Cited by Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies

Emerging ultrasmall luminescent nanoprobes for in vivo bioimaging DOI

Shihua Li, Jing Wei, Qiaofeng Yao

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(5), P. 1672 - 1696

Published: Jan. 1, 2023

Ultrasmall luminescent nanoprobes have shown some unique imaging advantages and application scenarios. In this review, we present a comprehensive summary discussion of ultrasmall towards in vivo PL bioimaging.

Language: Английский

Citations

Nucleic acid drug vectors for diagnosis and treatment of brain diseases DOI

Zhiguo Lü, Jie Shen, H. J. Yang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 17, 2023

Abstract Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They been demonstrated to irreplaceable superiority brain disease treatment, while vectors are a decisive factor therapeutic efficacy. Strict physiological barriers, such as degradation clearance circulation, blood-brain barrier, cellular uptake, endosome/lysosome release, obstruct delivery nucleic by vectors. against single inefficient treating diseases complex pathogenesis. Differences between individual patients lead severe uncertainties treatment with drugs. In this Review, we briefly summarize classification Next, discuss barriers during drug universal coping strategies introduce application methods these Subsequently, explore drug-based multidrug regimens for combination construction corresponding following, address feasibility patient stratification personalized therapy through diagnostic information from medical imaging manner introducing contrast agents into Finally, take perspective on future remaining challenges vector-based integrated diagnosis gene diseases.

Language: Английский

Citations

Lipid nanoparticles for siRNA delivery in cancer treatment DOI

Souhaila H. El Moukhtari, Elisa Garbayo, Ane Amundarain

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 130 - 146

Published: Aug. 4, 2023

Language: Английский

Citations

Nanocellulose: a review on preparation routes and applications in functional materials DOI

Yungeng Qi,

Yanzhu Guo,

Afroza Akter Liza

et al.

Cellulose, Journal Year: 2023, Volume and Issue: 30(7), P. 4115 - 4147

Published: April 6, 2023

Language: Английский

Citations

Advances and Prospects in Integrated Nano-oncology DOI

Jinlei Jiang,

Xinyuan Cui,

Yixin Huang

et al.

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(2), P. 152 - 187

Published: Feb. 5, 2024

In recent years, the deep integration of basic research and clinical translational nanotechnology oncology has led to emergence a new branch, namely integrated nano-oncology. This is an emerging important interdisciplinary field, which plays irreplaceable role in diagnosis, treatment, early warning, monitoring prevention tumors, become frontier. Here main advances nano-oncology was reviewed, mainly included controlled preparation nanomaterials, ultra-sensitive detection tumor biomarkers, multi-functional nanoimaging probes diagnosis treatment technology, innovative nano drugs drug delivery system, DNA nanotechnology, RNA self-assembly nanosensors, intelligent nanorobots, nanotherapeutic machines. The terms, concepts, trends challenges are also discussed with aim promoting application solving scientific key technical problems cancer.

Language: Английский

Citations

Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor DOI

Tiantian Liu, Zehang Zhou, Mengxing Zhang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 502 - 512

Published: Sept. 9, 2023

Language: Английский

Citations

Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis DOI

Shoupeng Cao, Tsvetomir Ivanov,

Julian Heuer

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless organelles. Their biomimetic properties, such molecular crowding selective partitioning, make them promising components for designing cell-like materials. However, their use artificial has been limited by complex structure, control over internal microenvironment inherent colloidal instability. Here we report the design dipeptide coacervates that exhibit enhanced stability, biocompatibility, hydrophobic microenvironment. The character facilitates encapsulation species, including transition metal-based catalysts, enhancing efficiency in aqueous environments. Dipeptide carrying catalyst are incorporated active cells trigger an chemical reaction. development with opens alternative avenue field materials applications catalysis synthetic biology.

Language: Английский

Citations

Entry and exit of extracellular vesicles to and from the blood circulation DOI

Dalila Iannotta,

A Amruta,

Amanda W. Kijas

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 19(1), P. 13 - 20

Published: Dec. 18, 2023

Language: Английский

Citations

CARBON DOTS: Bioimaging and Anticancer Drug Delivery DOI

Michał Bartkowski, Yingru Zhou,

Mustafa Nabil Amin Mustafa

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(19)

Published: Jan. 11, 2024

Abstract Cancer, responsible for approximately 10 million lives annually, urgently requires innovative treatments, as well solutions to mitigate the limitations of traditional chemotherapy, such long‐term adverse side effects and multidrug resistance. This review focuses on Carbon Dots (CDs), an emergent class nanoparticles (NPs) with remarkable physicochemical biological properties, their burgeoning applications in bioimaging nanocarriers drug delivery systems cancer treatment. The initiates overview NPs nanocarriers, followed by in‐depth look into barriers that could affect distribution, from administration, intracellular trafficking. It further explores CDs′ synthesis, including both bottom‐up top‐down approaches, notable biocompatibility, supported a selection vitro, vivo , ex studies. Special attention is given role bioimaging, highlighting optical properties. discussion extends emerging significance carriers, particularly doxorubicin other anticancer agents, underscoring recent advancements challenges this field. Finally, we showcase examples promising bioapplications CDs, owing flexible design. As research CDs evolves, envisage key challenges, potential CD‐based therapy.

Language: Английский

Citations

Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations