In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells DOI Creative Commons
Xi Zhu, Yuanzhen Suo, Yuting Fu

et al.

Light Science & Applications, Journal Year: 2021, Volume and Issue: 10(1)

Published: May 28, 2021

Abstract Circulating tumor cells (CTCs) is an established biomarker of cancer metastasis. The circulation dynamics CTCs are important for understanding the mechanisms underlying cell dissemination. Although studies have revealed that circadian rhythm may disrupt growth tumors, it generally unclear whether controls release CTCs. In clinical examinations, current in vitro methods detecting blood samples based on a fundamental assumption CTC counts peripheral do not change significantly over time, which being challenged by recent studies. Since practical to draw from patients repeatedly, feasible strategy investigate monitor them vivo detection methods. Fluorescence flow cytometry (IVFC) powerful optical technique able detect fluorescent circulating directly living animals noninvasive manner long period time. this study, we applied fluorescence IVFC noninvasively orthotopic mouse model human prostate cancer. We observed exhibited stochastic bursts progression. probability bursting activity was higher at early stages than late stages. longitudinally monitored 24-h period, and our results striking daily oscillations peaked onset night (active phase rodents), suggesting might be regulated rhythm.

Language: Английский

The Role of Daylight for Humans: Gaps in Current Knowledge DOI Creative Commons
Mirjam Münch, Anna Wirz‐Justice, Steven A. Brown

et al.

Clocks & Sleep, Journal Year: 2020, Volume and Issue: 2(1), P. 61 - 85

Published: Feb. 28, 2020

Daylight stems solely from direct, scattered and reflected sunlight, undergoes dynamic changes in irradiance spectral power composition due to latitude, time of day, year the nature physical environment (reflections, buildings vegetation). Humans their ancestors evolved under these natural day/night cycles over millions years. Electric light, a relatively recent invention, interacts competes with light–dark cycle impact human biology. What are consequences living industrialised urban areas much less daylight more use electric throughout day (and at night), on general health quality life? In this workshop report, we have classified key gaps knowledge research into three main groups: (I) uncertainty as quantity needed for “optimal” physiological psychological functioning, (II) lack consensus practical measurement assessment methods tools monitoring real (day) light exposure across multiple scales, (III) insufficient integration exchange bases different disciplines. Crucial short long-term objectives fill proposed.

Language: Английский

Citations

132
Cancer and stress: NextGen strategies DOI Creative Commons
Bai Cui, Fei Peng, Jinxin Lü

et al.

Brain Behavior and Immunity, Journal Year: 2020, Volume and Issue: 93, P. 368 - 383

Published: Nov. 5, 2020

Chronic stress is well-known to cause physiological distress that leads body balance perturbations by altering signaling pathways in the neuroendocrine and sympathetic nervous systems. This increases allostatic load, which cost of fluctuations are required cope with psychological challenges as well changes physical environment. Recent studies have enriched our knowledge about role chronic disease development, especially carcinogenesis. Stress stimulates hypothalamic-pituitaryadrenal (HPA) axis system (SNS), resulting an abnormal release hormones. These activate elevate expression downstream oncogenes. occurs activation specific receptors promote numerous cancer biological processes, including proliferation, genomic instability, angiogenesis, metastasis, immune evasion metabolic disorders. Moreover, accumulating evidence has revealed β-adrenergic receptor (ADRB) antagonists target inhibitors exhibit remarkable anti-tumor effects. Psychosomatic behavioral interventions (PBI) traditional Chinese medicine (TCM) also effectively relieve impact patients. In this review, we discuss recent advances underlying mechanisms responsible for promoting malignancies. Collectively, these data provide approaches NextGen pharmacological therapies, PBI TCM reduce burden tumorigenesis.

Language: Английский

Citations

90
Circadian Rhythms, Disease and Chronotherapy DOI
Yool Lee, Jeffrey Field, Amita Sehgal

et al.

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 36(6), P. 503 - 531

Published: Sept. 22, 2021

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating

Language: Английский

Citations

90
Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism DOI
Amandine Verlande, Selma Masri

Trends in Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 30(7), P. 445 - 458

Published: May 30, 2019

Language: Английский

Citations

87
Coupled network of the circadian clocks: a driving force of rhythmic physiology DOI Creative Commons
Anna‐Marie Finger, Charna Dibner, Achim Kramer

et al.

FEBS Letters, Journal Year: 2020, Volume and Issue: 594(17), P. 2734 - 2769

Published: Aug. 4, 2020

The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt daily changes in their environment. In mammals, clocks form a hierarchically organized network with ‘master clock’ located the suprachiasmatic nucleus hypothalamus, which ensures entrainment subsidiary environmental cycles. Robust rhythmicity body indispensable for temporally coordinating organ functions, disruption or misalignment rhythms caused instance by modern lifestyle strongly associated various widespread diseases. This review aims provide comprehensive overview our current knowledge about molecular architecture system‐level organization mammalian oscillators. Furthermore, we discuss regulatory roles peripheral cell physiology implication temporal coordination metabolism human health disease. Finally, summarize methods assessing humans.

Language: Английский

Citations

87
Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms DOI
Wenjing Xuan, Maciej S. Lesniak, C. David James

et al.

Trends in Immunology, Journal Year: 2021, Volume and Issue: 42(4), P. 280 - 292

Published: March 1, 2021

Language: Английский

Citations

87
Metabolic rivalry: circadian homeostasis and tumorigenesis DOI
Kenichiro Kinouchi, Paolo Sassone–Corsi

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(11), P. 645 - 661

Published: Sept. 7, 2020

Language: Английский

Citations

86
Origins of human disease: the chrono-epigenetic perspective DOI
Edward Oh, Artūras Petronis

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(8), P. 533 - 546

Published: April 26, 2021

Language: Английский

Citations

84
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies DOI Open Access
Keisaku Sato, Fanyin Meng, Heather Francis

et al.

Journal of Pineal Research, Journal Year: 2020, Volume and Issue: 68(3)

Published: Feb. 15, 2020

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in hypothalamus, melatonin is produced pineal gland. Although brain detects light through retinas regulates secretion throughout body, liver has independent circadian as well production. Previous studies indicate association between with various diseases, disruption of or expression may promote steatosis, inflammation, cancer development. It known that strong antioxidant effects. Alcohol drinking excess fatty acid accumulation produces reactive oxygen species oxidative stress leading to injuries. Melatonin administration protects these stress-induced damage improves conditions. Recent have demonstrated not limited effects it other contributing management Accumulating evidence suggests restoring supplementation be promising therapeutic strategies for diseases. This review summarizes recent findings functional roles potentials

Language: Английский

Citations

83
Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs DOI Creative Commons
Alexandre Vallée, Yves Lecarpentier,

Jean-Noël Vallée

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(7), P. 726 - 726

Published: July 15, 2019

Chronic inflammation and oxidative stress are common co-substantial pathological processes accompanying contributing to cancers. Numerous epidemiological studies have indicated that non-steroidal anti-inflammatory drugs (NSAIDs) could a positive effect on both the prevention of cancer tumor therapy. hypotheses postulated NSAIDs slow growth by acting chronic stress. This review takes closer look at these hypotheses. In process, one major signaling pathways involved is WNT/β-catenin pathway, which appears be upregulated. pathway closely associated with in The administration has been observed help downregulation thus control growth. act as PPARγ agonists. opposing manners. agonists can promote cell cycle arrest, differentiation, apoptosis, reduce inflammation, stress, proliferation, invasion, migration. parallel, dysregulation circadian rhythms (CRs) contributes development through upregulation canonical pathway. By stimulating expression, CRs regulation many key genes. treatment would appear an interesting therapeutic strategy, acts their role regulating activity levels.

Language: Английский

Citations

82