Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(18)

Published: Dec. 3, 2019

Bacterial infection is one of the top ten leading causes death globally and worst killer in low-income countries. The overuse antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat human health. Recent advances nanotechnology provide new opportunities address challenges bacterial by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled advanced nanomaterials are presented. Nanomaterials classified on basis their mode action: with intrinsic or light-mediated bactericidal properties others that serve as vehicles for delivery natural compounds. Specific attention given mechanisms structure-performance relationship. Practical applications employing these antibiotic-free also introduced. Current this field future perspectives presented stimulate technologies translation fight against infection.

Language: Английский

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Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 3546 - 3562

Published: Feb. 18, 2020

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present all-in-one phototherapeutic nanoplatform consisting l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate already-formed The fabrication process included surface modification MPDA with l-Arg further adsorption ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing cascade catalysis release nitric oxide (NO). NIR irradiation, biofilm elimination was attributed NO-enhanced photodynamic therapy low-temperature PTT (≤45 °C). Notably, NIR-triggered strategy resulted in severe destruction bacterial membranes. displayed good cytocompatibility. NIR-irradiated nanoparticles prevented colonization realized rapid recovery infected wounds. More importantly, platform effective efficiency around 100% abscess formation model. Overall, this provides reliable tool biofilms clinical applications.

Language: Английский

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Nanoparticle–Biofilm Interactions: The Role of the EPS Matrix

Trends in Microbiology, Journal Year: 2019, Volume and Issue: 27(11), P. 915 - 926

Published: Aug. 13, 2019

Language: Английский

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Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms

ACS Nano, Journal Year: 2019, Volume and Issue: 14(1), P. 347 - 359

Published: Dec. 30, 2019

Biofilm has resulted in numerous obstinate clinical infections, posing severe threats to public health. It is urgent develop original antibacterial strategies for eradicating biofilms. Herein, we a surface charge switchable supramolecular nanocarrier exhibiting pH-responsive penetration into an acidic biofilm nitric oxide (NO) synergistic photodynamic eradication of the methicillin-resistant Staphylococcus aureus (MRSA) with negligible damage healthy tissues under laser irradiation. Originally, by integrating glutathione (GSH)-sensitive α-cyclodextrin (α-CD) conjugated prodrug (α-CD-NO) and chlorin e6 (Ce6) (α-CD-Ce6) pH-sensitive poly(ethylene glycol) (PEG) block polypeptide copolymer (PEG-(KLAKLAK)2-DA) via host–guest interaction, α-CD-Ce6-NO-DA was finely prepared. The shows complete reversal from negative at physiological pH (7.4) positive (5.5), promoting efficient biofilm. Once infiltrated biofilm, exhibits rapid NO release triggered overexpressed GSH which not only produces abundant killing bacteria but also reduces level improve therapy (PDT) efficiency. On other hand, can react reactive oxygen species (ROS) produce nitrogen (RNS), further improving PDT Due effective depletion GSH, GSH-sensitive greatly efficiency low photosensitizer dose intensity cause side effect tissues. Considering above advantages, strategy developed this work may offer great possibilities fight against infections.

Language: Английский

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Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application

ACS Nano, Journal Year: 2019, Volume and Issue: 13(6), P. 6770 - 6781

Published: May 28, 2019

The abuse of traditional antibiotics has caused a series health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) flavonoid glycosides: nanoparticles (NPs) nanofibers (NFs), were both mainly governed by electrostatic hydrophobic interactions. These nanostructures exhibited different antibacterial properties from BBR. NPs showed significantly enhanced bacteriostatic activity, whereas NFs displayed much weaker effect than distinguishing can be attributed the spatial configurations self-assembly processes NFs. Flavonoid glycosides BBR first formed one-dimensional complex unit subsequently self-assembled into three-dimensional nanostructures. With hydrophilic glucuronic acid toward outside, stronger affinity bacteria, thereby inducing collapse bacteria population decrease in biofilm. In addition, vitro hemolysis tests, cytotoxicity vivo zebrafish toxicity evaluation that obtained self-assemblies had good biocompatibility. This supramolecular strategy applied construct other nanoscale drugs thus provides weapons development self-delivering infection treatment.

Language: Английский

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Synthesis, Applications, and Prospects of Graphene Quantum Dots: A Comprehensive Review

Small, Journal Year: 2021, Volume and Issue: 18(2)

Published: Sept. 22, 2021

Abstract Graphene quantum dot (GQD) is one of the youngest superstars carbon family. Since its emergence in 2008, GQD has attracted a great deal attention due to unique optoelectrical properties. Non‐zero bandgap, ability accommodate functional groups and dopants, excellent dispersibility, highly tunable properties, biocompatibility are among most important characteristics GQDs. To date, GQDs have displayed significant momentum numerous fields such as energy devices, catalysis, sensing, photodynamic photothermal therapy, drug delivery, bioimaging. As this field rapidly evolving, there strong need identify emerging challenges recent advances, mainly because some novel applications innovations on ease synthesis not systematically reviewed earlier studies. This feature article provides comparative balanced discussion advances synthesis, Besides, current future prospects these carbon‐based nanomaterials also highlighted. The outlook provided review points out that research boundless, particularly if upcoming studies focus purification eco‐friendly along with improving photoluminescence yield production

Language: Английский

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Antimicrobial Metal Nanomaterials: From Passive to Stimuli‐Activated Applications

Advanced Science, Journal Year: 2020, Volume and Issue: 7(10)

Published: April 6, 2020

The development of antimicrobial drug resistance among pathogenic bacteria and fungi is one the most significant health issues 21st century. Recently, advances in nanotechnology have led to nanomaterials, particularly metals that exhibit properties. These metal nanomaterials emerged as promising alternatives traditional therapies. In this review, a broad overview their synthesis, properties, interactions with micro-organisms first provided. Secondly, range demonstrate passive properties are outlined in-depth analysis comparison stimuli-responsive provided, which represent next generation microbiocidal nanomaterials. stimulus applied activate such includes light (including photocatalytic photothermal) magnetic fields, can induce hyperthermia kinetically driven activation. Broadly, review aims summarize currently available research provide future scope for nanomaterial-based technologies, those be activated through externally stimuli.

Language: Английский

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Advanced bioactive nanomaterials for biomedical applications

Exploration, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Language: Английский

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Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management

ACS Nano, Journal Year: 2020, Volume and Issue: 14(5), P. 5686 - 5699

Published: April 22, 2020

Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem, which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great potential in treatment biofilms, efficient penetration and retention still a big challenge. To address this issue, we herein fabricate size charge adaptive azithromycin (AZM)-conjugated clustered (denoted as AZM-DA NPs) therapeutic agents for treating biofilms. The NPs are prepared electrostatic complexation between AZM conjugated amino-ended poly(amidoamine) dendrimer (PAMAM) 2,3-dimethyl maleic anhydride (DA) modified poly(ethylene glycol)-block-polylysine (PEG-b-PLys). It noteworthy that disassemble acidic biofilm microenvironment (pH 6.0), leading release secondary AZM-conjugated PAMAM (PAMAM-AZM NPs). PAMAM-AZM with small positive beneficial improved inside enhanced permeabilization membrane, increased internalization AZM, thus exhibiting excellent antibiofilm activities. also favorable long-term antibacterial due reduced occurrence drug resistance. In vivo performance confirmed burden alleviated inflammation chronic model. This research not only develops innovative strategy delivery but provides effective way management biofilm-associated infections, including infection.

Language: Английский

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Anti-biofilm and Antibacterial Activities of Silver Nanoparticles Synthesized by the Reducing Activity of Phytoconstituents Present in the Indian Medicinal Plants

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: June 23, 2020

Biofilm forming from a variety of microbial pathogens can pose serious health hazard that is difficult to combat. Nanotechnology, however, represents new approach fighting and eradicating biofilm-forming microorganisms. In the present study, sustainable synthesis characterization biocompatible silver nanoparticles (AgNPs) leaf extracts Semecarpus anacardium, Glochidion lanceolarium, Bridelia retusa was explored. Continuous observed in UV-vis spectroscopic analysis participating phytoconstituents, flavonoids, phenolic compounds, phytosterols, glycosides, were characterized by Attenuated total reflectance-Fourier transform infrared spectroscopy. The size surface charge particles also measured dynamic light scattering Scanning electron microscopy study employed examine morphology nanoparticles. microscopic confirmed successful AgNPs plant acting as strong reducing agents. synthesized screened for antibacterial anti-biofilm activity against human Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus. Results demonstrate potential phyto-synthesized act agents other biomedical applications.

Language: Английский

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