Physiological and pathological roles of lipogenesis

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(5), P. 735 - 759

Published: May 4, 2023

Language: Английский

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Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance

Oncogenesis, Journal Year: 2022, Volume and Issue: 11(1)

Published: Aug. 9, 2022

Abstract Lipids are essential constituents for malignant tumors, as they absolutely required tumor growth and dissemination. Provided by the microenvironment (TME) or cancer cells themselves through activation of de novo synthesis pathways, orchestrate a large variety pro-tumorigenic functions. Importantly, TME cells, especially immune cancer-associated fibroblasts (CAFs) adipocytes (CAAs), also prone to changes in their lipid content, which hinder promote aggressiveness. In this review, we address significant findings contribution progression towards metastatic disease poor response therapeutic treatments. We highlight benefits targeting pathways preclinical models slow down metastasis development overcome chemo-and immunotherapy resistance.

Language: Английский

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Exploiting the Twisted Intramolecular Charge Transfer Effect to Construct a Wash-Free Solvatochromic Fluorescent Lipid Droplet Probe for Fatty Liver Disease Diagnosis

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(9), P. 3881 - 3887

Published: Feb. 22, 2022

The prominent pathological feature of fatty liver disease lesions is excessive fat accumulation in lipid droplets hepatocytes. Thus, developing fluorescent droplet-specific probes with high permeability and a imaging contrast provides robust tool for diagnosing diseases. Herein, we rationally developed novel donor-acceptor lipophilic probe ANI photostability wash-free visualization characteristics. showed typical twisted intramolecular charge transfer effect very faint fluorescence high-polar solvents, but dramatically boosted emissions low-polar environments. solvatochromic can selectively light up manner. Further use to reveal the significantly large size tissues from model mice was successfully demonstrated. remarkable performances rendered an alternative accurately evaluating intraoperative diagnosis.

Language: Английский

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Lipid droplets and cellular lipid flux

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(3), P. 331 - 345

Published: March 1, 2024

Language: Английский

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Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Jan. 27, 2023

Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic kingdom. They have a central role in regulating lipid metabolism and undergo dynamic turnover of biogenesis breakdown to meet cellular requirements for fatty acids, including polyunsaturated acids. Polyunsaturated acids esterified membrane phospholipids define fluidity can be released by activity phospholipases A

Language: Английский

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Diabetes mellitus—Progress and opportunities in the evolving epidemic

Cell, Journal Year: 2024, Volume and Issue: 187(15), P. 3789 - 3820

Published: July 1, 2024

Language: Английский

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Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024

Journal of clinical lipidology, Journal Year: 2024, Volume and Issue: 18(3), P. e320 - e350

Published: April 24, 2024

BACKGROUNDThis joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk.METHODSThis is based upon scientific evidence, perspectives authors, peer OMA NLA leadership.RESULTSAmong individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles.CONCLUSIONSObesity increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. Among patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD. This risk. leadership. particles.

Language: Английский

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Futile cycles: Emerging utility from apparent futility

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1184 - 1203

Published: April 1, 2024

Futile cycles are biological phenomena where two opposing biochemical reactions run simultaneously, resulting in a net energy loss without appreciable productivity. Such state was presumed to be aberration and thus deemed an energy-wasting "futile" cycle. However, multiple pieces of evidence suggest that utilities emerge from futile cycles. A few established functions control metabolic sensitivity, modulate homeostasis, drive adaptive thermogenesis. Yet, the physiological regulation, implication, pathological relevance most remain poorly studied. In this review, we highlight abundance versatility propose classification scheme. We further discuss energetic implications various their impact on basal rate, bona fide tentative pathophysiological implications, putative drug interactions.

Language: Английский

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Futile lipid cycling: from biochemistry to physiology

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(5), P. 808 - 824

Published: March 8, 2024

Language: Английский

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Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024

Obesity Pillars, Journal Year: 2024, Volume and Issue: 10, P. 100108 - 100108

Published: March 12, 2024

This joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk. is based upon scientific evidence, perspectives authors, peer OMA NLA leadership. Among individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles. increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD.

Language: Английский

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