Diet-Derived Antioxidants: The Special Case of Ergothioneine DOI Creative Commons
Barry Halliwell, Richard M.Y. Tang, Irwin K. Cheah

et al.

Annual Review of Food Science and Technology, Journal Year: 2023, Volume and Issue: 14(1), P. 323 - 345

Published: Jan. 10, 2023

This article reviews what is presently known about the biological roles of diet-derived compound ergothioneine (ET). ET seems important to humans because it rapidly taken up from diet by a transporter largely or completely specific for ET, and once retained within body weeks months. The various possible functions in vivo are explored. Much emphasis has been placed on antioxidant properties but although these well established vitro, evidence that activity principal function weak. not unique this: vitamin C polyphenols such as flavonoids also By contrast, α-tocopherol demonstrated effects humans.

Language: Английский

Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism DOI

Shanshan Qiao,

Chang Liu, Li Sun

et al.

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(10), P. 1271 - 1286

Published: Oct. 17, 2022

Language: Английский

Citations

104
The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice DOI Creative Commons
Yong Fan, René Klinkby Støving,

Samar Berreira Ibraim

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(5), P. 787 - 802

Published: April 17, 2023

Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are women and it has population prevalence about 1%, but evidence-based treatment lacking. The pathogenesis AN probably involves genetics various environmental factors, altered gut microbiota been observed in individuals using amplicon sequencing relatively small cohorts. Here we investigated whether disrupted contributes to pathogenesis. Shotgun metagenomics metabolomics were performed on faecal serum samples, respectively, from cohort 77 females 70 healthy females. Multiple bacterial taxa (for example, Clostridium species) correlated estimates behaviour mental health. virome was also including reduction viral-bacterial interactions. Bacterial functional modules associated the degradation neurotransmitters enriched structural variants bacteria linked metabolic features AN. Serum revealed increase metabolites reduced food intake indole-3-propionic acid). Causal inference analyses implied that potentially mediating impact behaviour. Further, transplantation germ-free mice under energy-restricted feeding mirror We found weight gain induced hypothalamic adipose tissue gene expression related aberrant energy metabolism Our 'omics' mechanistic studies imply disruptive microbiome may contribute

Language: Английский

Citations

82
Risk assessment with gut microbiome and metabolite markers in NAFLD development DOI
Howell Leung, Xiaoxue Long, Yueqiong Ni

et al.

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(648)

Published: June 8, 2022

A growing body of evidence suggests interplay between the gut microbiota and pathogenesis nonalcoholic fatty liver disease (NAFLD). However, role microbiome in early detection NAFLD is unclear. Prospective studies are necessary for identifying reliable, markers NAFLD. We evaluated 2487 individuals a community-based cohort who were followed up 4.6 years after initial clinical examination biospecimen sampling. Metagenomic metabolomic characterizations using stool serum samples taken at baseline performed 90 participants progressed to controls remained free follow-up visit. Cases matched gender, age, mass index (BMI) follow-up, 4-year BMI change. Machine learning models integrating microbial signatures (14 features) correctly classified (auROCs 0.72 0.80) based on their status fat accumulation follow up, outperforming other prognostic 0.58 0.60). confirmed biological relevance features by testing diagnostic ability four external case-control cohorts examined biopsy or magnetic resonance spectroscopy, from Asia, Europe, United States. Our findings raise possibility warning development.

Language: Английский

Citations

81
Gut microbiota–bile acid–skeletal muscle axis DOI Creative Commons
Laura Mancin,

Gary D. Wu,

Antonio Paoli

et al.

Trends in Microbiology, Journal Year: 2022, Volume and Issue: 31(3), P. 254 - 269

Published: Oct. 30, 2022

The gut microbiota represents a 'metabolic organ' that can regulate human metabolism. Intact contributes to host homeostasis, whereas compositional perturbations, termed dysbiosis, are associated with wide range of diseases. Recent evidence demonstrates and the accompanying loss microbiota-derived metabolites, results in substantial alteration skeletal muscle As an example, bile acids, produced liver further metabolized by intestinal microbiota, considerable interest since they several metabolic pathways activating nuclear receptors, including farnesoid X receptor (FXR). Indeed, may lead atrophy via acid-FXR pathway. This Review aims suggest new pathway connects different mechanisms, involving gut-muscle axis, often seen as unrelated, and, starting from preclinical studies, we hypothesize strategies aimed at optimizing functionality.

Language: Английский

Citations

81
Benchmarking second and third-generation sequencing platforms for microbial metagenomics DOI Creative Commons
Victoria Meslier, Benoît Quinquis, Kévin Da Silva

et al.

Scientific Data, Journal Year: 2022, Volume and Issue: 9(1)

Published: Nov. 11, 2022

Abstract Shotgun metagenomic sequencing is a common approach for studying the taxonomic diversity and metabolic potential of complex microbial communities. Current methods primarily use second generation short read sequencing, yet advances in third long technologies provide opportunities to overcome some limitations sequencing. Here, we compared seven platforms, encompassing sequencers (Illumina HiSeq 300, MGI DNBSEQ-G400 DNBSEQ-T7, ThermoFisher Ion GeneStudio S5 Proton P1) (Oxford Nanopore Technologies MinION R9 Pacific Biosciences Sequel II). We constructed three uneven synthetic communities composed up 87 genomic strains DNAs per mock, spanning 29 bacterial archaeal phyla, representing most diverse used technology comparisons. Our results demonstrate that have advantages over platforms analyzing communities, but require careful library preparation optimal quantitative analysis. data also provides valuable resource testing benchmarking bioinformatics software metagenomics.

Language: Английский

Citations

75
Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health DOI Open Access
Cassandre Bedu-Ferrari, Paul Biscarrat, Philippe Langella

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2096 - 2096

Published: May 17, 2022

The colon harbours a dynamic and complex community of microorganisms, collectively known as the gut microbiota, which constitutes densest microbial ecosystem in human body. These commensal microbes play key role health diseases, revealing strong potential fine-tuning microbiota to confer benefits. In this context, dietary strategies targeting modulate composition metabolic function communities are increasing interest. One such strategy is use prebiotics, defined substrates that selectively utilised by host microorganisms benefit. A better understanding pathways involved breakdown prebiotics essential improve these nutritional strategies. review, we will present concept focus on main sources nature components, mainly non-digestible polysaccharides. We review mechanisms carbohydrates intestinal short-chain fatty acids (SCFAs) molecules mediating dialogue between host. Finally, studies exploring personalised responses prebiotic ingestion. conclusion, hope be interest identify mechanistic factors for optimization prebiotic-based

Language: Английский

Citations

71
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria DOI
Chenhao Li, Martin Stražar, Ahmed M. Mohamed

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(8), P. 1834 - 1852.e19

Published: April 1, 2024

Language: Английский

Citations

69
Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients DOI Creative Commons
Ruoyun Xiong, Courtney Gunter, Elizabeth Fleming

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(2), P. 273 - 287.e5

Published: Feb. 1, 2023

Language: Английский

Citations

61
Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort DOI Creative Commons
Sergi Sayols-Baixeras, Koen F. Dekkers, Gabriel Baldanzi

et al.

Circulation, Journal Year: 2023, Volume and Issue: 148(6), P. 459 - 472

Published: July 12, 2023

BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography–based measures of explore relevant clinical correlates. METHODS: We conducted a cross-sectional 8973 participants (50 65 years age) without overt disease from population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary was measured using artery calcium score tomography angiography. species abundance functional potential were assessed shotgun metagenomics sequencing fecal samples, evaluated multivariable regression models adjusted for cardiovascular risk factors. Associated association inflammatory markers, metabolites, corresponding saliva. RESULTS: The mean age sample 57.4 years, 53.7% female. calcification detected 40.3%, 5.4% had at least 1 stenosis >50% occlusion. Sixty-four associated independent factors, strongest observed Streptococcus anginosus oralis subsp ( P <1×10 –5 ). Associations largely similar across angiography–based measurements. Out 64 species, 19 including streptococci other commonly found oral cavity, high-sensitivity C-reactive protein plasma concentrations, 16 neutrophil counts. microbial that are cavity negatively indole propionate positively secondary bile acids imidazole propionate. Five 3 streptococci, correlated same saliva worse dental health Malmö Offspring Dental Study. Microbial dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, amino degradation score. CONCLUSIONS: provides evidence an composition characterized by increased spp systemic inflammation markers. Further longitudinal experimental studies warranted implications bacterial component atherogenesis.

Language: Английский

Citations

57
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective DOI
Mireia Valles‐Colomer, Cristina Menni, Sarah Berry

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 551 - 561

Published: March 1, 2023

Language: Английский

Citations

55