Cancer metastasis as a non-healing wound DOI Creative Commons
Matthew Deyell, Christopher Garris, Ashley M. Laughney

et al.

British Journal of Cancer, Journal Year: 2021, Volume and Issue: 124(9), P. 1491 - 1502

Published: March 17, 2021

Abstract Most cancer deaths are caused by metastasis: recurrence of disease disseminated tumour cells at sites distant from the primary tumour. Large numbers released tumour, even during early stages growth. However, only a minority survive as potential seeds for future metastatic outgrowths. These must adapt to relatively inhospitable microenvironment, evade immune surveillance and progress micro- macro-metastatic stage generate secondary A pervasive driver this transition is chronic inflammatory signalling emanating themselves. signals can promote migration engagement stem progenitor cell function, events that also central wound healing response. In review, we revisit concept non-healing wound, first introduced Virchow in 19th century, with new cell-intrinsic perspective on inflammation focus metastasis. Cellular responses both metastasis tightly regulated crosstalk surrounding microenvironment. Targeting or restoring canonical could represent novel strategy prevent lethal spread cancer.

Language: Английский

Applications of organoids for cancer biology and precision medicine DOI

Yuan‐Hung Lo,

Kasper Karlsson, Calvin J. Kuo

et al.

Nature Cancer, Journal Year: 2020, Volume and Issue: 1(8), P. 761 - 773

Published: Aug. 18, 2020

Language: Английский

Citations

135
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain DOI
Jinxiang Dai, Patrick J. Cimino, Kenneth Gouin

et al.

Nature Cancer, Journal Year: 2021, Volume and Issue: 3(1), P. 25 - 42

Published: Dec. 24, 2021

Language: Английский

Citations

88
Over a century of cancer research: Inconvenient truths and promising leads DOI Creative Commons
Carlos Sonnenschein, Ana M. Soto

PLoS Biology, Journal Year: 2020, Volume and Issue: 18(4), P. e3000670 - e3000670

Published: April 1, 2020

Despite over a century of intensive efforts, the great gains promised by War on Cancer nearly 50 years ago have not materialized. Since 1999, we analyzed lack progress in explaining and "curing" cancer examining merits premises that determine how is understood treated. Our ongoing critical analyses aimed at clarifying sources misunderstandings root puzzle while providing plausible comprehensive biomedical perspective as well new theory carcinogenesis compatible with evolutionary theory. In this essay, explain theory, tissue organization field (TOFT), can help chart path to for researchers features remain unexplainable from still hegemonic somatic mutation (SMT) its variants. Of equal significance, underlying TOFT offer perspectives basic biological phenomena.

Language: Английский

Citations

78
Enteric-coated gelatin nanoparticles mediated oral delivery of 5-aminosalicylic acid alleviates severity of DSS-induced ulcerative colitis DOI Open Access
Anas Ahmad, Md. Meraj Ansari, Rakesh K. Mishra

et al.

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 119, P. 111582 - 111582

Published: Oct. 6, 2020

Language: Английский

Citations

77
Cancer metastasis as a non-healing wound DOI Creative Commons
Matthew Deyell, Christopher Garris, Ashley M. Laughney

et al.

British Journal of Cancer, Journal Year: 2021, Volume and Issue: 124(9), P. 1491 - 1502

Published: March 17, 2021

Abstract Most cancer deaths are caused by metastasis: recurrence of disease disseminated tumour cells at sites distant from the primary tumour. Large numbers released tumour, even during early stages growth. However, only a minority survive as potential seeds for future metastatic outgrowths. These must adapt to relatively inhospitable microenvironment, evade immune surveillance and progress micro- macro-metastatic stage generate secondary A pervasive driver this transition is chronic inflammatory signalling emanating themselves. signals can promote migration engagement stem progenitor cell function, events that also central wound healing response. In review, we revisit concept non-healing wound, first introduced Virchow in 19th century, with new cell-intrinsic perspective on inflammation focus metastasis. Cellular responses both metastasis tightly regulated crosstalk surrounding microenvironment. Targeting or restoring canonical could represent novel strategy prevent lethal spread cancer.

Language: Английский

Citations

74