State-dependent effects of neural stimulation on brain function and cognition

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(8), P. 459 - 475

Published: May 16, 2022

Language: Английский

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Cingulate dynamics track depression recovery with deep brain stimulation

Nature, Journal Year: 2023, Volume and Issue: 622(7981), P. 130 - 138

Published: Sept. 20, 2023

Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error adjustments due to individual trajectories and subjective reporting 3 We currently lack objective brain-based biomarkers guide clinical decisions by distinguishing natural transient mood fluctuations from situations intervention. To address this gap, we used a new device enabling electrophysiology recording deliver SCC DBS ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At study endpoint 24 weeks, 90% demonstrated robust response, 70% achieved remission. Using local field potentials available six participants, deployed an explainable artificial intelligence approach identify potential changes indicating patient’s current state. This biomarker distinct effects, sensitive therapeutic accurate at capturing states. Variable are predicted degree preoperative damage structural integrity functional connectivity within targeted white matter treatment network, matched facial expression detected using data-driven video analysis. Our results demonstrate utility in management personalized insight into relationship between multifaceted (functional, anatomical behavioural) features pathology, motivating further research causes variability treatment.

Language: Английский

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Mobile cognition: imaging the human brain in the ‘real world’

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(6), P. 347 - 362

Published: April 12, 2023

Language: Английский

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Non-invasive temporal interference electrical stimulation of the human hippocampus

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(11), P. 1994 - 2004

Published: Oct. 19, 2023

Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use deployment in research. Temporal interference (TI) a strategy for non-invasive steerable DBS using multiple kHz-range electric fields difference frequency within the range of neural activity. Here we report validation concept humans. We field modeling measurements human cadaver verify that locus transcranial TI can be steerably focused hippocampus minimal exposure overlying cortex. then functional magnetic resonance imaging behavioral experiments show focally modulate hippocampal activity enhance accuracy episodic memories healthy Our results demonstrate targeted, electrical deep structures brain.

Language: Английский

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Deep Brain Stimulation for Depression

Neurotherapeutics, Journal Year: 2022, Volume and Issue: 19(4), P. 1229 - 1245

Published: July 1, 2022

Language: Английский

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New and emerging approaches to treat psychiatric disorders

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(2), P. 317 - 333

Published: Feb. 1, 2023

Language: Английский

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Integrative Brain Network and Salience Models of Psychopathology and Cognitive Dysfunction in Schizophrenia

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 94(2), P. 108 - 120

Published: Oct. 4, 2022

Language: Английский

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Artificial intelligence in psychiatry research, diagnosis, and therapy

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 87, P. 103705 - 103705

Published: July 22, 2023

Language: Английский

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Functional connectomics in depression: insights into therapies

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(9), P. 814 - 832

Published: June 5, 2023

Language: Английский

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Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(8)

Published: Jan. 10, 2023

Abstract Advances in implantable bioelectronics for the nervous system are reinventing stimulation, inhibition, and sensing of neuronal activity. These efforts promise not just breakthrough treatments several neurological psychiatric conditions but also signal beginning a new era computer‐controlled human therapeutics. Batteries remain major power source all implanted electrical neuromodulation devices, which impairs miniaturization necessitates replacement surgery when battery is drained. Triboelectric nanogenerators (TENGs) have recently emerged as an innovative solution self‐powered, closed loop neurostimulation devices. TENGs can leverage biomechanical activities different body organs to sustainably generate electricity neurostimulation. This review features advances they pave way self‐sustainable A comprehensive TENG research brain, autonomic, somatic systems provided. The direction growth this field, publication trends, modes discussed. Finally, insightful outlook into challenges facing neuromodulators reach clinical practice provided, solutions maladies proposed.

Language: Английский

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