Disentangling how the brain is wired DOI Creative Commons
Simon G. Sprecher

Fly, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 31, 2024

Language: Английский

Neuronal wiring diagram of an adult brain DOI Creative Commons
Sven Dorkenwald, Arie Matsliah, Amy Sterling

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 124 - 138

Published: Oct. 2, 2024

Language: Английский

Citations

134
Whole-brain annotation and multi-connectome cell typing of Drosophila DOI Creative Commons
Philipp Schlegel, Yijie Yin, Alexander Shakeel Bates

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 139 - 152

Published: Oct. 2, 2024

Language: Английский

Citations

87
Connectome-driven neural inventory of a complete visual system DOI Creative Commons
Aljoscha Nern, Frank Loesche, Shin-ya Takemura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 18, 2024

Vision provides animals with detailed information about their surroundings, conveying diverse features such as color, form, and movement across the visual scene. Computing these parallel spatial requires a large network of neurons, that in distant flies humans, regions comprise half brain's volume. These brain often reveal remarkable structure-function relationships, neurons organized along maps shapes directly relate to roles processing. To unravel stunning diversity complex system, careful mapping neural architecture matched tools for targeted exploration circuitry is essential. Here, we report new connectome right optic lobe from male Drosophila central nervous system FIB-SEM volume comprehensive inventory fly's neurons. We developed computational framework quantify anatomy establishing basis interpreting how vision. By integrating this analysis connectivity information, neurotransmitter identity, expert curation, classified ~53,000 into 727 types, which are systematically described named first time. Finally, share an extensive collection split-GAL4 lines our neuron type catalog. Together, set data unlock possibilities systematic investigations vision Drosophila, foundation deeper understanding sensory

Language: Английский

Citations

28
Network statistics of the whole-brain connectome of Drosophila DOI Creative Commons
Albert Lin, Runzhe Yang, Sven Dorkenwald

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 153 - 165

Published: Oct. 2, 2024

Language: Английский

Citations

26
Connectome-driven neural inventory of a complete visual system DOI Creative Commons
Aljoscha Nern, Frank Loesche, Shin-ya Takemura

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form movement across the visual scene. Computing these parallel spatial requires a large network of neurons. Consequently, from flies to humans, regions in brain constitute half its volume. These often have marked structure–function relationships, neurons organized along maps shapes that directly relate roles processing. More than century anatomical studies catalogued detail cell types fly systems 1–3 , behavioural physiological experiments examined capabilities flies. To unravel diversity complex system, careful mapping neural architecture matched tools for targeted exploration this circuitry is essential. Here we present connectome right optic lobe male Drosophila melanogaster acquired using focused ion beam milling scanning electron microscopy. We established comprehensive inventory developed computational framework quantify anatomy. Together, data establish basis interpreting how vision. By integrating analysis connectivity information, neurotransmitter identity expert curation, classified approximately 53,000 into 732 types. are systematically described newly named. Finally, share an extensive collection split-GAL4 lines our neuron-type catalogue. Overall, set unlocks new possibilities systematic investigations vision foundation deeper understanding sensory

Language: Английский

Citations

2
The fly connectome reveals a path to the effectome DOI Creative Commons
Dean A. Pospisil, Max Jameson Aragon, Sven Dorkenwald

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 201 - 209

Published: Oct. 2, 2024

Language: Английский

Citations

10
Predicting visual function by interpreting a neuronal wiring diagram DOI Creative Commons
H. Sebastian Seung

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 113 - 123

Published: Oct. 2, 2024

Language: Английский

Citations

8
Temporal and Notch identity determine layer targeting and synapse location of medulla neurons DOI Creative Commons
Isabel Holguera, Yee‐Chun Chen, Yu‐Chieh Chen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

How specification mechanisms that generate neural diversity translate into specific neuronal targeting, connectivity, and function in the adult brain is not understood. In medulla region of Drosophila optic lobe, progenitors different neurons a fixed order by sequentially expressing series temporal transcription factors as they age. Then, Notch signaling intermediate further diversifies progeny. By establishing birth neurons, we found their identity correlates with depth neuropil targeting brain, for both local interneurons projection neurons. We show this identity-dependent unfolds early development genetically determined. leveraging Electron Microscopy reconstruction fly determined synapse location lobe neuropils find it significantly associated status. Moreover, all putative same predicted share similar location, indicating ensembles layers encode visual functions. conclusion, status can predict function, linking developmental patterning connectivity functional features brain.

Language: Английский

Citations

1
Network Statistics of the Whole-Brain Connectome ofDrosophila DOI Creative Commons
Albert Lin, Runzhe Yang, Sven Dorkenwald

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 29, 2023

Abstract Brains comprise complex networks of neurons and connections. Network analysis applied to the wiring diagrams brains can offer insights into how support computations regulate information flow. The completion first whole-brain connectome an adult Drosophila , largest date, containing 130,000 millions connections, offers unprecedented opportunity analyze its network properties topological features. To gain local connectivity, we computed prevalence two- three-node motifs, examined their strengths neurotransmitter compositions, compared these metrics with other animals. We discovered that fly brain displays rich club organization, a large population (30% percent connectome) highly connected neurons. identified subsets may serve as integrators or broadcasters signals. Finally, subnetworks based on 78 anatomically defined regions neuropils. These data products are shared within FlyWire Codex will foundation for models experiments exploring relationship between neural activity anatomical structure.

Language: Английский

Citations

19
Synaptic architecture of leg and wing premotor control networks inDrosophila DOI Creative Commons
Ellen Lesser, Anthony W. Azevedo, Jasper S. Phelps

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles. MN activity coordinated complex premotor networks that allow individual muscles contribute many different behaviors. Here, we use connectomics analyze wiring logic circuits controlling

Language: Английский

Citations

17