Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123287 - 123287
Published: March 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
83
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)
Published: June 11, 2024
The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.
Language: Английский
Citations
56
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(16), P. 9075 - 9103
Published: Jan. 1, 2024
Towards the sustainable production of biomass-derived materials with smart functionality.
Language: Английский
Citations
24
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 20, 2025
Language: Английский
Citations
4
Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428
Published: Jan. 9, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Language: Английский
Citations
2
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 486 - 498
Published: May 14, 2024
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control the COVID-19 pandemic. However, mRNA have raised concerns about their potential toxicity and clinical safety, including side effects, such as myocarditis, anaphylaxis, pericarditis. In this study, we investigated trehalose glycolipids-containing LNP (LNP S050L) reduce risks associated ionizable lipids. Trehalose glycolipids can form hydrogen bonds polar biomolecules, allowing formation a stable structure by replacing half efficacy safety S050L were evaluated encapsulating encoding luciferase reporter gene measuring expression organ toxicity, respectively. Furthermore, mice immunized an S050L-formulated vaccine expressing influenza hemagglutinin exhibited significant reduction in heart, spleen, liver, while sustaining immune efficiency, compared conventional LNPs (Con-LNPs). Our findings suggest that S050L, glycolipid-based LNP, could facilitate safe improved safety.
Language: Английский
Citations
14
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)
Published: Oct. 1, 2024
ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.
Language: Английский
Citations
11
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(28), P. 19218 - 19228
Published: July 2, 2024
The messenger RNA (mRNA) vaccines hold great significance in contagion prevention and cancer immunotherapy. However, safely effectively harnessing innate immunity to stimulate robust durable adaptive immune protection is crucial, yet challenging. In this study, we synthesized a library of stimuli-responsive bivalent ionizable lipids (srBiv iLPs) with smart molecular blocks responsive esterase, H
Language: Английский
Citations
9
Discover Polymers., Journal Year: 2025, Volume and Issue: 2(1)
Published: Feb. 12, 2025
Language: Английский
Citations
1