Graphene-Oxide Peptide-Containing Materials for Biomedical Applications DOI Open Access

Andreea Gostaviceanu,

Simona Gavrilaș, Lucian Copolovici

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10174 - 10174

Published: Sept. 22, 2024

This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides proteins. GO, a versatile nanomaterial oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity environmental impact. Peptides proteins can be functionalized GO surfaces through various methods, including non-covalent such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, van der Waals well covalent bonding reactions involving amide bond formation, esterification, thiol chemistry, click chemistry. These approaches enhance GO’s functionality several key areas: biosensing sensitive biomarker detection, theranostic imaging that integrates diagnostics therapy real-time treatment monitoring, targeted cancer where deliver drugs directly tumor sites while being tracked by techniques like MRI photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering aiding tissues’ bone, muscle, nerve regeneration, their antimicrobial properties improving infection-resistant medical devices. Despite potential, addressing stability scalability is essential fully harness benefits GBMs healthcare.

Language: Английский

Recent advances in targeted antibacterial therapy basing on nanomaterials DOI Creative Commons
Zhongmin Geng, Zhenping Cao, Jinyao Liu

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

Bacterial infection has become one of the leading causes death worldwide, particularly in low-income countries. Despite fact that antibiotics have provided successful management bacterial infections, long-term overconsumption and abuse contributed to emergence multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or serve as drug carriers been substantially developed an alternative fight against infection. Systematically deeply understanding mechanisms is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion either a passive active manner most promising approaches treatment by increasing local concentration around cells enhance inhibitory activity reduce side effects. Passive targeting approach widely explored searching nanomaterial-based alternatives antibiotics, while strategy relies on biomimetic biomolecular surface feature can selectively recognize In review article, we summarize recent developments field therapy based nanomaterials, which will promote more innovative thinking focusing multidrug-resistant

Language: Английский

Citations

179
Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes DOI Open Access
Josef Jampílek, Katarína Kráĺová

Materials, Journal Year: 2021, Volume and Issue: 14(5), P. 1059 - 1059

Published: Feb. 24, 2021

Carbon is one of the most abundant elements on Earth. In addition to well-known crystallographic modifications such as graphite and diamond, other allotropic carbon graphene-based nanomaterials nanotubes have recently come fore. These can be designed help deliver or target drugs more efficiently innovate therapeutic approaches, especially for cancer treatment, but also development new diagnostic agents malignancies are expected combine molecular imaging diagnosis with therapies. This paper summarizes latest drug delivery nanosystems based graphene, graphene quantum dots, oxide, reduced oxide nanotubes, mainly anticancer therapy.

Language: Английский

Citations

124
Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy DOI Open Access
Banendu Sunder Dash, Gils Jose, Yu‐Jen Lu

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(6), P. 2989 - 2989

Published: March 15, 2021

Cancer is one of the deadliest diseases in human history with extremely poor prognosis. Although many traditional therapeutic modalities-such as surgery, chemotherapy, and radiation therapy-have proved to be successful inhibiting growth tumor cells, their side effects may vastly limited actual benefits patient acceptance. In this context, a nanomedicine approach for cancer therapy using functionalized nanomaterial has been gaining ground recently. Considering ability carry various anticancer drugs act photothermal agent, use carbon-based nanomaterials advanced rapidly. Within those nanomaterials, reduced graphene oxide (rGO), family 2D carbon nanomaterial, emerged good candidate due its excellent conversion near infrared range, large specific surface area drug loading, well functional groups functionalization molecules such photosensitizers, siRNA, ligands, etc. By unique design, multifunctional nanosystems could designed based on rGO, which are endowed promising temperature/pH-dependent drug/gene delivery abilities multimodal therapy. This further augmented by additional advantages offered high biocompatibility, targeted delivery, enhanced effects. Herewith, we first provide an overview most effective reducing agents rGO synthesis via chemical reduction. was followed in-depth review application different treatment modalities and/or photodynamic therapy, gene chemotherapy/phototherapy, photothermal/immunotherapy.

Language: Английский

Citations

114
Antimicrobial peptide-based materials: opportunities and challenges DOI
Akhilesh Rai, Rafaela Ferrão, Paulo Palma

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(14), P. 2384 - 2429

Published: Jan. 1, 2022

The design of antimicrobial peptide-based materials for biomedical applications such as fighting infections in various organs, cancer therapy, gene delivery and detection bacteria.

Language: Английский

Citations

96
Enhanced Antibacterial and Anti-Biofilm Activities of Antimicrobial Peptides Modified Silver Nanoparticles DOI Creative Commons

Juanjuan Xu,

Yuanpei Li,

Haojie Wang

et al.

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 4831 - 4846

Published: July 1, 2021

The biofilms could protect bacteria from antibiotics and promote the production of drug-resistant strains, making more difficult to be eradicated. Thus, we developed an AMP@PDA@AgNPs nanocomposite, which is formed by modifying silver nanoparticles (AgNPs) with antimicrobial peptides (AMP) modified nanocomposite destroy biofilm in this study.The was prepared polymerization method characterized using ultraviolet-visible (UV-vis) spectroscopy, dynamic light scattering (DLS), Fourier transform-infrared spectroscopy (FT-IR), transmission electron microscope (TEM). antibacterial effects were investigated agar diffusion minimum inhibitory concentration (MIC) test. quantitative analysis formation conducted crystal violet staining confocal laser scanning (CLSM).The DLS TEM showed it a spherical 200 nm size well dispersed . results UV-vis FT-IR confirmed presence AMP AgNPs. had excellent biocompatibility at 100 μg/mL. And superior activity against both Gram-negative (E. coli, P. aeruginosa) Gram-positive (S. aureus) than AgNPs or AMP. Importantly, mRNA expression biofilm-related genes decreased under action nanocomposites.An good successfully prepared. destruct bacterial inhibiting genes. synergistic strategy AMPs provide new perspective for treatment infection.

Language: Английский

Citations

65
Synergistic photothermal antibacterial therapy enabled by multifunctional nanomaterials: progress and perspectives DOI
Xiaotian Bai, Yue Yang, Wen Zheng

et al.

Materials Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 7(3), P. 355 - 380

Published: Dec. 16, 2022

This review summarizes the applications of multifunctional nanomaterials for synergistic photothermal antibacterial therapy and discusses mechanism two treatment methods in therapy.

Language: Английский

Citations

63
Novel rGO@Fe3O4 nanostructures: An active electrocatalyst for hydrogen evolution reaction in alkaline media DOI
Abdul Hanan, Mukhtiar Ahmed, Muhammad Nazim Lakhan

et al.

Journal of the Indian Chemical Society, Journal Year: 2022, Volume and Issue: 99(5), P. 100442 - 100442

Published: March 23, 2022

Language: Английский

Citations

53
Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ’s thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities DOI Creative Commons
Alaa El Din Mahmoud,

Nourhan El-Maghrabi,

Mohamed Hosny

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(59), P. 89772 - 89787

Published: July 20, 2022

Abstract In the current work, various concentrations of aqueous extract Ziziphus spina-christi were employed for phytoreduction graphene oxide (GO). The green synthesized reduced (rGO) was characterized through UV-Vis spectrometry, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy, and energy-dispersive X-ray (SEM-EDX). Gas chromatography-mass spectrometry (GC-MS) denoted presence numerous phytoconstituents including ketones, terpenoids, fatty acids, esters, flavonoids, which acted as reducing capping agents. obtained results indicated increase in rGO yield shape with increasing concentration. optimized instantaneously ~100% removed methylene blue (MB) from water at 5 mg L −1 . However, removal efficiency slightly declined to reach 73.55 65.1% 10 15 , respectively. A powerful antibacterial activity particularly against gram-negative bacteria a high concentration 2 × 8 CFU mL confirmed. Furthermore, demonstrated promising comparable antioxidant vitamin C DPPH free radical scavenging. While recorded 13.45 48.4%, attained 13.30 45.20% 12 50 μg

Language: Английский

Citations

51
Role of green chemistry in synthesis and modification of graphene oxide and its application: A review study DOI Creative Commons
Jaspreet Singh, Neha Jindal, Vineet Kumar

et al.

Chemical Physics Impact, Journal Year: 2023, Volume and Issue: 6, P. 100185 - 100185

Published: March 1, 2023

Language: Английский

Citations

30
Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications DOI Creative Commons

Suchita Paul,

Sandeep Verma, Yu‐Chie Chen

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(4), P. 1034 - 1055

Published: March 1, 2024

Pathogenic bacteria cause the deaths of millions people every year. With development antibiotics, hundreds and thousands people's lives have been saved. Nevertheless, can develop resistance to rendering them insensitive antibiotics over time. Peptides containing specific amino acids be used as antibacterial agents; however, they easily degraded by proteases in vivo. To address these issues, branched peptide dendrimers are now being considered good agents due their high efficacy, protease degradation, low cytotoxicity. The ease with which synthesized modified makes accessible for use various biological nonbiological fields. That is, hold a promising future prolonged efficacy without bacterial development. Their vivo stability multivalence allow effectively target multi-drug-resistant strains prevent biofilm formation. Thus, it is interesting an overview applications research, including possibility employing machine learning approaches design AMPs dendrimers. This review summarizes synthesis agents. challenges perspectives using also discussed.

Language: Английский

Citations

12