Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(12)

Published: Feb. 9, 2021

Abstract The rapid knowledge growth of nanomedicine and nanobiotechnology enables promotes the emergence distinctive disease‐specific therapeutic modalities, among which nanomedicine‐enabled/augmented nanodynamic therapy (NDT), as triggered by either exogenous or endogenous activators on nanosensitizers, can generate reactive radicals for accomplishing efficient disease nanotherapies with mitigated side effects endowed specificity. As one most representative modalities NDT, traditional light‐activated photodynamics suffers from critical unsurmountable issues low tissue‐penetration depth light phototoxicity photosensitizers. To overcome these obstacles, versatile NDTs have been explored satisfying varied biomedical applications, strongly depend physicochemical properties involved nanomedicines nanosensitizers. These refer to sonodynamic (SDT), thermodynamic (TDT), electrodynamic (EDT), piezoelectric dynamic (PZDT), pyroelectric (PEDT), radiodynamic (RDT), chemodynamic (CDT). Herein, roles, functions, biological (e.g., sonosensitizing, photothermal‐converting, electronic, piezoelectric, pyroelectric, radiation‐sensitizing, catalytic properties) enabling procedure NDTs, are highlighted discussed, along underlying principle optimization strategy augmenting disease‐therapeutic efficacy biosafety. present challenges clinical translations also discussed clarified.

Language: Английский

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A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(7)

Published: Jan. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Language: Английский

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Engineering Radiosensitizer‐Based Metal‐Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(10)

Published: Dec. 29, 2021

Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization immunomodulation may overcome these obstacles for advanced radiotherapy. Here, authors propose cooperated with stimulator interferon genes (STING) pathway activation strategy fabricating novel lanthanide-doped radiosensitizer-based metal-phenolic network, NaGdF4 :Nd@NaLuF4 @PEG-polyphenol/Mn (DSPM). amphiphilic PEG-polyphenol successfully coordinates (radiosensitizer) Mn2+ via robust coordination. After cell internalization, pH-responsive disassembly DSPM triggers release their payloads, wherein radiosensitizer sensitizes cells to X-ray promote STING activation. This remarkably benefits dendritic maturation, anticancer therapeutics in primary tumors, accompanied immune therapeutic performance against metastatic tumors. Therefore, powerful mediated immunostimulation is highlighted here optimize

Language: Английский

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Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications

Theranostics, Journal Year: 2020, Volume and Issue: 10(3), P. 1296 - 1318

Published: Jan. 1, 2020

Photodynamic therapy (PDT) has shown great effectiveness in oncotherapy but not been implemented broad clinical applications because the limited penetration depth of light used unable to reach deep-seated tumors. However, X-rays have widely field for imaging and radiation due their excellent tissue depth. Recently, established as an ideal excitation source PDT, which holds promise breaking limitation traditional PDT treatment This review aims provide overview nanoscintillator-mediated X-ray induced (X-PDT) including concept, design considerations nanosensitizers X-PDT, modelling nanosensitizer energy deposition, putative mechanism by X-PDT kills cells, prospects future directions. We attempt summarize main developments that occurred over past decades. Possibilities challenges translation are also discussed.

Language: Английский

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Recent Development in X-Ray Imaging Technology: Future and Challenges

Research, Journal Year: 2021, Volume and Issue: 2021

Published: Jan. 1, 2021

X-ray imaging is a low-cost, powerful technology that has been extensively used in medical diagnosis and industrial nondestructive inspection. The ability of X-rays to penetrate through the body presents great advances for noninvasive its internal structure. In particular, technological importance led rapid development high-performance detectors associated applications. Here, we present an overview recent imaging-related technologies since discovery 1890s discuss fundamental mechanism diverse instruments, as well their advantages disadvantages on performance. We also highlight various applications advanced diversity fields. further future research directions challenges developing next-generation materials are crucial fabrication flexible, low-dose, high-resolution detectors.

Language: Английский

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High energy X-ray radiation sensitive scintillating materials for medical imaging, cancer diagnosis and therapy

Nano Energy, Journal Year: 2020, Volume and Issue: 79, P. 105437 - 105437

Published: Oct. 2, 2020

Language: Английский

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Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Cancers, Journal Year: 2021, Volume and Issue: 13(14), P. 3484 - 3484

Published: July 13, 2021

Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some the main beneficial features PDT. Despite great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, complicated implementations clinic limiting factors hindering extended use To surpass actual technological paradigms, radically new sources, light-based devices, advanced measurement innovative strategies under extensive investigation. The aim this review to highlight advantages/pitfalls, technical challenges opportunities PDT, focus on technologies for activation such as delivery systems. In vein, broad overview current status superficial, interstitial, deep PDT modalities-and critical sources their effects process-are presented. Insight into advancements remaining optical devices provided from physical bioengineering perspective.

Language: Английский

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Application of Radiosensitizers in Cancer Radiotherapy

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 1083 - 1102

Published: Feb. 1, 2021

Abstract: Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cells and shrink tumors. Although great success has been achieved on radiotherapy, there still an intractable challenge enhance damage tumor tissue reduce side effects healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents can the killing effect by accelerating DNA producing free radicals indirectly. In most cases, radiosensitizers have less normal tissues. recent years, several strategies exploited develop highly effective low toxicity. this review, we first summarized applications including small molecules, macromolecules, nanomaterials, especially those used in clinical trials. Second, development states possible mechanisms improve sensibility reviewed. Third, challenges prospects for translation oncotherapy presented. Keywords: radiosensitizers, therapeutics, nanomedicine, mechanism Corrigendum paper published

Language: Английский

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Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 30, 2022

Abstract X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of and radiotherapy. Conventional usually requires heavy-metal-containing inorganic scintillators organic photosensitizers generate singlet oxygen. Here, we report a more convenient strategy based on class phosphorescence nanoscintillators, that act dual capacity as photosensitizers. The resulting low dose 0.4 Gy negligible adverse effects demonstrate great potential treatment tumours. These findings provide an optional route leverages optical properties purely deep-tissue therapy. Furthermore, these nanoscintillators offer opportunity expand applications fields biomaterials nanobiotechnology.

Language: Английский

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Multi-Label Active Learning-Based Machine Learning Model for Heart Disease Prediction

Sensors, Journal Year: 2022, Volume and Issue: 22(3), P. 1184 - 1184

Published: Feb. 4, 2022

The rapid growth and adaptation of medical information to identify significant health trends help with timely preventive care have been recent hallmarks the modern healthcare data system. Heart disease is deadliest condition in developed world. Cardiovascular its complications, including dementia, can be averted early detection. Further research this area needed prevent strokes heart attacks. An optimal machine learning model achieve goal a wealth on disease. predicted diagnosed using machine-learning-based systems. Active (AL) methods improve classification quality by incorporating user-expert feedback sparsely labelled data. In paper, five (MMC, Random, Adaptive, QUIRE, AUDI) selection strategies for multi-label active were applied used reducing labelling costs iteratively selecting most relevant query their labels. label ranking classifier hyperparameters optimized grid search implement predictive modelling each scenario dataset. Experimental evaluation includes accuracy F-score with/without hyperparameter optimization. Results show that generalization beyond existing uses method versus others due accuracy. However, was highlighted regards settings.

Language: Английский

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