Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(42)

Published: July 23, 2021

Abstract Excessive and unwarranted administration of antibiotics has invigorated the evolution multidrug‐resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short‐lived ion‐pair structures are highly tunable have diverse applications. Apart from their unique physicochemical features, newly discovered biological activities ionic fascinated biochemists, microbiologists, medical scientists. In particular, antimicrobial properties opened new vistas in overcoming current challenges associated combating antibiotic‐resistant pathogens. Discussions regarding liquid derivatives monomeric polymeric forms presented here. The mechanism parameters that affect activities, such as chain length, cation/anion type, cation density, polymerization, considered. potential applications biomedical arena, including regenerative medicine, biosensing, drug/biomolecule delivery, to stimulate scientific community further improve efficacy liquids.

Language: Английский

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Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6793 - 6793

Published: June 24, 2021

Quaternary ammonium compounds (QACs) belong to a well-known class of cationic biocides with broad spectrum antimicrobial activity. They are used as essential components in surfactants, personal hygiene products, cosmetics, softeners, dyes, biological antiseptics, and disinfectants. Simple but varied their structure, QACs divided into several subclasses: Mono-, bis-, multi-, poly-derivatives. Since the beginning 20th century, significant amount work has been dedicated advancement this biocides. Thus, more than 700 articles on were published only 2020, according modern literature. The structural variability diverse activity ionic liquids (ILs) make them highly prospective for developing new types ILs bear common key element molecular structure-quaternary positively charged nitrogen atoms within cyclic or acyclic framework. state-of-the-art research level paramount demand society recall rapid development generation tunable antimicrobials. This review focuses main exhibiting antifungal properties, commercial products based QACs, latest discoveries connected biocide development.

Language: Английский

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Ionic liquids in pharmaceutical industry: A systematic review on applications and future perspectives

Journal of Molecular Liquids, Journal Year: 2021, Volume and Issue: 349, P. 118145 - 118145

Published: Nov. 20, 2021

Language: Английский

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Ionic-Liquid-Catalyzed Approaches under Metal-Free Conditions

Accounts of Chemical Research, Journal Year: 2021, Volume and Issue: 54(16), P. 3172 - 3190

Published: July 30, 2021

ConspectusMetal-free catalysis is a promising protocol to access chemicals without metal contamination. Ionic liquids (ILs) that are entirely composed of organic cations and inorganic/organic anions have emerged as alternatives molecular solvents catalysts due their unique properties such structural tunability, the coexistence multiple interactions among ions (e.g., electrostatic interaction, hydrogen bonding, van de Waals forces, acid/base interactions, hydrophilic/hydrophobic etc.), affinity for wide range chemicals, good chemical thermal stability, quite low volatility. ILs shown potential applications in various processes.In this Account, we systematically described our most recent work on IL-catalyzed approaches under metal-free conditions. The first section presents strategies toward transformation CO2 value-added focusing CO2-reactive heterocycles reductive chemicals. In these approaches, designed task-specific able chemically capture activate via forming anion-based carbonate/carbamate or cation-based carboxylate/carbamate intermediates, thus further accomplishing its series including quinazoline-2,4(1H,3H)-diones, cyclic carbonates, 2-oxazolidinones, oxazolones, benzimidazolones For reducing with hydrosilanes employed capable activating Si–H bond N–H amine substrates H-bonding, achieving formamides, benzimidazoles, benzothiazoles cooperative catalysis. second describes finding hydration C≡C propargylic alcohols. Azolate can formation carbamates could serve robust nucleophiles attack alcohols then efficiently catalyze produce α-hydroxy ketones assistance atmospheric gas third unveils strategy donors acceptors reactions. hydrogen-bonding protocols, act H-bond anions, acceptors, H-bonds reactant molecules, respectively, opposite ways, which cooperatively ring-closing C–O/C–O metathesis reactions aliphatic diethers O-heterocycles, dehydrative etherification ethers, direct oxidative esterification esters. We believe processes display practical applications, commercialization would bring great benefits production as-afforded

Language: Английский

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Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(17), P. 19745 - 19755

Published: April 23, 2021

Chemotherapeutic cytotoxic agents such as paclitaxel (PTX) are considered essential for the treatment of various cancers. However, PTX injection is associated with severe systemic side effects and high rates patient noncompliance. Micelle formulations (MFs) nano-drug delivery systems that offer a solution to these problems. Herein, we report an advantageous carrier transdermal comprising new MF consists two biocompatible surfactants: cholinium oleate ([Cho][Ole]), which surface-active ionic liquid (SAIL), sorbitan monolaurate (Span-20). A solubility assessment confirmed was readily solubilized in SAIL-based micelles via multipoint hydrogen bonding cation−π π–π interactions between SAIL[Cho][Ole]. Dynamic light scattering (DLS) transmission electron microscopy revealed presence PTX, formed spherical PTX-loaded were well-distributed range 8.7–25.3 nm. According DLS, sizes size distributions micelle droplets did not change significantly over entire storage period, attesting their physical stability. In vitro assessments using Franz diffusion cell absorbed 4 times more effectively than Tween 80-based formulation 6 ethanol-based formulation. vivo skin irritation tests had negligible toxicity profile compared conventional liquid-based carrier. Based on findings, believe SAIL[Cho][Ole]-based has potential nanocarrier effective poorly soluble chemotherapeutics PTX.

Language: Английский

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Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(36), P. 42461 - 42472

Published: Aug. 30, 2021

Since injection administration for diabetes is invasive, it important to develop an effective transdermal method insulin. However, delivery remains challenging owing the strong barrier function of stratum corneum (SC) skin. Here, we developed ionic liquid (IL)-in-oil microemulsion formulations (MEFs) insulin using choline–fatty acids ([Chl][FAs])—comprising three different FAs (C18:0, C18:1, and C18:2)—as biocompatible surface-active ILs (SAILs). The MEFs were successfully [Chl][FAs] as surfactants, sorbitan monolaurate (Span-20) a cosurfactant, choline propionate IL internal polar phase, isopropyl myristate continuous oil phase. Ternary phase behavior, dynamic light scattering, transmission electron microscopy studies revealed that thermodynamically stable with nanoparticle size. significantly enhanced permeation via intercellular route by compromising tight lamellar structure SC lipids through fluidity-enhancing mechanism. In vivo low doses (50 IU/kg) diabetic mice showed reduced blood glucose levels (BGLs) compared commercial surfactant-based formulation increasing bioavailability in systemic circulation sustained level much longer period (half-life > 24 h) than subcutaneous 1.32 h). When [Chl][C18:2] SAIL-based MEF was transdermally administered, BGL 56% its initial value. nontoxic (cell viability 90%). They remained at room temperature 3 months their biological activity retained 4 °C. We believe will alter current approaches therapy may be potential nanocarrier protein peptide delivery.

Language: Английский

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Emerging impacts of ionic liquids on eco-environmental safety and human health

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(24), P. 13609 - 13627

Published: Jan. 1, 2021

This review highlights the emerging impacts of ionic liquids on eco-environmental safety and human health, which will accelerate our understanding issues serve as a guideline for design next generation liquids.

Language: Английский

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Ionic liquid-based gels for biomedical applications

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 452, P. 139248 - 139248

Published: Sept. 16, 2022

Language: Английский

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Ionic liquids as protein stabilizers for biological and biomedical applications: A review

Biotechnology Advances, Journal Year: 2022, Volume and Issue: 61, P. 108055 - 108055

Published: Oct. 29, 2022

Biotechnology has revolutionized science and health care by providing new biomolecules with biological medical applications. However, the low stability of several life-saving bioproducts still hinders their transport, storage, application. Hence, protein-based instability high costs are main bottlenecks limiting access to biopharmaceuticals in low-income countries communities. Aiming improve products, researchers have studied ionic liquids (ILs) as protein stabilizers due unique properties ability enhance solubility a wide range biomolecules. Although different classes ILs potential stability, effects dependent on variables, such complex intrinsic proteins, nature concentration ILs, environmental conditions (e.g., temperature, pH). For applications, biocompatibility can also limit use. Therefore, current state-of-the-art applications for non-enzymatic stabilization was carefully analyzed discussed, considering properties, classes, IL solutions concentrations. Lastly, critical perspective regarding presented, highlighting lacunas field while guiding future studies answer existing paradigms.

Language: Английский

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Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1179 - 1179

Published: April 7, 2023

The development of effective drug formulations and delivery systems for newly developed or marketed molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, systemic toxicity, be difficult to formulate with traditional organic solvents due acute toxicity. Ionic liquids (ILs) are recognized as that improve the pharmacokinetic pharmacodynamic properties drugs. ILs address operational/functional challenges associated solvents. However, many non-biodegradable inherently toxic, which is most challenge in developing IL-based systems. Biocompatible comprising biocompatible cations anions mainly derived from bio-renewable sources considered green alternative both conventional organic/inorganic This review covers technologies strategies design ILs, focusing on systems, discusses advantages these pharmaceutical biomedical applications. Furthermore, this will provide guidance transitioning rather than commonly used toxic fields ranging chemical synthesis pharmaceutics.

Language: Английский

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