Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(5), P. 250 - 251
Published: March 3, 2023
Language: Английский
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(3), P. 526 - 540.e7
Published: Jan. 24, 2024
Language: Английский
Citations
31
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1184 - 1203
Published: April 1, 2024
Futile cycles are biological phenomena where two opposing biochemical reactions run simultaneously, resulting in a net energy loss without appreciable productivity. Such state was presumed to be aberration and thus deemed an energy-wasting "futile" cycle. However, multiple pieces of evidence suggest that utilities emerge from futile cycles. A few established functions control metabolic sensitivity, modulate homeostasis, drive adaptive thermogenesis. Yet, the physiological regulation, implication, pathological relevance most remain poorly studied. In this review, we highlight abundance versatility propose classification scheme. We further discuss energetic implications various their impact on basal rate, bona fide tentative pathophysiological implications, putative drug interactions.
Language: Английский
Citations
27
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(2), P. 468 - 491
Published: Nov. 10, 2023
G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and Takeda receptor 5 (TGR5) is member this family. As receptor, TGR5 widely distributed in different parts the human body plays vital role regulating metabolism, including processes energy consumption, weight loss blood glucose homeostasis. Recent studies have shown that an important lipid metabolism disorders such as fatty liver, obesity diabetes. With global situation becoming more serious, comprehensive explanation mechanism filling gaps knowledge concerning clinical ligand drugs urgently needed. In review, we mainly explain anti-obesity to promote further study target, show electron microscope structure review recent on ligands illustrate specific binding between sites ligands, which can effectively provide new ideas for research drug research.
Language: Английский
Citations
32
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(8), P. 1764 - 1778.e9
Published: June 17, 2024
Language: Английский
Citations
10
Genomics, Journal Year: 2025, Volume and Issue: 117(2), P. 110988 - 110988
Published: Jan. 5, 2025
GLP-1 receptor agonists (GLP-1RA) have been extensively utilized in the management of body weight individuals with obesity. Circular RNA (circRNA), a class covalently closed molecules, has garnered increasing attention for its potential role pathogenesis However, specific mechanisms through which circRNA contributes to GLP-1RA-induced loss remains elusive. High-throughput sequencing analyzed epididymal adipose tissue from obese mice under high-fat, and GLP-1RA intervention (600 μg/kg/d). The functions differentially expressed (DE) genes were enriched analyzed. circRNA-miRNA-mRNA interaction network was constructed Cytoscape, KEGG pathway gene enrichment validated via western blotting. A total 644 DEcircRNAs, 186 DEmiRNAs, 3474 DEmRNAs identified. Based on ceRNA score calculations, diagrams constructed. Gene Ontology (GO) analysis revealed that DERNAs linked lipid fatty acid metabolism. DE within pairs metabolism pathways, especially PI3K-Akt AMPK signaling pathways. induced phosphorylation AKT AMPK, subsequently led reduction SREBP-1, ACC, FAS. might activate pathways combat obesity circRNAs.
Language: Английский
Citations
1
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 2146 - 2155.e5
Published: July 30, 2024
Language: Английский
Citations
6
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 755, P. 109975 - 109975
Published: March 24, 2024
Language: Английский
Citations
5
Cell Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
5
Molecular Metabolism, Journal Year: 2024, Volume and Issue: 83, P. 101925 - 101925
Published: March 26, 2024
Estrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenergetics and metabolism, perturbations its activity have been associated with metabolic diseases. While several coactivators corepressors ERRα identified to date, knowledge gap remains understanding extent which cooperates coregulators control gene expression. Herein, we mapped primary chromatin-bound interactome mouse liver. RIME (Rapid Immuno-precipitation Mass spectrometry Endogenous proteins) analysis using liver samples from two circadian time points was used catalog ERRα-interacting proteins on chromatin. The genomic crosstalk between cofactors precise programs explored through cross-examination genome-wide binding profiles chromatin immunoprecipitation-sequencing (ChIP-seq) studies. dynamic interplay newly uncovered cofactor Host cell factor C1 (HCFC1) further investigated by loss-of-function studies hepatocytes. Characterization hepatic led identification 48 interactors 42 were previously unknown including HCFC1. Interrogation available ChIP-seq highlighted oxidative phosphorylation (OXPHOS) under complex regulatory network multiple cofactors. HCFC1 found bind large set common genes, only small fraction showed their colocalization, predominately near start sites genes particularly enriched for components mitochondrial respiratory chain. Knockdown demonstrated inverse actions OXPHOS expression ultimately dictating impact respiration. Our work unveils repertoire partners comprised modifiers transcription factors thus advancing our how regulates programs.
Language: Английский
Citations
4
Cell Metabolism, Journal Year: 2025, Volume and Issue: 37(3), P. 742 - 757.e8
Published: Feb. 17, 2025
Language: Английский
Citations
0