Molecules,
Journal Year:
2021,
Volume and Issue:
26(10), P. 2937 - 2937
Published: May 14, 2021
Natural
peptides
are
an
important
class
of
chemical
mediators,
essential
for
most
vital
processes.
What
limits
the
potential
use
as
drugs
is
their
low
bioavailability
and
enzymatic
degradation
in
vivo.
To
overcome
this
limitation,
development
new
molecules
mimicking
great
importance
biologically
active
molecules.
Therefore,
replacing
amide
bond
a
peptide
with
heterocyclic
bioisostere,
such
1,2,3-triazole
ring,
can
be
considered
effective
solution
synthesis
relevant
peptidomimetics.
These
1,2,3-triazoles
may
have
interesting
biological
activity,
because
they
behave
rigid
link
units,
which
mimic
electronic
properties
bonds
show
bioisosteric
effects.
Additionally,
triazole
used
linker
moiety
to
other
functional
groups.
Military Medical Research,
Journal Year:
2021,
Volume and Issue:
8(1)
Published: Sept. 9, 2021
Abstract
The
management
of
bacterial
infections
is
becoming
a
major
clinical
challenge
due
to
the
rapid
evolution
antibiotic
resistant
bacteria.
As
an
excellent
candidate
overcome
resistance,
antimicrobial
peptides
(AMPs)
that
are
produced
from
synthetic
and
natural
sources
demonstrate
broad-spectrum
activity
with
high
specificity
low
toxicity.
These
possess
distinctive
structures
functions
by
employing
sophisticated
mechanisms
action.
This
comprehensive
review
provides
broad
overview
AMPs
origin,
structural
characteristics,
action,
biological
activities
applications.
We
finally
discuss
strategies
optimize
develop
AMP-based
treatment
as
potential
anticancer
therapeutics.
Medicinal Research Reviews,
Journal Year:
2022,
Volume and Issue:
42(4), P. 1377 - 1422
Published: Jan. 4, 2022
Antimicrobial
peptides
(AMPs),
also
known
as
host
defense
(HDPs),
are
important
effector
immune
molecules
in
multicellular
organisms.
AMPs
exert
their
antimicrobial
activities
through
several
mechanisms;
thus
far,
induction
of
drug
resistance
has
been
regarded
unlikely.
Therefore,
they
have
great
potential
new
generation
agents.
To
date,
more
than
30
AMP-related
drugs
the
clinical
trial
phase.
In
recent
years,
studies
show
that
some
and
conventional
antibiotics
synergistic
effects.
The
combined
use
can
kill
drug-resistant
pathogens,
prevent
resistance,
significantly
improve
therapeutic
effects
antibiotics.
this
review,
we
discuss
progress
on
An
overview
current
understanding
functional
scope
AMPs,
ongoing
trials,
challenges
development
processes
presented.
Nucleic Acids Research,
Journal Year:
2021,
Volume and Issue:
50(D1), P. D460 - D470
Published: Oct. 25, 2021
The
last
18
months,
or
more,
have
seen
a
profound
shift
in
our
global
experience,
with
many
of
us
navigating
once-in-100-year
pandemic.
To
date,
COVID-19
remains
life-threatening
pandemic
little
to
no
targeted
therapeutic
recourse.
discovery
novel
antiviral
agents,
such
as
vaccines
and
drugs,
can
provide
solutions
save
human
beings
from
severe
infections;
however,
there
is
specifically
effective
treatment
confirmed
for
now.
Thus,
great
attention
has
been
paid
the
use
natural
artificial
antimicrobial
peptides
(AMPs)
these
compounds
are
widely
regarded
promising
harmful
microorganisms.
Given
biological
significance
AMPs,
it
was
obvious
that
significant
need
single
platform
identifying
engaging
AMP
data.
This
led
creation
dbAMP
provides
comprehensive
information
about
AMPs
facilitates
their
investigation
analysis.
accumulated
26
447
2262
proteins
3044
organisms
using
both
database
integration
manual
curation
>4579
articles.
In
addition,
evaluation
structures
I-TASSER
automated
protein
structure
prediction
structure-based
functional
annotation,
providing
predictive
clinical
drug
development.
Next-generation
sequencing
(NGS)
third-generation
applied
generate
large-scale
reads
various
environments,
enabling
greatly
improved
analysis
genome
structure.
this
update,
we
launch
an
efficient
online
tool
effectively
identify
genome/metagenome
proteome
data
all
species
short
period.
conclusion,
improvements
promote
one
most
abundant
comprehensively
annotated
resources
AMPs.
updated
now
freely
accessible
at
http://awi.cuhk.edu.cn/dbAMP.
Burns & Trauma,
Journal Year:
2022,
Volume and Issue:
10
Published: Jan. 1, 2022
Abstract
Acute
and
chronic
wound
infection
has
become
a
major
worldwide
healthcare
burden
leading
to
significantly
high
morbidity
mortality.
The
underlying
mechanism
of
infections
been
widely
investigated
by
scientist,
while
standard
management
is
routinely
used
in
general
practice.
However,
strategies
for
the
diagnosis
treatment
remain
great
challenge
due
occurrence
biofilm
colonization,
delayed
healing
drug
resistance.
In
present
review,
we
summarize
common
microorganisms
found
acute
discuss
challenges
from
aspects
clinical
diagnosis,
non-surgical
methods
surgical
methods.
Moreover,
highlight
emerging
innovations
development
antimicrobial
peptides,
phages,
controlled
delivery,
dressing
materials
herbal
medicine,
find
that
sensitive
diagnostics,
combined
skin
microbiome
regulation
could
be
future
directions
infection.
Results in Engineering,
Journal Year:
2022,
Volume and Issue:
16, P. 100671 - 100671
Published: Sept. 28, 2022
Hospitals
played
vital
role
in
the
maintenance
and
sustenance
of
human
health.
However,
hospital
activities
generate
high
volume
toxic
solid
liquid
containing
diverse
inorganic,
organic
microbial
wastes
released
untreated
into
ecosystem.
The
management
wastewater
particular
has
been
a
major
source
concern
due
to
presence
unregulated
emerging
micro-pollutants
at
concentrations
range
ng/L
μg/L.
These
pollutants
low
concentration
exert
different
potential
health
effects
on
aquatic
species.
In
this
review,
formation,
composition,
properties
ecotoxicology
selected
(Norfloxacin,
Ofloxacin,
Ciprofloxacin,
Clofibric
acid
Carbamazepine)
were
reviewed.
review
also
elucidates
detection
quantification
micropollutants
by
Spectrophotometry
techniques,
Gas
Chromatography,
Ion
Chromatography-Mass
spectrometry,
High-Performance
Liquid
Chromatography.
Furthermore,
treatment
through
physical,
biological,
chemical,
adsorption
advanced
oxidation
processes
such
as
photocatalysis
photo-Fenton
including
their
operational
mechanism
provided.
chemistry
degradation
several
intermediates
It
was
found
that
conventional
methods
are
not
designed
for
effective
removal
these
because
they
exist
mixtures
very
exerts
toxicological
effects.
reveals
no
single
technology
can
effectively
detoxify
wastewater,
instead
combination
(phototcatalytic/adsorption
or
photo-fenton/adsorption)
most
appropriate
treatment.
Finally,
regular
monitoring
determination
physicochemical
ecotoxicological
parameters
recommended.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(14), P. 2384 - 2429
Published: Jan. 1, 2022
The
design
of
antimicrobial
peptide-based
materials
for
biomedical
applications
such
as
fighting
infections
in
various
organs,
cancer
therapy,
gene
delivery
and
detection
bacteria.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(3), P. 642 - 642
Published: March 15, 2022
Bacterial
resistance
is
an
emergency
public
health
problem
worldwide,
compounded
by
the
ability
of
bacteria
to
form
biofilms,
mainly
in
seriously
ill
hospitalized
patients.
The
World
Health
Organization
has
published
a
list
priority
that
should
be
studied
and,
turn,
encouraged
development
new
drugs.
Herein,
we
explain
importance
studying
molecules
such
as
antimicrobial
peptides
(AMPs)
with
potential
against
multi-drug
resistant
(MDR)
and
extensively
drug-resistant
(XDR)
focus
on
inhibition
biofilm
formation.
This
review
describes
main
causes
formation,
well
AMP
applications
these
bacteria.
Our
results
suggest
biomacromolecules
discovered
this
group
dangerous
highly
infectious
Alternative
AMPs
could
contribute
eradicating
proliferation
MDR/XDR
bacteria;
challenging
undertaking
promising
prospects.
