The evolution of SARS-CoV-2

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(6), P. 361 - 379

Published: April 5, 2023

Language: Английский

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A multinational Delphi consensus to end the COVID-19 public health threat

Nature, Journal Year: 2022, Volume and Issue: 611(7935), P. 332 - 345

Published: Nov. 3, 2022

Abstract Despite notable scientific and medical advances, broader political, socioeconomic behavioural factors continue to undercut the response COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel 386 academic, health, non-governmental organization, government other experts in from 112 countries territories recommend specific actions end persistent global threat public health. The developed set 41 consensus statements 57 recommendations governments, health systems, industry key stakeholders across six domains: communication; systems; vaccination; prevention; treatment care; inequities. In wake nearly three years fragmented national responses, it is instructive note that highest-ranked call for adoption whole-of-society whole-of-government approaches 1 , while maintaining proven prevention measures using vaccines-plus approach 2 employs range financial support complement vaccination. Other with at least 99% combined agreement advise governments improve communication, rebuild trust engage communities 3 management responses. findings which have been further endorsed by 184 organizations globally, include points unanimous agreement, well >5% disagreement, provide social policy address inadequacies help bring an end.

Language: Английский

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Wastewater surveillance of pathogens can inform public health responses

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 1992 - 1995

Published: Sept. 8, 2022

Language: Английский

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Wastewater surveillance for public health

Science, Journal Year: 2023, Volume and Issue: 379(6627), P. 26 - 27

Published: Jan. 5, 2023

Wastewater contains information on pathogen spread, evolution, and outbreak risk

Language: Английский

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Prevalence of persistent SARS-CoV-2 in a large community surveillance study

Nature, Journal Year: 2024, Volume and Issue: 626(8001), P. 1094 - 1101

Published: Feb. 21, 2024

Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future outbreaks

Language: Английский

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Toward a global virus genomic surveillance network

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(6), P. 861 - 873

Published: March 6, 2023

Language: Английский

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Wastewater sequencing reveals community and variant dynamics of the collective human virome

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 28, 2023

Wastewater is a discarded human by-product, but its analysis may help us understand the health of populations. Epidemiologists first analyzed wastewater to track outbreaks poliovirus decades ago, so-called wastewater-based epidemiology was reinvigorated monitor SARS-CoV-2 levels while bypassing difficulties and pit falls individual testing. Current approaches overlook activity most viruses preclude deeper understanding virome community dynamics. Here, we conduct comprehensive sequencing-based 363 longitudinal samples from ten distinct sites in two major cities. Critical detection use viral probe capture set targeting thousands species or variants. Over 450 pathogenic 28 families are observed, which have never been detected such samples. Sequencing reads established pathogens emerging correlate clinical data sets SARS-CoV-2, influenza virus, monkeypox viruses, outlining public utility this approach. Viral communities tightly organized by space time. Finally, abundant yield sequence variant information consistent with regional spread evolution. We reveal landscape potential improve our outbreaks, transmission, effects on overall population health.

Language: Английский

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Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond

Clinical Microbiology Reviews, Journal Year: 2023, Volume and Issue: 37(1)

Published: Dec. 14, 2023

SUMMARY Wastewater-based surveillance (WBS) has undergone dramatic advancement in the context of coronavirus disease 2019 (COVID-19) pandemic. The power and potential this platform technology were rapidly realized when it became evident that not only did WBS-measured SARS-CoV-2 RNA correlate strongly with COVID-19 clinical within monitored populations but also, fact, functioned as a leading indicator. Teams from across globe innovated novel approaches by which wastewater could be collected diverse sewersheds ranging treatment plants (enabling community-level surveillance) to more granular locations including individual neighborhoods high-risk buildings such long-term care facilities (LTCF). Efficient processes enabled extraction concentration highly dilute matrix. Molecular genomic tools identify, quantify, characterize its various variants adapted programs applied these mixed environmental systems. Novel data-sharing allowed information mobilized made immediately available public health government decision-makers even public, enabling evidence-informed decision-making based on local dynamics. WBS since been recognized tool transformative potential, providing near-real-time cost-effective, objective, comprehensive, inclusive data changing prevalence measured analytes space time populations. However, consequence rapid innovation hundreds teams simultaneously, tremendous heterogeneity currently exists literature. This manuscript provides state-of-the-art review established details current work underway expanding scope other infectious targets.

Language: Английский

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First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023

Eurosurveillance, Journal Year: 2023, Volume and Issue: 28(36)

Published: Sept. 7, 2023

We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate the is circulating country at a low level. This new with many spike gene mutations was classified as under monitoring by World Health Organization on 17 August 2023. Further global COVID-19, other SARS-CoV-2 variants highly warranted.

Language: Английский

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Wastewater-based prediction of COVID-19 cases using a highly sensitive SARS-CoV-2 RNA detection method combined with mathematical modeling

Environment International, Journal Year: 2023, Volume and Issue: 173, P. 107743 - 107743

Published: Jan. 7, 2023

Wastewater-based epidemiology (WBE) has the potential to predict COVID-19 cases; however, reliable methods for tracking SARS-CoV-2 RNA concentrations (C

Language: Английский

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