Pharmaceuticals,
Journal Year:
2021,
Volume and Issue:
14(6), P. 509 - 509
Published: May 26, 2021
In
this
study,
a
platinum(II)
complex
([Pt(H2L)(PPh3)]
complex)
containing
thiocarbohydrazone
as
the
ligand
was
tested
an
anti-proliferative
agent
against
ovarian
adenocarcinoma
(Caov-3)
and
human
colorectal
(HT-29)
through
MTT
assays.
Apoptotic
markers
were
by
AO/PI
double
staining
assay
DNA
fragmentation
test.
Flow
cytometry
conducted
to
measure
cell
cycle
distribution,
while
p53
caspase-8
pathways
via
immunofluorescence
assay.
Results
demonstrated
that
cytotoxic
effect
of
Pt(II)-thiocarbohydrazone
complexes
Caov-3
HT-29
cells
highly
significant,
triggered
activation
pathways.
Besides,
apoptosis
stimulated
associated
with
arrest
at
G0/G1
phase.
These
findings
suggest
target
inhibited
proliferation
cells,
resulting
in
induction
stimulation
The
present
data
suggests
could
also
be
promising
chemotherapeutic
for
other
types
cancer
cells.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 7891 - 7941
Published: Dec. 1, 2021
Abstract:
Despite
recent
advances
in
the
diagnosis
and
treatment
of
breast
cancer
(BC),
it
remains
a
global
health
issue
affecting
millions
women
annually.
Poor
prognosis
BC
patients
is
often
linked
to
drug
resistance
as
well
lack
effective
therapeutic
options
for
metastatic
triple-negative
BC.
In
response
these
unmet
needs,
extensive
research
efforts
have
been
devoted
exploring
anti-BC
potentials
natural
products
owing
their
multi-target
mechanisms
action
good
safety
profiles.
Various
medicinal
plant
extracts/essential
oils
bioactive
compounds
demonstrated
anti-cancer
activities
preclinical
models.
promising
results,
however,
clinical
translation
has
hindered
by
poor
stability,
aqueous
solubility
bioavailability.
There
attempts
overcome
limitations,
particularly
via
use
nano-based
delivery
systems
(NDDSs).
This
review
highlights
tumour
targeting
NDDSs,
advantages
disadvantages
major
classes
NDDSs
current
status
treatment.
Besides,
also
discusses
proposed
nanoformulations
nine
plants'
compounds;
selected
screening
various
scientific
databases,
including
PubMed,
Scopus
Google
Scholar,
based
on
following
keywords:
"Natural
Product
AND
Nanoparticle
Breast
Cancer".
Overall,
exhibit
improved
efficacy
against
models,
with
some
demonstrating
biocompatibility
normal
cell
lines
mouse
Further
studies
are,
warranted
ascertain
humans.
Keywords:
cancer,
delivery,
molecular
mechanisms,
nanoparticles,
products,
phytomedicine
Molecules,
Journal Year:
2022,
Volume and Issue:
27(20), P. 7059 - 7059
Published: Oct. 19, 2022
To
date,
there
are
no
antimicrobial
agents
available
in
the
market
that
have
absolute
control
over
growing
threat
of
bacterial
strains.
The
increase
production
capacity
antibiotics
and
antibacterial
resistance
bacteria
majorly
affected
a
variety
businesses
public
health.
Bimetallic
nanoparticles
(NPs)
with
two
separate
metals
been
found
to
stronger
potential
than
their
monometallic
versions.
This
enhanced
efficiency
bimetallic
is
due
synergistic
effect
participating
counterparts.
distinguish
between
mammals,
existence
diverse
metal
transport
systems
metalloproteins
necessary
for
use
Au–Ag
NPs,
just
like
any
other
NPs.
Due
very
low
toxicity
toward
human
cells,
these
particularly
gold–silver
might
prove
be
an
effective
weapon
arsenal
beat
emerging
drug-resistant
bacteria.
cellular
mechanism
activity
consists
cell
membrane
degradation,
disturbance
homeostasis,
oxidative
stress,
reactive
oxygen
species.
synthesis
can
performed
by
bottom-up
top-down
strategy.
technique
generally
includes
sol-gel,
chemical
vapor
deposition,
green
synthesis,
co-precipitation
methods,
whereas
laser
ablation
method.
review
highlights
key
prospects
mechanism,
process,
capabilities
against
wide
range
Additionally,
we
also
discussed
role
NPs
treatment
multidrug-resistant
infection
wound
healing.
Pharmaceuticals,
Journal Year:
2021,
Volume and Issue:
14(6), P. 509 - 509
Published: May 26, 2021
In
this
study,
a
platinum(II)
complex
([Pt(H2L)(PPh3)]
complex)
containing
thiocarbohydrazone
as
the
ligand
was
tested
an
anti-proliferative
agent
against
ovarian
adenocarcinoma
(Caov-3)
and
human
colorectal
(HT-29)
through
MTT
assays.
Apoptotic
markers
were
by
AO/PI
double
staining
assay
DNA
fragmentation
test.
Flow
cytometry
conducted
to
measure
cell
cycle
distribution,
while
p53
caspase-8
pathways
via
immunofluorescence
assay.
Results
demonstrated
that
cytotoxic
effect
of
Pt(II)-thiocarbohydrazone
complexes
Caov-3
HT-29
cells
highly
significant,
triggered
activation
pathways.
Besides,
apoptosis
stimulated
associated
with
arrest
at
G0/G1
phase.
These
findings
suggest
target
inhibited
proliferation
cells,
resulting
in
induction
stimulation
The
present
data
suggests
could
also
be
promising
chemotherapeutic
for
other
types
cancer
cells.
