Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 7078 - 7093

Published: March 25, 2021

The design and development of a smart bioadhesive hydrogel sealant with self-healing excellent antibacterial activity to achieve high wound closure effectiveness post-wound-closure care is highly desirable in clinical applications. In this work, series adhesive antioxidant hydrogels promising traits were designed through dual-dynamic-bond cross-linking among ferric iron (Fe), protocatechualdehyde (PA) containing catechol aldehyde groups quaternized chitosan (QCS) enable the skin incisions promotion methicillin-resistant Staphylococcus aureus (MRSA)-infected healing. pH-sensitive coordinate bond (catechol–Fe) dynamic Schiff base bonds reversible breakage re-formation equips autonomous healing on-demand dissolution or removal properties. Additionally, presents injectability, good biocompatibility activity, multifunctional adhesiveness, hemostasis as well NIR responsiveness. vivo evaluation rat incision model infected full-thickness revealed hydrogels, demonstrating its great potential dealing wounds.

Language: Английский

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Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(18)

Published: Dec. 3, 2019

Bacterial infection is one of the top ten leading causes death globally and worst killer in low-income countries. The overuse antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat human health. Recent advances nanotechnology provide new opportunities address challenges bacterial by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled advanced nanomaterials are presented. Nanomaterials classified on basis their mode action: with intrinsic or light-mediated bactericidal properties others that serve as vehicles for delivery natural compounds. Specific attention given mechanisms structure-performance relationship. Practical applications employing these antibiotic-free also introduced. Current this field future perspectives presented stimulate technologies translation fight against infection.

Language: Английский

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Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(24), P. 13135 - 13272

Published: Oct. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Language: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Polydopamine antibacterial materials

Materials Horizons, Journal Year: 2021, Volume and Issue: 8(6), P. 1618 - 1633

Published: Jan. 1, 2021

This review focuses on the recent progress in polydopamine antibacterial materials, including their structural and functional features, preparation strategies, mechanisms, biomedical applications.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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Multifunctional Tissue-Adhesive Cryogel Wound Dressing for Rapid Nonpressing Surface Hemorrhage and Wound Repair

ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 12(32), P. 35856 - 35872

Published: July 29, 2020

Cryogels with tissue adhesion have great potential as wound dressings for rapid hemostasis uncontrollable nonpressing surface hemorrhage and healing, but their use has not been reported previously. Herein, we designed a series of antibacterial antioxidant tissue-adhesive cryogels based on quaternized chitosan (QCS) polydopamine (PDA). These had good blood cell platelet adhesion, enrichment, activation properties healing. The exhibited outstanding mechanical strength easy removability, activity, NIR photothermal-enhanced performance. showed much better than gauze gelatin sponge in standardized strip rat liver injury model, circular rabbit section pig skin laceration model. Furthermore, the excellent hemostatic performance QCS/PDA2.0 cryogel (containing 20 mg/mL QCS 2.0 PDA) coagulopathic hemorrhages was confirmed coagulation disorder In addition, promoted deep noncompressible healing effect Tegaderm film full-thickness defect Overall, these multifunctional enhanced are suitable candidates hemostat dressings.

Language: Английский

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Advanced oxidation processes for water disinfection: Features, mechanisms and prospects

Chemical Engineering Journal, Journal Year: 2020, Volume and Issue: 409, P. 128207 - 128207

Published: Dec. 25, 2020

Language: Английский

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