Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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Realizing selective detection with nanozymes: Strategies and trends

TrAC Trends in Analytical Chemistry, Journal Year: 2021, Volume and Issue: 143, P. 116379 - 116379

Published: June 25, 2021

Language: Английский

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Insights on catalytic mechanism of CeO2 as multiple nanozymes

Nano Research, Journal Year: 2022, Volume and Issue: 15(12), P. 10328 - 10342

Published: July 11, 2022

Language: Английский

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Dimensionality Engineering of Single-Atom Nanozyme for Efficient Peroxidase-Mimicking

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(30), P. 16835 - 16842

Published: July 24, 2023

In nature, enzymatic reactions occur in well-functioning catalytic pockets, where substrates bind and react by properly arranging the sites amino acids a three-dimensional (3D) space. Single-atom nanozymes (SAzymes) are new type of with active similar to those natural metalloenzymes. However, centers current SAzymes two-dimensional (2D) architectures lack collaborative substrate-binding features limits their activity. Herein, we report dimensionality engineering strategy convert conventional 2D Fe–N-4 into 3D structures integrating oxidized sulfur functionalities onto carbon plane. Our results suggest that could serve as binding for assisting substrate orientation facilitating desorption H2O, resulting an outstanding specific activity up 119.77 U mg–1, which is 6.8 times higher than FeN4C SAzymes. This study paves way rational design highly single-atom nanozymes.

Language: Английский

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Rational Construction of a Ni/CoMoO₄ Heterostructure with Strong Ni–O–Co Bonds for Improving Multifunctional Nanozyme Activity

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4536 - 4550

Published: March 3, 2022

Due to the lack of a general descriptor predict activity nanomaterials, current exploration nanozymes mainly depended on trial-and-error strategies, which hindered effective design nanozymes. Here, with help large number Ni–O–Co bonds at interface heterostructures, prediction was successfully determined reveal double enzyme-like mechanisms for Ni/CoMoO4. Additionally, DFT calculations revealed that engineering could accelerate catalytic kinetics activity. were main active sites Finally, colorimetric signal and intelligent biosensor Ni/CoMoO4 based deep learning used detect organophosphorus ziram sensitively. Meanwhile, in situ FTIR results uncovered detection mechanism: target molecules block heterostructure leading peak decreasing. This study not only provided well strategy further development or other advanced catalysts, but it also designed multifunctional platform. Furthermore, preferable ideas regarding mechanism

Language: Английский

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Confined construction of COF@Cu-nanozyme with high activity and stability as laccase biomimetic catalyst for the efficient degradation of phenolic pollutants

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 448, P. 137701 - 137701

Published: June 21, 2022

Language: Английский

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Chiral Materials: Progress, Applications, and Prospects

Small, Journal Year: 2023, Volume and Issue: 19(38)

Published: May 22, 2023

Abstract Chirality is a universal phenomenon in molecular and biological systems, denoting an asymmetric configurational property where object cannot be superimposed onto its mirror image by any kind of translation or rotation, which ubiquitous on the scale from neutrinos to spiral galaxies. plays very important role life system. Many molecules body show chirality, such as “codebook” earth's diversity‐DNA, nucleic acid, etc. Intriguingly, living organisms hierarchically consist homochiral building blocks, for example, l ‐amino acids d ‐sugars with unknown reason. When chirality interact these chiral factors, only one conformation favors positive development life, that is, host environment can selectively conformations. The differences interactions are often manifested recognition, mutual matching, molecules, means stereoselectivity produce changes pharmacodynamics pathology. Here, latest investigations summarized including construction applications materials based natural small source, biomacromolecules sources, material synthesized design source.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Bioinspired construction of histidine-doped porphyrin covalent organic framework nanozyme with enhanced peroxidase-like activity for sensitive uric acid detection

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 146979 - 146979

Published: Oct. 28, 2023

Language: Английский

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Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215937 - 215937

Published: June 15, 2024

Language: Английский

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