Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121645 - 121645

Published: June 22, 2022

Language: Английский

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Rational Design of Platinum–Bismuth Sulfide Schottky Heterostructure for Sonocatalysis‐Mediated Hydrogen Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(10)

Published: Dec. 18, 2022

Conventional sonodynamic therapy is unavoidably limited by the tumor microenvironment, although many sonosensitizers have been developed to improve them a certain extent. Given this, concept of sonocatalytic hydrogen evolution proposed, which defined as an oxygen-independent therapeutics. To demonstrate feasibility concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ) selected sonocatalyst and platinum (Pt) nanoparticles are grown in situ optimize their catalytic performance. In this nanocatalytic system, Pt help capture sonoexcited electrons, whereas intratumoral overexpressed glutathione (GSH), natural hole sacrificial agent, can consume holes, greatly improves charge-separation efficiency promotes controllable sustainable H2 generation. Even under hypoxic conditions, Pt-Bi2 also produce sufficient ultrasound irradiation. Mechanistically, mitochondrial dysfunction caused redox homeostasis destruction GSH depletion synergistically damage DNA induce cells apoptosis. At same time, holes trigger decomposition peroxide into O2 relieve hypoxia, thus being synergistic with reverse immunosuppressive microenvironment. The proposed sonocatalysis-mediated will provide new direction realize facile efficient cancer therapy.

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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Nanomaterials-based photosensitizers and delivery systems for photodynamic cancer therapy

Biomaterials Advances, Journal Year: 2022, Volume and Issue: 135, P. 212725 - 212725

Published: April 1, 2022

Language: Английский

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