Long-term impact of COVID-19 on cardiac and pulmonary autonomic function in hypertensive individuals

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Objective Long-term impact of COVID-19 on cardiac and pulmonary autonomic function in patients with systemic arterial hypertension (SAH) was evaluated a cross-sectional study 52 individuals. Methods Participants were allocated to two groups based history. They underwent heart rate variability the 24-hour Holter, lung assessed by spirometry functional capacity (CF) cardiopulmonary exercise test. Results Was revealed worsened COVID-19-recovered SAH patients, indicated lower forced expiratory volume first second (FEV1) rates [2.3 (1.9–2.6) vs. 2.5 (2.2–3.0), p < 0.05)] FEV1/[81.8 (77.5–83.9) vs. 84.6 (80.8–87.7) 0.05)], 30% showing restrictive disorder. However, no significant differences found control. A positive moderate association between VO_2peak FEV1 noted (r = 0.50 0.05), 0V% index negative =-0,55 0.05). Conclusion Findings suggest mild may not cause long-term HRV changes. there is worsening function, presence mainly disorder cases.

Language: Английский

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Heart Rate Variability during Virtual Reality Activity in Individuals after Hospitalization for COVID-19: A Cross-Sectional Control Study

Electronics, Journal Year: 2023, Volume and Issue: 12(8), P. 1925 - 1925

Published: April 19, 2023

(1) Background: COVID-19 can lead to many complications, including cardiorespiratory complications and dysautonomia. This be assessed by heart rate variability (HRV), which reflects the autonomic nervous system. There are different possibilities for physical rehabilitation after COVID, one of that has been growing fast is use Virtual reality (VR) rehabilitation. VR may represent an innovative effective tool minimize deficits could permanent disabilities in patients outpatient services. The aim this protocol establish whether practicing a task using game with body movements influences physiological variables, such as rate, HRV, oxygen saturation, blood pressure, perceptual variables during exercise individuals post-hospitalization COVID. (2) Methods: cross-sectional study evaluated divided into two groups, group healthy control group. Subjects underwent session task, were measured rest, activity, recovery. In addition, considering influence age HRV impact COVID-19, we participants age. (3) Results: all indices both increase sympathetic decrease parasympathetic activity found VR. Additionally, older post-COVID-19 performed worse non-linear indices, peripheral rating perceived exertion (RPE). (4) Conclusions: positively affects therefore utilized secure hospitalization COVID-19. system patients’ post-hospitalization, partly due higher BMI reduced capacity population, affecting their ability perform activities. Other important observations RPE exercise, reflect altered responses. Taken together high reporting fatigue finding, usually lower compared non-VR strengthens potential patients.

Language: Английский

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Applicability of heart rate variability for cardiac autonomic assessment in long-term COVID patients: A systematic review

Journal of Electrocardiology, Journal Year: 2023, Volume and Issue: 82, P. 89 - 99

Published: Dec. 12, 2023

Language: Английский

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Investigating autonomic nervous system dysfunction among patients with post-COVID condition and prolonged cardiovascular symptoms

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 9, 2023

Heart Rate Variability (HRV) and arterial pressure (AP) variability their responses to head-up tilt test (HUTT) were investigated in Post-COVID-19 syndrome (PCS) patients reporting tachycardia and/or postural hypotension. Besides tachycardia, PCS also showed attenuation of the following HRV parameters: RMSSD [square root mean sum squares differences between adjacent normal-to-normal (NN) intervals] from statistical measures; power RR (beat-to-beat interval) spectra at HF (high frequency) linear method spectral analysis; occurrence 2UV (two unlike variation) pattern nonlinear symbolic new family statistics named sample entropy, when compared control subjects. Basal AP LF (low systolic similar subjects, while 0 V (zero patterns analysis exacerbated patients. Despite a decrease RMSSD, no parameter changed during HUTT reassessed after 6 months higher percentage RR. Moreover, lower AP, elicited HR (heart rate) identical The suggest an autonomic dysfunction with sympathetic predominance In contrast, lack indices indicates marked impairment control. Of note, reassessment that noxious effect COVID-19 on tended fade over time.

Language: Английский

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Orthostatic Intolerance after COVID-19 Infection: Is Disturbed Microcirculation of the Vasa Vasorum of Capacitance Vessels the Primary Defect?

Medicina, Journal Year: 2022, Volume and Issue: 58(12), P. 1807 - 1807

Published: Dec. 8, 2022

Following COVID-19 infection, a substantial proportion of patients suffer from persistent symptoms known as Long COVID. Among the main are fatigue, cognitive dysfunction, muscle weakness and orthostatic intolerance (OI). These also occur in myalgic encephalomyelitis/chronic fatigue (ME/CFS). OI is highly prevalent ME/CFS develops early during or after acute infection. The causes for unknown autonomic dysfunction hypothetically assumed to be primary cause, presumably consequence neuroinflammation. Here, we propose an alternative, vascular mechanism underlying cause We assume that capacitance vessel system, which plays key role physiologic regulation, becomes dysfunctional due disturbance microvessels vasa vasorum, supply large parts wall those vessels. microcirculatory found resulting endothelial microthrombus formation rheological disturbances blood cells (altered deformability), affects vasorum impair function In attempt compensate deficit, sympathetic activity overshoots further worsen OI, vicious circle maintains OI. stress, turn, pathophysiology ME/CFS.

Language: Английский

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How did coronavirus disease 2019 affect autonomic balance in young individuals? Analysis by heart rate variability

Revista da Associação Médica Brasileira, Journal Year: 2024, Volume and Issue: 70(10)

Published: Sept. 30, 2024

The aim of this study was to demonstrate the effect coronavirus disease 2019 on cardiovascular autonomic system using heart rate variability in young individuals.

Language: Английский

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Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Abstract This study investigated the impact of mild COVID-19 on HRV in groups stratified by time after infection and to compare a healthy group same age without previous virus need hospitalization. is cross-sectional study. We divided sample into four groups: control (CG) ( n = 31), 1 (G1): ≤6 weeks 34), 2 (G2): 2–6 months 30), 3 (G3): 7–12 35) infection. For analysis, we used indices linear (time frequency domain) non-linear analysis. comparisons between groups, ANOVA one way test or Kruskal–Wallis was according data distribution. The effect size calculated based Cohen’s d η . Simple multiple regressions were performed investigate interaction clinical outcomes parameters. A total 130 individuals included. Groups G1 G2 showed less parasympathetic modulation when compared CG p < 0.05), while G3 an increase 0.05). Moderate large sizes found Cohen regression models identified duration as significant predictors for RMSSD (adjusted R 0.227) SD1 0.242), SDNN 0.213). BMI, hypertension, dyslipidemia non-significant all models. HF (n.u.), consistently significant, with stress emerging predictor Model 0.143). recovery since diagnosis influences from HRV, suggesting transient disease autonomic nervous system.

Language: Английский

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A descriptive study of the clinical impacts on COVID-19 survivors using telemonitoring (The TeleCOVID Study)

Frontiers in Medical Technology, Journal Year: 2023, Volume and Issue: 5

Published: March 20, 2023

There is increasing evidence that COVID-19 survivors are at increased risk of experiencing a wide range cardiovascular complications post infection; however, there no validated models or clear guidelines for remotely monitoring the cardiac health survivors.This study aims to test virtual, in-home healthcare model care detection clinical symptoms and impacts on survivors. It also demonstrate system usability feasibility.This open label, prospective, descriptive was conducted in South Western Sydney. Included were patients admitted hospital with diagnosis between June 2021 November 2021. Eligible participants after consent provided pulse oximeter measure oxygen saturation S-Patch EX monitor their electrocardiogram (ECG) duration 3 months. Data transmitted real-time mobile phone via Bluetooth technology results sent team cloud-based platform. All data reviewed timely manner by investigator team, related symptoms, such as reduction arrhythmia.This designed feasibility real setting implementation, enabling develop utilise detect survivors.During period, 23 participation. Out which 19 commenced monitoring. Sixteen 81 (73.6%) valid tests included analysis amongst them seven detected artificial intelligence have arrhythmias but not clinically symptomatic. The had higher occurrence supraventricular ectopy, most took least 2 before detection. Notably, arrhythmia significantly more than those without [t-test, t (13) = 2.29, p < 0.05].Preliminary observations identified prolonged 7 out first 16 who completed months follow-up. This has allowed early escalation treating doctors further investigations interventions.

Language: Английский

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Autonomic Modulation, Spontaneous Baroreflex Sensitivity and Fatigue in Young Men After COVID-19

Physiological Research, Journal Year: 2023, Volume and Issue: 72(3)

Published: June 30, 2023

Impaired autonomic modulation and baroreflex sensitivity (BRS) have been reported during after COVID-19. Both impairments are associated with negative cardiovascular outcomes. If these were to exist undetected in young men COVID-19, they could lead Fatigue is dysfunction It unclear if fatigue can be used as an indicator of impaired BRS This study aims compare parasympathetic modulation, sympathetic between who had COVID-19 versus controls determine BRS. Parasympathetic the high-frequency power R-R intervals (lnHFR-R), low-frequency systolic blood pressure variability (LFSBP), -index measured by spectral density analysis. These variables compared 20 24 controls. Independent t-tests Mann-Whitney U tests indicated no significant difference control group in: lnHFR-R, P=0.20; LFSBP, P=0.11, -index, P=0.20. was not or There modulations did seem Findings suggest that might at increased risk from COVID-19-related dysautonomia

Language: Английский

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Cardiac Autonomic Function in Long COVID-19 Using Heart Rate Variability: An Observational Cross-Sectional Study

Published: Nov. 21, 2022

Background: Heart rate variability is a non-invasive, measurable, and established autonomic nervous system test. Long-term COVID-19 sequelae are unclear; however, acute symptoms have been studied. Objectives: To determine cardiac differences between long patients heathy controls evaluate associations among symptoms, comorbidities, laboratory findings. Methods: This single-center study included healthy controls. The heart (HRV), quantitative marker of activity, was monitored for 24 h using an ambulatory electrocardiogram system. HRV indices were compared case control groups. Symptom frequency inflammatory markers evaluated. significance level 5% (p-value 0.05) adopted. Results: A total 47 to 42 Patients averaged 43.8 (SD14.8) years old, 60.3% female. In total, 52.5% had moderate illness. Post-exercise dyspnea most common (71.6%), 53.2% lacked comorbidities. 4 times more dyslipidemia. CNP, D-dimer, CRP levels elevated (p-values 0.0098, 0.0023, 0.0015, respectively). group greater SDNN24 SDANNI (OR = 0.98 (0.97 0.99; p 0.01)). Increased low-frequency (LF) in 1.002 (1.0001 1.004; 0.030)) high-frequency (HF) the 0.987 (0.98 0.995; 0.001)) also associated. Conclusions: with lower HF values than individuals. These variations associated increased parasympathetic which may be related

Language: Английский

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