through vignettes highlighting several analysis visualization tools. Finally, present emerging that have been developed or adopted toward Findable, Accessible, Interoperable, Reusable (FAIR) neuroscience. combined provides comprehensive resource exploration

Language: Английский

Citations

32
Inhibitory top-down projections from zona incerta mediate neocortical memory DOI Creative Commons
Anna Schroeder, M. Belén Pardi, Joram Keijser

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(5), P. 727 - 738.e8

Published: Jan. 6, 2023

Top-down projections convey a family of signals encoding previous experiences and current aims to the sensory neocortex, where they converge with external bottom-up information enable perception memory. Whereas top-down control has been attributed excitatory pathways, existence, connectivity, content inhibitory remain elusive. Here, we combine synaptic two-photon calcium imaging, circuit mapping, cortex-dependent learning, chemogenetics in mice identify GABAergic afferents from subthalamic zona incerta as major source input neocortex. Incertocortical transmission undergoes robust plasticity during learning that improves transfer mediates behavioral Unlike incertocortical form disinhibitory encodes learned relevance bidirectional manner rapid appearance negative responses serves main driver changes stimulus representation. Our results therefore reveal distinctive contribution long-range (dis)inhibitory computational flexibility neocortical circuits.

Language: Английский

Citations

28
Kinetic features dictate sensorimotor alignment in the superior colliculus DOI Creative Commons
Ana González-Rueda, Kristopher T. Jensen, Mohammadreza Noormandipour

et al.

Nature, Journal Year: 2024, Volume and Issue: 631(8020), P. 378 - 385

Published: July 3, 2024

Abstract The execution of goal-oriented behaviours requires a spatially coherent alignment between sensory and motor maps. current model for sensorimotor transformation in the superior colliculus relies on topographic mapping static spatial receptive fields onto movement endpoints 1–6 . Here, to experimentally assess validity this canonical alignment, we dissected visuo-motor network performed vivo intracellular extracellular recordings across layers, restrained unrestrained conditions, both visual tuning individual premotor neurons. We found that collicular units have poorly defined respond instead kinetic features, revealing existence direct vectorial space vectors, rather than as canonically hypothesized. show neural built according these principles is ideally placed sustain ethological such rapid interception moving targets. These findings reveal novel dimension process. By extending from domain work provides conceptual framework understanding nature convergence its relevance guiding goal-directed behaviours.

Language: Английский

Citations

11
Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines DOI Creative Commons
Chen Chen, Yuanming Liu, Jianhua Cang

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112194 - 112194

Published: March 11, 2025

Recent studies have revealed diverse neuron types in the superior colliculus (SC), a midbrain structure critical for sensorimotor transformation. Here, as an important step toward studying function of these subtypes, we characterize 10 transgenic mouse lines based on recently published molecular atlas superficial SC. We show that Cre or fluorescence expression some corresponds specifically to certain transcriptomic types. These include two GENSAT been used target morphological cell SC and three knockin lines. In contrast, such correspondence is not seen other tested mice. Importantly, pattern marker genes all highly consistent with atlas. Together, our support correlation between types, identify useful targeting genetically, demonstrate validity single-cell transcriptomics data.

Language: Английский

Citations

1