Cited by Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

Amino acid metabolism in tumor biology and therapy DOI

Jie Chen,

Likun Cui,

Shaoteng Lu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 13, 2024

Abstract Amino acid metabolism plays important roles in tumor biology and therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis immunity by acting as nutrients, signaling molecules, could also regulate gene transcription epigenetic modification. Therefore, targeting will provide new ideas for treatment become an therapeutic approach after surgery, radiotherapy, chemotherapy. In this review, we systematically summarize the recent progress of malignancy their interaction with signal pathways well effect on microenvironment Collectively, highlight potential application future expectation.

Language: Английский

Citations

Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy DOI

Weiping Zou, Douglas R. Green

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(7), P. 1101 - 1113

Published: June 29, 2023

Language: Английский

Citations

Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment DOI

Guanghong Luo,

Xing Li, Jihui Lin

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15449 - 15465

Published: Aug. 2, 2023

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death evoke responses, providing specific antitumor effects. However, strategies that exploit effects multiion are rare. We herein prepared pH-responsive nanomodulator by coloading curcumin (CU, Ca

Language: Английский

Citations

How protons pave the way to aggressive cancers DOI

Pawel Swietach, Ebbe Boedtkjer, Stine F. Pedersen

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(12), P. 825 - 841

Published: Oct. 26, 2023

Language: Английский

Citations

pH sensing at the intersection of tissue homeostasis and inflammation DOI

Stephanie Hajjar, Xu Zhou

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(10), P. 807 - 825

Published: Sept. 14, 2023

Language: Английский

Citations

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization DOI

Hanchu Xiong,

Yanan Zhai,

Yimei Meng

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216732 - 216732

Published: Feb. 14, 2024

Language: Английский

Citations

Lactate and lactylation in cancer DOI

Jie Chen, Ziyue Huang,

Ya Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

Citations

Mechanisms of alkaliptosis DOI

Fangquan Chen, Rui Kang, Jiao Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 4, 2023

Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various exist, including surgery, radiotherapy, chemotherapy, immunotherapy combination therapies, there remains need develop therapies that target regulated cell death pathways eliminate cancer cells while preserving normal cells. Alkaliptosis, pH-dependent process triggered by small molecular compound JTC801, has been identified as novel approach malignant tumor treatment, particularly in pancreatic cancer. Two signaling pathways, NF-κB-CA9 pathway ATP6V0D1-STAT3 pathway, contribute induction of alkaliptosis. This review summarizes recent developments our understanding alkaliptosis signals, mechanisms, modulation, explores its context-dependent effects on drug resistance, inflammation, immunity. By providing deeper heterogeneity plasticity this information holds promise informing design more anti-tumor therapies.

Language: Английский

Citations

Targeting methionine metabolism in cancer: opportunities and challenges DOI

Peng Bin, Chuanlong Wang, Hangchao Zhang

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 395 - 405

Published: April 5, 2024

Language: Английский

Citations

Metabolic engineering for optimized CAR-T cell therapy DOI

Sarah McPhedran,

Gillian Carleton, Julian J. Lum

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(3), P. 396 - 408

Published: Feb. 22, 2024

Language: Английский

Citations