Switching Neuron Contributions to Second Network Activity DOI Creative Commons
Savanna-Rae H. Fahoum, Dawn M. Blitz

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 7, 2023

Abstract Network flexibility is important for adaptable behaviors. This includes neuronal switching, where neurons alter their network participation, including changing from single-to dual-network activity. Understanding the implications of switching requires determining how a neuron interacts with each its networks. Here, we tested 1) whether “home” and second networks, operating via divergent rhythm generation mechanisms, regulate neuron, 2) if recruited modulation intrinsic properties, contributes to or pattern in new network. Small, well-characterized feeding-related networks (pyloric, ∼1 Hz; gastric mill, ∼0.1 Hz) identified modulatory inputs make isolated crab ( Cancer borealis ) stomatogastric nervous system (STNS) useful model study switching. In particular, neuropeptide Gly 1 -SIFamide switches lateral posterior (LPG) (2 copies) pyloric-only dual-frequency pyloric/gastric mill (fast/slow) activity LPG properties. Using current injections manipulate activity, found that but not pyloric, regulated intrinsically generated slow bursting. Conversely, selective elimination both using photoinactivation revealed firing frequencies was necessary coordination. However, alone sufficient produce distinct Thus, modulated properties underlying participation may constrain which can Further, recruitment occur states it actively contribute output. New Noteworthy We used small, investigate interactions between rhythmic switch participation. For into only Additionally, coordinate neurons, levels. regulation be selective, necessarily simply follower additional

Language: Английский

Improving the study of brain-behavior relationships by revisiting basic assumptions DOI Creative Commons
Christiana Westlin, Jordan E. Theriault, Yuta Katsumi

et al.

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(3), P. 246 - 257

Published: Feb. 2, 2023

Neuroimaging research has been at the forefront of concerns regarding failure experimental findings to replicate. In study brain-behavior relationships, past failures find replicable and robust effects have attributed methodological shortcomings. Methodological rigor is important, but there are other overlooked possibilities: most published studies share three foundational assumptions, often implicitly, that may be faulty. this paper, we consider empirical evidence from human brain imaging non-human animals calls each assumption into question. We then opportunities for a science relationships await if scientists ground their efforts in revised assumptions supported by current evidence.

Language: Английский

Citations

95
Virtual brain twins: from basic neuroscience to clinical use DOI Creative Commons
Huifang Wang, Paul Triebkorn, Martin Breyton

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(5)

Published: Feb. 27, 2024

ABSTRACT Virtual brain twins are personalized, generative and adaptive models based on data from an individual’s for scientific clinical use. After a description of the key elements virtual twins, we present standard model personalized whole-brain network models. The personalization is accomplished using subject’s imaging by three means: (1) assemble cortical subcortical areas in subject-specific space; (2) directly map connectivity into models, which can be generalized to other parameters; (3) estimate relevant parameters through inversion, typically probabilistic machine learning. We use healthy ageing five diseases: epilepsy, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease psychiatric disorders. Specifically, introduce spatial masks demonstrate their physiological pathophysiological hypotheses. Finally, pinpoint challenges future directions.

Language: Английский

Citations

26
The enigmatic HCN channels: A cellular neurophysiology perspective DOI Creative Commons
Poonam Mishra, Rishikesh Narayanan

Proteins Structure Function and Bioinformatics, Journal Year: 2023, Volume and Issue: 93(1), P. 72 - 92

Published: Nov. 19, 2023

Abstract What physiological role does a slow hyperpolarization‐activated ion channel with mixed cation selectivity play in the fast world of neuronal action potentials that are driven by depolarization? That puzzling question has piqued curiosity physiology enthusiasts about cyclic nucleotide‐gated (HCN) channels, which widely expressed across body and especially neurons. In this review, we emphasize need to assess HCN channels from perspective how they respond time‐varying signals, while also accounting for their interactions other co‐expressing receptors. First, illustrate unique structural functional characteristics allow them mediate negative feedback loop neurons express in. We present several implications response including gain, voltage sag rebound, temporal summation, membrane potential resonance, inductive phase lead, spike triggered average, coincidence detection. Next, argue overall impact on critically relies Interactions intrinsic oscillations, earning “pacemaker channel” moniker, regulate frequency adaptation, plateau potentials, neurotransmitter release presynaptic terminals, initiation at axonal initial segment. explore spatially non‐homogeneous subcellular distributions different subtypes Finally, discuss plasticity is prevalent can encoding, homeostatic, neuroprotective functions neuron. summary, form an important class diversity owing gating kinetics made puzzle first place.

Language: Английский

Citations

12
Switching neuron contributions to second network activity DOI
Savanna-Rae H. Fahoum, Dawn M. Blitz

Journal of Neurophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Network flexibility is important for adaptable behaviors. This includes neuronal switching, where neurons alter their network participation, including changing from single- to dual-network activity. Understanding the implications of switching requires determining how a neuron interacts with each its networks. Here, we tested 1) whether "home" and second networks, operating via divergent rhythm generation mechanisms, regulate neuron, 2) if recruited modulation intrinsic properties, contributes or pattern in new network. Small, well-characterized feeding-related networks (pyloric, ~1 Hz; gastric mill, ~0.1 Hz) identified modulatory inputs make isolated crab ( Cancer borealis) stomatogastric nervous system (STNS) useful model study switching. In particular, neuropeptide Gly 1 -SIFamide switches lateral posterior (LPG) (2 copies) pyloric-only dual-frequency pyloric/gastric mill (fast/slow) activity LPG properties. Using current injections manipulate activity, found that but not pyloric, regulated intrinsically generated slow bursting. Conversely, selective elimination both using photoinactivation revealed firing frequencies was necessary coordination. However, alone sufficient produce distinct Thus, modulated properties underlying participation may constrain which can Further, recruitment occur states it actively contribute output.

Language: Английский

Citations

4
Luteolin ameliorates pentetrazole-induced seizures through the inhibition of the TLR4/NF-κB signaling pathway DOI
Yahong Cheng,

Yiyuan Zhang,

Puxin Huang

et al.

Epilepsy Research, Journal Year: 2024, Volume and Issue: 201, P. 107321 - 107321

Published: Feb. 14, 2024

Language: Английский

Citations

4
Network motifs in cellular neurophysiology DOI
Divyansh Mittal, Rishikesh Narayanan

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(7), P. 506 - 521

Published: May 28, 2024

Language: Английский

Citations

4
The Role of Glutamate and Blood–Brain Barrier Disruption as a Mechanistic Link between Epilepsy and Depression DOI Creative Commons
Benjamin F. Gruenbaum,

Antonia Schonwald,

Matthew Boyko

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(14), P. 1228 - 1228

Published: July 21, 2024

Epilepsy is associated with substantial neuropsychiatric impairments that persist long after the onset of condition, significantly impacting quality life. The goal this review was to uncover how pathological consequences epilepsy, such as excessive glutamate release and a disrupted blood-brain barrier (BBB), contribute emergence disorders. We hypothesize epilepsy induces dysfunctional BBB through hyperexcitation, which then further amplifies post-ictal levels and, thus, triggers neurodegenerative processes. This identifies determinants concentration in brain explores potential therapeutic interventions restore integrity. Our focus on restoration guided by premise it may improve regulation, consequently mitigating neurotoxicity contributes symptoms.

Language: Английский

Citations

4
Breaking Balance: Synaptic Interneuron Properties Shift the E-I Balance in FCD I Epilepsy DOI Open Access
Sarah F. Muldoon

Epiliepsy currents/Epilepsy currents, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

[Box: see text]

Language: Английский

Citations

0
Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens DOI
Steven T. Miller, Christian B. Macdonald, Srivatsan Raman

et al.

Cell chemical biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Contribution of membrane-associated oscillators to biological timing at different timescales DOI Creative Commons
Monika Stengl, Anna C. Schneider

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

Environmental rhythms such as the daily light-dark cycle selected for endogenous clocks. These clocks predict regular environmental changes and provide basis well-timed adaptive homeostasis in physiology behavior of organisms. Endogenous are oscillators that based on positive feedforward negative feedback loops. They generate stable even under constant conditions. Since weak interactions between allow autonomous synchronization, coupling/synchronization provides self-organized physiological timing. Amongst most thoroughly researched circadian clock neurons mammals insects. comprise nuclear clockworks transcriptional/translational loops (TTFL) ∼24 h gene expression entrained to day-night cycle. It is generally assumed this TTFL clockwork drives all oscillations within cells, being any rhythm Instead current gene-based hierarchical model we here a systems view We suggest coupled system posttranslational loop (PTFL) oscillators/clocks run at multiple timescales governs adaptive, dynamic behavior. focus mammalian insect timescales. neuronal plasma membrane-associated signalosomes constitute specific PTFL localized but interlinked membrane potential intracellular messengers with frequencies. In each neuron multiscale form temporally structured oscillatory network common complex frequency-band comprising superimposed oscillations. Coupling oscillator/clock next level complexity an network. This systemic molecular cellular suggested cycles through homeostatic setpoints characteristic hallmark. propose mechanisms plasticity maintain stability these setpoints, whereas Hebbian enables switching via coupling factors, like biogenic amines and/or neuropeptides. reprogram new frequency, setpoint. Our novel hypothesis up experimental challenge.

Language: Английский

Citations

3