Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(4), P. 203 - 215
Published: Feb. 21, 2024
Language: Английский
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: Oct. 8, 2022
Abstract Chimeric antigen receptor T (CAR-T) cells therapy has revolutionized the treatment paradigms for hematological malignancies, with multi-line therapy-refractory patients achieving durable complete remissions (CR) and relatively high objective response rate (ORR). So far, many CAR-T products, such as Kymriah, Yescarta Tecartus, have been developed got unprecedented results. However, some may relapse afterwards, driving intense investigations into promoting development of novel strategies to overcome resistance mechanisms relapse. Notable technical progress, nanobodies CRISPR-Case9, also taken place ensure cell fully satisfies its medical potential. In this review, we outline basic principles manufacturing processes therapy, summarize similarities differences in efficacy different products well their corresponding clinical results, discuss immunotherapy combined other effects drug therapy.
Language: Английский
Citations
126
Science, Journal Year: 2022, Volume and Issue: 378(6622), P. 853 - 858
Published: Nov. 24, 2022
Immune cells are being engineered to recognize and respond disease states, acting as a "living drug" when transferred into patients. Therapies based on immune now clinical reality, with multiple T cell therapies approved for treatment of hematologic malignancies. Ongoing preclinical studies testing diverse strategies modify the fate function applications in cancer, infectious disease, beyond. Here, we discuss current progress treating human therapeutics, emerging engineering, challenges facing field, particular emphasis where most effort has been applied date.
Language: Английский
Citations
118
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(2), P. 107 - 124
Published: Jan. 30, 2023
Language: Английский
Citations
83
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
83
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: Aug. 18, 2023
Abstract Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to subsequent specific enhanced T receptor (TCR)-T and chimeric antigen (CAR)-T therapies, many novel strategies cancer treatment been developed. Owing its promising outcomes, CAR-T therapy has revolutionized field ACTs, particularly hematologic malignancies. Despite these advances, still limitations in both autologous allogeneic settings, including practicality toxicity issues. To overcome challenges, researchers focused on application CAR engineering technology other types immune engineering. Consequently, several new based developed, CAR-NK, CAR-macrophage, CAR-γδT, CAR-NKT. In this review, we describe development, advantages, possible challenges aforementioned ACTs discuss current aimed at maximizing therapeutic potential ACTs. We also provide an overview various gene transduction employed immunotherapy given their importance Furthermore, possibility that capable creating a positive feedback circuit, as healthy systems do, could address flaw single type ACT, thus serve key players future immunotherapy.
Language: Английский
Citations
82
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: July 24, 2023
Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.
Language: Английский
Citations
61
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 9(2), P. 100 - 118
Published: Dec. 22, 2023
Language: Английский
Citations
52
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 16, 2024
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.
Language: Английский
Citations
24
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 406 - 418
Published: April 12, 2024
T cells modified to express intelligently designed chimeric antigen receptors (CARs) are exceptionally powerful therapeutic agents for relapsed and refractory blood cancers have the potential revolutionize therapy many other diseases. To circumvent complexity cost associated with broad-scale implementation of ex vivo manufactured adoptive cell products, alternative strategies generate CAR in by direct infusion nanoparticle-formulated nucleic acids or engineered viral vectors under development received a great deal attention past few years. Here, we outline manufacturing process as motivating framework discuss emerging data from preclinical models highlight potency approach, applicability new disease indications, remaining challenges clinical readiness, including delivery specificity, long term efficacy, safety.
Language: Английский
Citations
22
National Science Review, Journal Year: 2024, Volume and Issue: 11(4)
Published: Jan. 11, 2024
ABSTRACT The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process T-cell proliferation lymph nodes. This scaffold gathers function loading, delivery, activation expansion CAR-T to enhance therapeutic effects on porous device made from poly(lactic-co-glycolic acid) microfluidic technique with modification stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well cytokines. fosters 50-fold cell vitro 15-fold vivo. Particularly, it maintains long-lasting up 30 days cervical tumor model significantly inhibits growth. biomimetic delivery strategy provides versatile platform treating
Language: Английский
Citations
19