Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 33(9), P. 4146 - 4156
Published: Feb. 22, 2022
Language: Английский
Matter, Journal Year: 2022, Volume and Issue: 5(5), P. 1502 - 1519
Published: March 11, 2022
Language: Английский
Citations
44
Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(26)
Published: April 6, 2022
Photolysis-based prodrug strategy can address some critical drug delivery issues, which otherwise are very challenging to tackle with traditional strategy. However, the need for external light irradiation significantly hampers its in vivo application due poor accessibility of deep tissue. Herein, we propose a new chemiexcitation-triggered activation, wherein photoresponsive is excited payload release by chemiexcitation instead photoirradiation. As such, bond-cleavage power photolysis be employed issues while obviating irradiation. We have established proof concept successful development responsive carbon monoxide platform, exhibited specific CO at tumor site and pronounced suppression effects. anticipate that such activation leveraged targeted other small molecule-based payloads.
Language: Английский
Citations
39
Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(40)
Published: July 4, 2022
Abstract Metal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. This field is particularly developed applications in oncology. More precisely, tumor‐associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) exploited to trigger selective delivery active drugs tumor site. The main advances this area are discussed Review.
Language: Английский
Citations
39
Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 10
Published: Jan. 4, 2023
Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both healthy cells, causing a variety adverse effects such as lack specificity, cytotoxicity, short half-life, poor solubility, multidrug resistance, acquiring stem-like characteristics. There paradigm shift in drug delivery systems (DDS) with advent smarter ways targeted treatment. Smart Drug Delivery Systems (SDDSs) stimuli responsive be modified chemical structure response to light, pH, redox, magnetic fields, enzyme degradation future translational medicine. Therefore, SDDSs have potential used viable alternative traditional chemotherapy. This review focuses mostly on delivery, inorganic nanocarriers (Carbon nanotubes, gold nanoparticles, Meso-porous silica quantum dots etc. ), organic (Dendrimers, liposomes, micelles), antibody-drug conjugates (ADC) small molecule (SMDC) based for therapy strategies cells.
Language: Английский
Citations
32
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5706 - 5743
Published: Jan. 1, 2023
Integrated development of designer chemical tools and complementary analytical technologies empowers new scientific clinical opportunities.
Language: Английский
Citations
31
Advanced Science, Journal Year: 2023, Volume and Issue: 10(16)
Published: April 7, 2023
Abstract Targeting cancer cells with high specificity is one of the most essential yet challenging goals tumor therapy. Because different surface receptors, transporters, and integrins are overexpressed specifically on cells, using these cell‐specific properties to improve drug targeting efficacy holds particular promise. Targeted fluorescent prodrugs not only intracellular accumulation bioavailability but also report their own localization activation through real‐time changes in fluorescence. In this review, efforts highlighted develop innovative targeted that efficiently accumulate organs, including lung cancer, liver cervical breast glioma, colorectal cancer. The latest progress advances chemical design synthetic considerations fluorescence prodrug conjugates how therapeutic can be activated by tumor‐specific stimuli reviewed. Additionally, novel perspectives provided strategies behind engineered nanoparticle platforms self‐assembled from prodrugs, readouts used monitor position action nanoparticle‐mediated delivery agents preclinical models. Finally, future opportunities for prodrug‐based solutions challenges accelerating clinical translation treatment organ‐specific tumors proposed.
Language: Английский
Citations
29
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2757 - 2757
Published: Feb. 1, 2023
Drug delivery systems, which use components at the nanoscale level as diagnostic tools or to release therapeutic drugs particular target areas in a regulated manner, are fast-evolving field of science. The active pharmaceutical substance can be released via drug system produce desired effect. poor bioavailability and irregular plasma levels conventional systems (tablets, capsules, syrups, etc.) prevent them from achieving sustained delivery. entire therapy process may ineffective without reliable system. To achieve optimal safety effectiveness, must also administered precision-controlled rate targeted spot. issues with traditional overcome by development stimuli-responsive controlled release. Over past decades, has evolved considerably, progressing large- smart-controlled for several diseases. current review provides an updated overview recent developments boron-based materials various Boron-containing compounds such boron nitride, boronic acid, dipyrromethene have been developed moving research Due their ability precise control over through response stimuli (pH, light, glutathione, glucose temperature), attracting lot attention. potential developing capabilities wide range nanoparticles, nanosheets/nanospheres, nanotubes, nanocarriers, microneedles, nanocapsules, hydrogel, nanoassembly, etc., is addressed examined. This overall design principles include nanomaterial-based might inspire new concepts applications.
Language: Английский
Citations
27
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)
Published: March 24, 2023
Abstract Membrane decorated with biocides is an effective way to suppress biofilm growth. However, their immediate biocidal effect usually suffers from a significant decline due the irreversible consumption of biocides. Here, smart nanofiltration membrane reported rechargeable antibacterial capability that fabricated by facile interfacial polymerization via 3‐aminophenylboronic acid and trimesoyl chloride on polysulfone substrate. Biocides bearing diol groups can be grafted onto surface under neutral/alkaline condition then released acidic environment, pH‐responsive feature boronate ester complexes. The resultant exhibits integrated properties fast bacterial inactivating efficiency, capability, impressive stability. In addition, achieved shows remarkable separation efficiency dye/monovalent salt system. successful fabrication anti‐bacterial property provides new insights into development sustainable membranes.
Language: Английский
Citations
24
Exploration, Journal Year: 2024, Volume and Issue: 4(4)
Published: Jan. 18, 2024
Molecular imaging is a non-invasive method that widely used for visualization and detection of biological events at cellular or molecular levels. Stimuli-responsive linkers can be selectively cleaved by specific biomarkers desired sites to release activate agents are appealing tools improve the specificity, sensitivity, efficacy imaging. This review summarizes recent advances stimuli-responsive their application in imaging, highlighting potential these design activatable probes. It hoped this could inspire more research interests development responsive associated applications.
Language: Английский
Citations
15
Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3121 - 3121
Published: June 30, 2024
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors the cGAS-STING have been developed evaluated for treatment various diseases. aim to activate STING, with dinucleotides (CDNs) being most common, while block enzymatic activity or DNA binding ability cGAS. Meanwhile, non-CDN compounds cGAS are also gaining attention. omnipresence vivo indicates that its overactivation could lead undesired inflammatory responses autoimmune diseases, which underscores necessity developing both pathway. This review describes molecular traits roles summarizes development inhibitors. information supposed be conducive design novel drugs targeting
Language: Английский
Citations
15