2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(51)

Published: Oct. 16, 2021

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) designed as piezoelectric glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, GSH‐activated (GBMO) exhibit an oxygen‐deficient structure, which promote separation electron–hole pairs, thereby enhancing efficiency in The GBMO piezoelectric, ultrasonic waves introduce mechanical strain nanoribbons, resulting polarization band tilting, thus accelerating toxic production. as‐synthesized enable excellent computed tomography imaging tumors significant tumor suppression vitro vivo. A sonosensitizer‐mediated two‐step enhancement SDT process, is activated by amplified exogenous ultrasound, proposed. This process not only provides new options improving but also broadens application materials

Language: Английский

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Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 445, P. 214087 - 214087

Published: June 28, 2021

Language: Английский

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Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Advanced Science, Journal Year: 2021, Volume and Issue: 8(10)

Published: March 12, 2021

As a novel noninvasive therapeutic modality combining low-intensity ultrasound and sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its high tissue-penetrating capability treat deeper lesions intractable by photodynamic (PDT), which suffers from the major limitation of low tissue penetration depth light. The effectiveness feasibility SDT are regarded rely on not only development stable flexible apparatus, but also screening sonosensitizers with good specificity safety. To give an outlook equipment, key technologies discussed according five aspects including ultrasonic dose settings, sonosensitizer screening, tumor positioning, temperature monitoring, reactive oxygen species (ROS) detection. In addition, some state-of-the-art multifunctional equipment integrating diagnosis treatment accurate introduced. Further, overview provided small molecular sensitizers nano/microenhanced sensitizers. Several types nanomaterial-augmented in discussion, porphyrin-based nanomaterials, porphyrin-like inorganic organic-inorganic hybrid nanomaterials different strategies improve efficacy. There no doubt that rapid will be promoted advanced smart nanomaterial-based sonosensitizer, multidisciplinary collaboration.

Language: Английский

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Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(49)

Published: Oct. 4, 2022

The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field cancer treatment. Herein, a new strategy based on triarylboron-doped acenethiophene scaffolds presented. attachment boron to linear acenethiophenes lowers lowest unoccupied molecular orbital (LUMO) energy, resulting redshifted absorptions and emissions. After encapsulation with amphiphilic polymer DSPE-mPEG2000 , it found that nanostructured BAnTh-NPs BTeTh-NPs (nanoparticles BAnTh BTeTh) shows hydroxyl radical (• OH) generation under ultrasound (US) irradiation aqueous solution almost no phototoxicity, which can overcome shortcomings O2 -dependent SDT avoid potential cutaneous phototoxicity issue. In vitro vivo therapeutic results validate boron-doped as enable high efficiency low good biocompatibility, indicating boron-functionalization acenes promising toward SDT.

Language: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

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Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 23, 2023

Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic nanoparticles enable receive convert signals into heat, thereby initiating of lysis proteins under control a heat-sensitive promoter. then lyse, releasing its anti-CD47 nanobody cargo, that is pre-expressed within bacteria. robust immunogenicity lysate cooperates activate both innate adaptive immune responses, generating antitumor effects against not only but also distal mice. magnetically constant field-controlled motion enhanced targeting increased therapeutic efficacy. Thus, behavior can manipulated vivo field, achieving tumor-specific CD47 blockage precision immunotherapy.

Language: Английский

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Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4102 - 4133

Published: Feb. 21, 2023

Sonodynamic therapy (SDT) has emerged as a promising therapeutic modality for anticancer treatments and is becoming cutting-edge interdisciplinary research field. This review starts with the latest developments of SDT provides brief comprehensive discussion on ultrasonic cavitation, sonodynamic effect, sonosensitizers in order to popularize basic principles probable mechanisms SDT. Then recent progress MOF-based overviewed, preparation methods properties (e.g., morphology, structure, size) products are presented fundamental perspective. More importantly, many deep observations understanding toward MOF-assisted strategies were described applications, aiming highlight advantages improvements MOF-augmented synergistic therapies. Last but not least, also pointed out challenges technological potential future advance. In all, discussions summaries will promote fast development nanodrugs biotechnologies.

Language: Английский

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Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(28)

Published: May 7, 2022

Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by "always-on" pharmacological activities therapeutic agents and lack efficient sonosensitizers. Herein, development semiconducting polymers as sonosensitizers further sono-immunotherapeutic nanobodies (SPNAb ) for activatable sono-immunotherapy reported. Conjugation anti-CTLA-4 antibodies onto polymer nanoparticles through a 1 O2 -cleavable linker affords SPNAb with relatively low CTLA-4 binding affinity. Upon sono-irradiation, generates not only to elicit effect induce immunogenic cell death, but also release trigger situ checkpoint blockade. Such synergistic action mediated modulates tumoricidal function T-cell immunity promoting proliferation cytotoxic T lymphocytes depleting immunosuppressive regulatory cells, resulting effective tumor regression, metastasis inhibition, durable immunological memory, prevention relapse. Therefore, this study represents proof-of-concept strategy using precise spatiotemporal control over immunotherapy.

Language: Английский

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An Intelligent Cell-Derived Nanorobot Bridges Synergistic Crosstalk Between Sonodynamic Therapy and Cuproptosis to Promote Cancer Treatment

Nano Letters, Journal Year: 2023, Volume and Issue: 23(7), P. 3038 - 3047

Published: March 23, 2023

Recent progress in cuproptosis sheds light on the development of treatment approaches for advancing sonodynamic therapy (SDT) due to its unique cell death mechanism. Herein, we elaborately developed an intelligent cell-derived nanorobot (SonoCu), composed macrophage-membrane-camouflaged nanocarrier encapsulating copper-doped zeolitic imidazolate framework-8 (ZIF-8), perfluorocarbon, and sonosensitizer Ce6, synergistically triggering cuproptosis-augmented SDT. SonoCu not only improved tumor accumulation cancer-cell uptake through cell-membrane camouflaging but responded ultrasound stimuli enhance intratumor blood flow oxygen supply, which consequently overcame barriers activated cuproptosis. Importantly, SDT effectiveness could be further amplified by multiple mechanisms, including reactive species accumulation, proteotoxic stress, metabolic regulation, sensitized cancer death. Particularly, exhibited ultrasound-responsive cytotoxicity against cells healthy cells, endowing it with good biosafety. Therefore, present first anticancer combination cuproptosis, may inspire studies pursuing a rational multimodal strategy.

Language: Английский

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Combined photothermal and sonodynamic therapy using a 2D black phosphorus nanosheets loaded coating for efficient bacterial inhibition and bone-implant integration

Biomaterials, Journal Year: 2023, Volume and Issue: 297, P. 122122 - 122122

Published: April 11, 2023

Language: Английский

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