Bacterial Diversity Associated with the Coccolithophorid AlgaeEmiliania huxleyiandCoccolithus pelagicusf.braarudii DOI Creative Commons
David H. Green, Virginia Echavarri‐Bravo,

Debra Brennan

et al.

BioMed Research International, Journal Year: 2015, Volume and Issue: 2015, P. 1 - 15

Published: Jan. 1, 2015

Coccolithophores are unicellular calcifying marine phytoplankton that can form large and conspicuous blooms in the oceans make significant contributions to oceanic carbon cycling atmospheric CO 2 regulation. Despite their importance, bacterial diversity associated with these algae has not been explored for ecological or biotechnological reasons. Bacterial membership of Emiliania huxleyi Coccolithus pelagicus f. braarudii cultures was assessed using cultivation cultivation-independent methods. The communities were species rich compared other cultures. Community analysis identified specific taxa which cooccur all ( Marinobacter Marivita ). Hydrocarbon-degrading bacteria found presence Acidobacteria, Acidimicrobidae, Schlegelella , Thermomonas unprecedented but potentially explained by calcification coccolith production. One strain Acidobacteria cultivated is closely related a isolated from sponge. From this assessment coccolithophores, number opportunities evident, bioprospecting novel such as helping understand relationship between obligate hydrocarbonoclastic occurrence revealing have association may be suitable candidates means improve efficiency mass algal cultivation.

Language: Английский

Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents DOI Creative Commons
Gordon M. Cragg, John M. Pezzuto

Medical Principles and Practice, Journal Year: 2015, Volume and Issue: 25(Suppl. 2), P. 41 - 59

Published: Dec. 17, 2015

Throughout history, natural products have played a dominant role in the treatment of human ailments. For example, legendary discovery penicillin transformed global existence. Presently, comprise large portion current-day pharmaceutical agents, most notably area cancer therapy. Examples include Taxol, vinblastine, and camptothecin. These structurally unique agents function by novel mechanisms action; isolation from sources is only plausible method that could led to their discovery. In addition terrestrial plants as for starting materials, marine environment (e.g., ecteinascidin 743, halichondrin B, dolastatins), microbes bleomycin, doxorubicin, staurosporin), slime molds epothilone B) yielded remarkable chemotherapeutic agents. Irrespective these advances, remains leading cause death worldwide. Undoubtedly, prevention highly preferable treatment. Cancer chemoprevention, use vaccines or inhibit, retard, reverse process carcinogenesis, another important approach easing this formidable public health burden. Similar play an field. There are many examples, including dietary phytochemicals such sulforaphane phenethyl isothiocyanate (cruciferous vegetables) resveratrol (grapes grape products). Overall, product research powerful discovering biologically active compounds with structures action. Given unfathomable diversity nature, it reasonable suggest chemical leads can be generated capable interacting possibly all therapeutic targets.

Language: Английский

Citations

651
Marine natural products DOI Creative Commons
John W. Blunt, Brent R. Copp, Robert A. Keyzers

et al.

Natural Product Reports, Journal Year: 2016, Volume and Issue: 33(3), P. 382 - 431

Published: Jan. 1, 2016

This review of marine natural products for 2014 describes 1378 new compounds and reports structural revisions or assignments absolute configuration previously reported compounds. Since 1965 MNP chemists have made ∼9000 collections worldwide yielding ∼25 700 MNPs. The rate discovery MNPs by region is examined in this review.

Language: Английский

Citations

430
Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms DOI Creative Commons
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl

et al.

Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(7), P. 904 - 936

Published: Jan. 1, 2015

Many organisms team up with symbiotic microbes for defense against predators, parasites, parasitoids, or pathogens. Here we review the known defensive symbioses in animals and microbial secondary metabolites responsible providing protection to host.

Language: Английский

Citations

369
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse DOI
Vinayak Agarwal,

Zachary D. Miles,

Jaclyn M. Winter

et al.

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(8), P. 5619 - 5674

Published: Jan. 20, 2017

Naturally produced halogenated compounds are ubiquitous across all domains of life where they perform a multitude biological functions and adopt diversity chemical structures. Accordingly, diverse collection enzyme catalysts to install remove halogens from organic scaffolds has evolved in nature. Accounting for the different properties four halogen atoms (fluorine, chlorine, bromine, iodine) reactivity their substrates, enzymes performing biosynthetic degradative halogenation chemistry utilize numerous mechanistic strategies involving oxidation, reduction, substitution. Biosynthetic reactions range simple aromatic substitutions stereoselective C–H functionalizations on remote carbon centers can initiate formation complex ring Dehalogenating enzymes, other hand, best known removing man-made organohalogens, yet also function naturally, albeit rarely, metabolic pathways. This review details scope mechanism nature's dehalogenation enzymatic strategies, highlights gaps our understanding, posits new advances field might arise near future.

Language: Английский

Citations

365
The Sponge Hologenome DOI Creative Commons
Nicole S. Webster, Torsten Thomas

mBio, Journal Year: 2016, Volume and Issue: 7(2)

Published: April 22, 2016

A paradigm shift has recently transformed the field of biological science; molecular advances have revealed how fundamentally important microorganisms are to many aspects a host's phenotype and evolution. In process, an era "holobiont" research emerged investigate intricate network interactions between host its symbiotic microbial consortia. Marine sponges early-diverging metazoa known for hosting dense, specific, often highly diverse communities. Here we synthesize current thoughts about environmental evolutionary forces that influence diversity, specificity, distribution symbionts within sponge holobiont, explore physiological pathways contribute holobiont function, describe mechanisms underpin establishment maintenance these partnerships. The collective genomes form hologenome, highlight define sponge's in fact act on genomic interplay different components holobiont.

Language: Английский

Citations

300
Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012 DOI Creative Commons
Yiwen Hu, Jiahui Chen,

Guping Hu

et al.

Marine Drugs, Journal Year: 2015, Volume and Issue: 13(1), P. 202 - 221

Published: Jan. 7, 2015

Every year, hundreds of new compounds are discovered from the metabolites marine organisms. Finding and useful is one crucial drivers for this field research. Here we describe statistics bioactive organisms 1985 to 2012. This work based on our database, which contains information more than 15,000 chemical substances including 4196 natural products. We performed a comprehensive statistical analysis understand characteristics novel detail temporal trends, structures, species distribution, research progress. hope meta-analysis will provide into bioactivity products drug development.

Language: Английский

Citations

238
Elicitation of secondary metabolism in actinomycetes DOI Creative Commons
Usama Ramadan Abdelmohsen, Tanja Grkovic,

Srikkanth Balasubramanian

et al.

Biotechnology Advances, Journal Year: 2015, Volume and Issue: 33(6), P. 798 - 811

Published: June 15, 2015

Genomic sequence data have revealed the presence of a large fraction putatively silent biosynthetic gene clusters in genomes actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on effects biological (co-cultivation), chemical, as well molecular elicitation metabolism actinomycetes. Our covers literature until June 2014 and exemplifies diversity natural products been recovered by such approaches from phylum Actinobacteria.

Language: Английский

Citations

213
Actinobacteria in natural products research: Progress and prospects DOI Creative Commons

Polpass Arul Jose,

Anjisha Maharshi, Bhavanath Jha

et al.

Microbiological Research, Journal Year: 2021, Volume and Issue: 246, P. 126708 - 126708

Published: Jan. 22, 2021

Language: Английский

Citations

166
Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective DOI Creative Commons
Lavinia Donald, Atanas Pipite, Ramesh Subramani

et al.

Microbiology Research, Journal Year: 2022, Volume and Issue: 13(3), P. 418 - 465

Published: July 1, 2022

There is a real consensus that new antibiotics are urgently needed and the best chance for combating antibiotic resistance. The phylum Actinobacteria one of main producers antibiotics, with recent paradigm shift whereby rare actinomycetes have been increasingly targeted as source secondary metabolites discovery antibiotics. However, this review shows genus Streptomyces still largest current producer innovative metabolites. Between January 2015 December 2020, significantly high number novel spp. isolated from different environments, including extreme symbionts, terrestrial soils, sediments also marine mainly invertebrates sediments. This highlights 135 species during 6-year period 108 environment 27 sources. A brief summary pre-treatment methods used successful isolation some discussed, well biological activities total 279 recorded 121 which exhibit diverse activity. greatest originated terrestrial-sourced

Language: Английский

Citations

121
Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds DOI Creative Commons
S. Ramanathan, Arunachalam Kannappan, Chunlei Shi

et al.

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(10), P. 530 - 530

Published: Sept. 23, 2021

The prevalence of antimicrobial resistance reduces the effectiveness drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, viruses. Because burgeoning growth microbes with antimicrobial-resistant traits, there is a dire need to identify develop novel effective agents treat infections from strains. marine environment rich ecological biodiversity can be regarded an untapped resource for prospecting bioactive compounds. Therefore, exploring plays significant role drug development biomedical research. Several earlier scientific investigations have proven that bacterial diversity represents emerging source structurally unique agents. There are several reports on secondary metabolites, many pharmacologically enormous promise developing combat microbial drug-resistant pathogens. In this review, we attempt summarize published articles last twenty-five years (1996–2020) metabolites bacteria evolved environments, sediment, water, fauna, flora.

Language: Английский

Citations

108