Recovery
of
rare-earth
elements
(REEs)
from
REE-containing
waste
streams
is
vital
for
resource
sustainable
supply
and
environmental
protection.
Microbial
biosorption
by
utilizing
lanthanide
binding
tags
(LBTs)
immobilized
on
the
cell
surface
selectively
capturing
REEs
offers
an
appealing
option,
yet
this
technology
currently
restricted
limited
adsorption
capacity.
Here,
we
report
a
curli
display
strategy
to
drastically
raise
extracellular
LBT
loading
engineered
cells
using
Escherichia
coli
as
model.
The
bacteria
with
abundant
self-assembled
LBT-loaded
exhibited
over
2-fold
higher
terbium
capacity
than
control
surface-displayed
proteins.
It
rivals
abiotic
sorbents
in
but
much
selectivity.
Moreover,
biosorbent
still
retained
94%
after
six
consecutive
sorption–desorption
cycles
was
successfully
used
recover
simulated
acid
mine
drainage.
A
similar
curli-displayed
proteins
metal
also
applied
recovery
gold
ions
water,
implying
that
such
may
serve
universal
biological
platform
complicated
water
matrices.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 31, 2024
Approved
anticancer
drugs
typically
face
challenges
due
to
their
narrow
therapeutic
window,
primarily
because
of
high
systemic
toxicity
and
limited
selectivity
for
tumors.
Prodrugs
are
initially
inactive
drug
molecules
designed
undergo
specific
chemical
modifications.
These
modifications
render
the
until
they
encounter
conditions
or
biomarkers
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(8), P. 2216 - 2241
Published: April 15, 2024
Abstract
As
the
conversion
rate
of
preclinical
studies
for
cancer
treatment
is
low,
user-friendly
models
that
mimic
pathological
microenvironment
and
drug
intake
with
high
throughput
are
scarce.
Animal
key,
but
an
alternative
to
reduce
their
use
would
be
valuable.
Vascularized
tumor-on-chip
combine
great
versatility
scalable
easy
use.
Several
strategies
integrate
both
tumor
vascular
compartments
have
been
developed,
few
used
assess
delivery.
Permeability,
intra/extravasation,
free
circulation
often
evaluated,
imperfectly
recapitulate
processes
at
stake.
Indeed,
targeting
chemoresistance
bypass
must
investigated
design
promising
therapeutics.
In
vitro
help
development
delivery
systems
(DDS)
thus
needed.
They
allow
selecting
good
candidates
before
animal
based
on
rational
criteria
such
as
accumulation,
diffusion
in
tumor,
potency,
well
absence
side
damage.
this
review,
we
focus
vascularized
models.
First,
detail
fabrication,
especially
materials,
cell
types,
coculture
used.
Then,
different
vascularization
described
along
classical
applications
intra/extravasation
or
assessment.
Finally,
current
trends
DDS
discussed
overview
efforts
domain.
Graphical
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
371, P. 85 - 100
Published: May 24, 2024
Lipid
conjugates
have
advanced
the
field
of
lipid-based
nanomedicine
by
promoting
active-targeting
(ligand,
peptide,
antibody),
stability
(PEGylation),
controlled
release
(lipoid
prodrug),
and
probe-based
tracking
(fluorophore).
Recent
findings
indicate
lipid
dissociating
from
upon
encountering
a
biological
environment.
Yet,
implications
for
(pre)clinical
outcomes
remain
unclear.
In
this
study,
using
zebrafish
model
(Danio
rerio),
we
investigated
fate
liposome-incorporated
fluorophore
(LFCs)
after
intravenous
(IV)
administration.
LFCs
having
bilayer
mismatch
relatively
polar
revealed
counter-predictive
Caelyx/Doxil
(clearance
vs.
circulating)
AmBisome-like
liposomes
(scavenger
endothelial
cell
macrophage
uptake).
Findings
on
LFC
(mis)match
Caelyx/Doxil-like
were
supported
translational
intravital
imaging
studies
in
mice.
Importantly,
contradicting
observations
suggest
to
originate
dissociation
vivo,
which
was
Asymmetric
Flow
Field-Flow
Fractionation
(AF4)
liposome-serum
incubation
situ.
Our
data
suggests
that
matching
with
liposome
composition
-
did
not
dissociate
serum
improved
predictive
biodistribution
profiles.
Altogether,
study
highlights
critical
importance
fatty
acid
tail
length
headgroup
moiety
when
selecting
nanomedicine.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(4)
Published: July 1, 2024
Abstract
Radiotherapy
is
an
invaluable
tool
in
the
treatment
of
cancer.
However,
when
used
as
a
monotherapy,
it
fails
to
provide
curative
outcomes.
Chemotherapy
drugs
are
often
included
boost
effects
radiation.
Key
classes
radiosensitizing
include
platinum
compounds,
anthracyclines,
antimetabolites,
taxanes,
topoisomerase
inhibitors,
alkylating
agents,
and
DNA
damage
repair
inhibitors.
Chemoradiotherapy
suffers
from
not
only
systemic
toxicities
chemotherapy
but
also
synergistic
radiation
toxicity
well.
It
critical
deliver
molecules
tumor
cells
while
avoiding
adjacent
healthy
tissues.
Currently,
nanomedicine
provides
avenue
for
specific
delivery
radiosensitizers.
Nanoscale
vehicles
can
be
synthesized
lipids,
polymers,
or
inorganic
materials.
Additionally,
encompasses
stimuli
responsive
particles
including
prodrug
formulation
activation.
Clinically,
radiotherapy
intertwined
with
approved
DOXIL
Abraxane.
Though
many
challenges
remain,
ongoing
progress
evidences
promising
future
both
chemoradiotherapy.
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
Cardiovascular
Emerging
Technologies
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Abstract
Colloidal
drug
aggregates
(CDAs)
are
challenging
in
discovery
due
to
their
unpredictable
formation
and
interference
with
screening
assays.
These
limitations
turned
into
a
strategic
advantage
by
leveraging
CDAs
as
delivery
platform.
This
study
explores
the
deliberate
stabilization
of
for
local
ocular
delivery,
using
modified
smallmolecule
glaucoma
drug.
A
series
timolol
prodrugs
synthesized
self‐assembled
CDAs.
Of
four
prodrugs,
palmitate
have
critical
aggregate
concentration
2.72
µM
sustained
vitro
release
over
28
d.
Timolol
dispersed
throughout
situ
gelling
hyaluronan‐oxime
hydrogel
injected
subconjunctival
space
rat
eyes.
The
intraocular
pressure
is
significantly
reduced
at
least
49
d
single
injection
timolol‐palmitate
compared
6
h
conventional
maleate.
systemic
blood
concentrations
lower,
even
after
h,
CDA‐loaded
versus
free
maleate,
thereby
potentially
reducing
risk
side
effects.
innovative
approach
redefines
role
provides
framework
long‐acting
therapeutics,
shifting
perception
from
challenge
powerful
tool
delivery.
Alopecia
areata
(AA)
is
a
prevalent
autoimmune
condition
that
causes
sudden
hair
loss
and
poses
significant
psychological
challenges
to
affected
individuals.
Current
treatments,
including
corticosteroids
Janus
kinase
inhibitors,
fail
provide
long-term
efficacy
due
adverse
effects
relapse
after
cessation.
This
study
introduces
nanoparticle
(NP)
system
codeliver
diphenylcyclopropenone
(DPCP)
rapamycin
(RAPA)
prodrugs
induce
immune
tolerance
promote
regeneration.
The
results
demonstrated
the
coassembled
NPs
exhibited
uniformity
stability,
were
efficiently
taken
up
by
antigen-presenting
cells
(APCs),
successfully
induced
dendritic
(DCs)
differentiate
into
tolerogenic
phenotypes
in
vitro.
In
vivo
studies
on
mouse
model
of
alopecia
showed
these
significantly
accelerated
transition
follicles
from
telogen
phase
anagen
phase,
promoting
regrowth.
research
presents
promising
therapeutic
strategy
for
AA
offers
insights
treating
diseases
where
autoantigens
are
unclear.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Antidrug
antibodies
(ADAs)
against
biologics
present
a
major
challenge
for
sustained
biotherapy,
including
enzyme
replacement
therapies
and
adeno-associated
virus
(AAV)
gene
therapies.
These
arise
from
undesirable
immune
responses,
leading
to
altered
pharmacokinetics,
reduced
efficacy,
adverse
reactions.
In
this
study,
we
introduced
rationally
designed
lipid-rapamycin
(Rapa)-based
nanovaccine
restore
tolerance
overcome
drug
resistance.
The
significantly
decreased
ADA
responses
when
used
in
tolerogenic
regimen
with
keyhole
limpet
hemocyanin
(KLH),
uricase,
pegylated
AAV8
vector
therapy.
This
approach
facilitated
three
rechallenges
uricase
after
5
week
rest
the
nanovaccine,
thereby
enhancing
its
urate-lowering
efficacy.
Furthermore,
allowed
successful
intravenous
readministration
of
expressing
secreted
embryonic
alkaline
phosphatase
(AAV8-SEAP),
achieving
viral
DNA
transcript
levels
target
tissues.
prompted
antigen-presenting
cells
(APCs)
liver
exhibit
dynamic
changes
CD80,
CD86,
MHCII,
PD-L1,
which
promoted
development
immunoregulatory
T
response
biologic
challenges.
Notably,
exerted
minimal
impact
on
CD8+
cells,
natural
killer
(NK)
NK
preserving
body's
normal
pathogens
tumors.
Overall,
universal
addressed
resistance
by
mitigating
ADA-related
issues,
enabling
prolonged
therapeutic
efficacy
antibodies,
proteins,
