The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4819 - 4880

Published: March 28, 2019

The design of nanoparticles is critical for their efficient use in many applications ranging from biomedicine to sensing and energy. While shape size are responsible the properties inorganic nanoparticle core, choice ligands utmost importance colloidal stability function nanoparticles. Moreover, selection employed synthesis can determine final shape. Ligands added after infer both new as well provide enhanced stability. In this article, we a comprehensive review on role with respect morphology, stability, function. We analyze interaction surface different chemical groups, types bonding, dispersibility ligand-coated complex media, reactivity, performance biomedicine, photodetectors, photovoltaic devices, light-emitting sensors, memory thermoelectric applications, catalysis.

Language: Английский

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Targeting Strategies for Tissue-Specific Drug Delivery

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 151 - 167

Published: April 1, 2020

Language: Английский

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Platinum-based drugs for cancer therapy and anti-tumor strategies

Theranostics, Journal Year: 2022, Volume and Issue: 12(5), P. 2115 - 2132

Published: Jan. 1, 2022

Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer.However, the side effects platinum drugs, such as lack selectivity, high systemic toxicity, drug resistance, seriously limit their clinical application.With advancements in nanotechnology chemical synthesis, Pt-based anti-cancer have made great progress cancer therapy recent years.Many strategies relied on mechanism similar to cisplatin achieved some success by modifying existing drugs.Pt-based nanodrugs, nanoclusters, novel mechanisms potential tumor-targeted shown promising results application.In this review, we systematically explored development first-line chemotherapy clinic mechanisms.We also summarize application therapy, emphasizing modification enhance anti-tumor effect.Finally, address challenges faced especially Pt nanocluster-based treatment.The new targeted modifications undoubtedly provide a prospect improving current treatments.

Language: Английский

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Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(3), P. 457 - 457

Published: Jan. 28, 2022

In the last few decades, vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that can offer solutions to current challenges raw materials in fields. This review describes different nanoparticles nanostructured material synthesis approaches presents some emerging biomedical, healthcare, agro-food applications. focuses on various nanomaterial types (e.g., spherical, nanorods, nanotubes, nanosheets, nanofibers, core-shell, mesoporous) be synthesized from their bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, agro-foods. Depending morphology size, aspect ratio, geometry, porosity), used as formulation modifiers, moisturizers, nanofillers, additives, membranes, films. As toxicological assessment depends sizes morphologies, stringent regulation is needed testing efficient dosages. The perspectives an industrial breakthrough are related optimization production processing conditions.

Language: Английский

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Recent advances in nanomaterial-based synergistic combination cancer immunotherapy

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(14), P. 3771 - 3810

Published: Jan. 1, 2019

This review aims to summarize various synergistic combination cancer immunotherapy strategies based on nanomaterials.

Language: Английский

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Gene Therapy Leaves a Vicious Cycle

Frontiers in Oncology, Journal Year: 2019, Volume and Issue: 9

Published: April 24, 2019

The human genetic code is the vehicle that drives synthesis of proteins necessary for life-sustaining biological processes. Though ciphering remains unchanged through generations, some genes get disrupted, deleted and/or mutated, manifested as diseases and disorders. Current treatment options—chemotherapy, protein therapy, radiotherapy, surgery available less than 500 diseases—neither cure nor prevent errors, but rather, often cause many side effects. However, gene colloquially called "living drug," provides a one-time option by rewriting or fixing errors in natural ciphering. Since therapy predominantly viral vector-based medicine, it has met with fair bit skepticism from both science fraternity patients. Now, thanks to advancements editing recombinant vector development, interest clinicians pharmaceutical industries been rekindled. With advent more 12 different drugs curing cancer, blindness, immune, neuronal disorders, this emerging experimental medical yet again come limelight. present review article delves into popular vectors used advances, challenges, perspectives.

Language: Английский

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Peptide-Based Supramolecular Systems Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13869 - 13914

Published: Sept. 14, 2021

Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms use conserved sets building blocks and chemical reactions achieve a bewildering array functions. Building on design principles for short peptide-based nanomaterials with properties, such as self-assembly, recognition, catalysis, actuation, are increasingly available. is starting address far greater challenge systems-level access complex functions that emerge when multiple interactions coordinated integrated. We discuss key features relevant design, including regulating order disorder, development active adaptive by considering kinetic thermodynamic aspects combinatorial dynamic covalent noncovalent interactions. Finally, we how structural concepts, preorganization induced fit, critical develop materials tunable photonic, electronic, catalytic properties. highlight examples where combined, resulting in display properties cannot be achieved without this level integration.

Language: Английский

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Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 420, P. 213410 - 213410

Published: June 18, 2020

Language: Английский

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Rational Design of Nanocarriers for Intracellular Protein Delivery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(46)

Published: Sept. 8, 2019

Abstract Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, poor penetration membrane, thus clinical use protein drugs is hindered inefficient delivery proteins into host cells. To overcome challenges associated with enhance their biopharmaceutical applications, various protein‐loaded nanocarriers desired functions, lipid nanocapsules, polymeric nanoparticles, inorganic peptides, developed. In this review, different strategies for intracellular comprehensively summarized. Their designed routes, mechanisms action, potential in live cells or vivo discussed detail. Furthermore, perspective on new generation systems toward emerging area protein‐based presented well.

Language: Английский

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Enhanced Chemodynamic Therapy by Cu–Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2535 - 2545

Published: Jan. 26, 2022

An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion the reaction increases risk damaging normal cells along with cancer cells. Therefore, a tailored strategy selectively enhance reactivity tumors, for example, by taking advantage characteristics tumor microenvironment (TME), demand. Herein, heterogeneous system based on copper–iron peroxide nanoparticles (CFp NPs) designed TME-mediated synergistic therapy. CFp NPs degrade under mildly acidic conditions TME, self-supply H2O2, and released Cu Fe ions, their larger portions lower oxidation states, cooperatively facilitate hydroxyl radical production through highly efficient loop an excellent therapeutic efficacy. This distinct from previous systems that synergism closely coupled Cu+-assisted conversion Fe3+ Fe2+ rather than independent actions. As result, almost complete ablation tumors minimal treatment dose demonstrated without aid any other modality. Furthermore, generate O2 during catalysis exhibit TME-responsive T1 magnetic resonance imaging contrast enhancement, which are useful alleviating hypoxia vivo monitoring respectively.

Language: Английский

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