International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7473 - 7473
Published: April 18, 2023
Antibiotic
resistance
is
one
of
the
greatest
threats
to
global
health
and
food
security
today.
It
becomes
increasingly
difficult
treat
infectious
disorders
because
antibiotics,
even
newest
ones,
are
becoming
less
effective.
One
ways
taken
in
Global
Plan
Action
announced
at
World
Health
Assembly
May
2015
ensure
prevention
treatment
diseases.
In
order
do
so,
attempts
made
develop
new
antimicrobial
therapeutics,
including
biomaterials
with
antibacterial
activity,
such
as
polycationic
polymers,
polypeptides,
polymeric
systems,
provide
non-antibiotic
therapeutic
agents,
selected
biologically
active
nanoparticles
chemical
compounds.
Another
key
issue
preventing
from
contamination
by
developing
packaging
materials,
particularly
based
on
degradable
polymers
biocomposites.
This
review,
a
cross-sectional
way,
describes
most
significant
research
activities
conducted
recent
years
field
development
materials
polymer
composites
properties.
We
focus
natural
i.e.,
polysaccharides
which
present
mechanism
for
combating
many
highly
pathogenic
microorganisms.
also
attempt
use
this
knowledge
obtain
synthetic
similar
activity.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(8), P. 4932 - 4973
Published: Jan. 1, 2021
Antimicrobial
resistance
(AMR)
is
one
of
the
greatest
threats
to
human
health
that,
by
2050,
will
lead
more
deaths
from
bacterial
infections
than
cancer.
New
antimicrobial
agents,
both
broad-spectrum
and
selective,
that
do
not
induce
AMR
are
urgently
required.
peptides
(AMPs)
a
novel
class
alternatives
possess
potent
activity
against
wide
range
Gram-negative
positive
bacteria
with
little
or
no
capacity
AMR.
This
has
stimulated
substantial
chemical
development
peptide-based
antibiotics
possessing
improved
therapeutic
index.
review
summarises
recent
synthetic
efforts
their
impact
on
analogue
design
as
well
various
applications
in
AMP
development.
It
includes
modifications
have
been
reported
enhance
including
lipidation,
glycosylation
multimerization
through
broad
application
bio-orthogonal
chemistry,
perspectives
direction
future
research.
The
subject
area
primarily
next-generation
agents
rational
modification
AMPs.
further
serves
guide
toward
most
promising
directions
this
field
stimulate
scientific
attention,
new,
effective
selective
solutions
for
several
biomedical
challenges
which
peptidomimetics
being
applied.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(13), P. 7820 - 7880
Published: Jan. 1, 2021
This
review
discusses
the
diversity
of
structure
and
physicochemical
properties
antimicrobial
peptides
their
derivatives,
various
chemical
synthetic
strategies
that
have
been
applied
in
development,
how
this
links
to
activity.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(22), P. 13915 - 13935
Published: Oct. 28, 2021
Peptides
have
been
extensively
utilized
to
construct
nanomaterials
that
display
targeted
structure
through
hierarchical
assembly.
The
self-assembly
of
both
rationally
designed
peptides
derived
from
naturally
occurring
domains
in
proteins
as
well
intuitively
or
computationally
form
β-sheets
and
helical
secondary
structures
widely
successful
constructing
nanoscale
morphologies
with
well-defined
1-d,
2-d,
3-d
architectures.
In
this
review,
we
discuss
these
successes
peptide
self-assembly,
especially
the
context
designing
materials.
particular,
emphasize
differences
level
design
an
indicator
complexity
within
self-assembled
materials
highlight
future
avenues
for
scientific
technological
advances
field.
Biomacromolecules,
Journal Year:
2022,
Volume and Issue:
23(5), P. 1841 - 1863
Published: April 19, 2022
Synthetic
polymers
have
been
an
integral
part
of
modern
society
since
the
early
1960s.
Besides
their
most
well-known
applications
to
public,
such
as
packaging,
construction,
textiles
and
electronics,
synthetic
also
revolutionized
field
medicine.
Starting
with
first
plastic
syringe
developed
in
1955
complex
polymeric
materials
used
regeneration
tissues,
contributions
never
more
prominent.
Decades
research
on
materials,
stem
cells,
three-dimensional
printing
contributed
rapid
progress
tissue
engineering
regenerative
medicine
that
envisages
potential
future
organ
transplantations.
This
perspective
discusses
role
engineering,
design
properties
relation
each
type
application.
Additionally,
selected
recent
achievements
using
are
outlined
provide
insight
into
how
they
will
contribute
advancement
near
future.
In
this
way,
we
aim
a
guide
help
scientists
polymer
selection
for
different
applications.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 10, 2022
Abstract
Surface
charge
of
biological
and
medical
nanocarriers
has
been
demonstrated
to
play
an
important
role
in
cellular
uptake.
Owing
the
unique
physicochemical
properties,
charge-reversal
delivery
strategy
rapidly
developed
as
a
promising
approach
for
drug
application,
especially
cancer
treatment.
Charge-reversal
are
neutral/negatively
charged
at
physiological
conditions
while
could
be
triggered
positively
by
specific
stimuli
(i.e.,
pH,
redox,
ROS,
enzyme,
light
or
temperature)
achieve
prolonged
blood
circulation
enhanced
tumor
uptake,
thus
potentiate
antitumor
effects
delivered
therapeutic
agents.
In
this
review,
we
comprehensively
summarized
recent
advances
nanocarriers,
including:
(i)
effect
surface
on
uptake;
(ii)
charge-conversion
mechanisms
responding
several
stimuli;
(iii)
relation
between
chemical
structure
reversal
activity;
(iv)
polymeric
materials
that
commonly
applied
systems.
Graphical
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(5), P. 636 - 636
Published: April 25, 2022
Poly(α-L-glutamic
acid)
(PGA)
is
a
class
of
synthetic
polypeptides
composed
the
monomeric
unit
α-L-glutamic
acid.
Owing
to
their
biocompatibility,
biodegradability,
and
non-immunogenicity,
PGA-based
nanomaterials
have
been
elaborately
designed
for
drug
delivery
systems.
Relevant
studies
including
latest
research
results
on
discussed
in
this
work.
The
following
related
topics
are
summarized
as:
(1)
brief
description
strategies
PGAs;
(2)
an
elaborated
presentation
evolving
applications
PGA
areas
delivery,
rational
design,
precise
fabrication,
biological
evaluation;
(3)
profound
discussion
further
development
delivery.
In
summary,
unique
structures
superior
properties
enables
represent
as
enormous
potential
biomaterials-related
areas.
ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(2), P. 366 - 393
Published: Jan. 24, 2022
Bacterial
resistance
caused
by
the
overuse
of
antibiotics
and
shelter
biofilms
has
evolved
into
a
global
health
crisis,
which
drives
researchers
to
continuously
explore
antimicrobial
molecules
strategies
fight
against
drug-resistant
bacteria
biofilm-associated
infections.
Cationic
peptides
(AMPs)
are
considered
be
category
potential
alternative
for
owing
their
excellent
bactericidal
potency
lesser
likelihood
inducing
drug
through
distinctive
mechanisms.
In
this
review,
hitherto
reported
plentiful
action
modes
AMPs
systematically
classified
15
types
three
categories
(membrane
destructive,
nondestructive
membrane
disturbance,
intracellular
targeting
mechanisms).
Besides
natural
AMPs,
cationic
polypeptides,
synthetic
polymers,
biopolymers
enable
achieve
tunable
properties
optimizing
structures.
Subsequently,
applications
these
agents
at
biointerface
as
contact-active
surface
coatings
multifunctional
wound
dressings
also
emphasized
here.
At
last,
we
provide
our
perspectives
on
development
clinically
significant
antimicrobials
related
challenges
in
translation
materials.
Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Oct. 9, 2023
Abstract
Polysaccharides
are
a
class
of
natural
biopolymers
that
have
attracted
significant
attention
due
to
their
unique
properties,
which
make
them
attractive
for
use
in
wide
range
applications.
These
an
important
role
our
daily
life,
and
designing
biomaterials
biomedical
applications
requires
careful
consideration
factors
such
as
biocompatibility,
biodegradability,
renewability,
affordability,
availability,
all
can
be
achieved
with
polysaccharides.
This
review
paper
focuses
on
the
polysaccharides
provides
in‐depth
analysis
potential
arabinoxylan,
type
hemicellulose,
various
fields,
including
drug
delivery,
infection
control,
tissue
engineering,
wound
healing,
others.
Arabinoxylan,
is
derived
from
plants,
most
abundant
hemicellulose
has
diverse
catalyst
its
renewable
nature.
Polysaccharide‐based
covers,
delivery
systems,
food
preservation,
biocomposite
films,
making
emerging
excipient
pharmaceutical
research.
highlights
polysaccharide‐based
science
suggests
continued
research
development
will
lead
broader
more
innovative
field.
The
significantly
advance
healthcare
improve
patient
outcomes.
