Icing on the cake: combining a dual PEG-functionalized pillararene and an A-D-A small molecule photosensitizer for multimodal phototherapy

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1134 - 1141

Published: May 10, 2022

Language: Английский

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The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade^†‡

Photochemistry and Photobiology, Journal Year: 2022, Volume and Issue: 99(2), P. 356 - 419

Published: Sept. 26, 2022

Abstract This review follows the research, development and clinical applications of photosensitizer 5,10,15,20‐tetra( m ‐hydroxyphenyl)chlorin ( THPC, temoporfin) in photodynamic (cancer) therapy (PDT) other medical applications. Temoporfin is active substance medicinal product Foscan® authorized EU for palliative treatment head neck cancer. Chemistry, biochemistry pharmacology, as well temoporfin are addressed, including extensive work that has been done on formulation liposomal formulations. The literature covered from 2009 to early 2022, thereby connecting it previous this published journal [Senge, M. O. J. C. Brandt (2011) Photochem. Photobiol. 87, 1240–1296] which followed its way initial approval application.

Language: Английский

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Mesoporous silicas in materials engineering: Nanodevices for bionanotechnologies

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100472 - 100472

Published: Oct. 21, 2022

In this review, the most valuable opportunities offered by mesoporous silica nanoparticles in field of development nanodevices for bionanotechnology applications are reviewed. The state art is critically discussed with particular emphasis on cancer-related application, paying attention to all aspects design and process that engineers selective administration an anticancer agent cancer tissues. analyses critical factors limit taken into account technical solutions proposed face these discussed. Furthermore, targeting difficult tissues forefront such as immunotherapy, diagnostic, theranostic, gene therapy considered. Lastly, authors provide their opinion reasons according which translation generation from laboratory research practical clinical eventually market possible.

Language: Английский

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Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(5)

Published: March 5, 2022

Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of broad range diseases, including oncological and infectious diseases. This minimally invasive localized is based on production reactive oxygen species able to destroy cancer cells inactivate pathogens by combining use photosensitizers (PSs), light, molecular oxygen. To overcome drawbacks drug systemic administration, delivery systems (DDS) can be used carrier PSs, allowing higher therapeutic efficacy minimal toxicological effects. Polymeric nanofibers produced electrospinning emerged as powerful platforms applications. Electrospun exhibit outstanding characteristics, such large surface-area-to-volume ratio associated with high loading, porosity, flexibility, ability incorporate release wide variety agents, biocompatibility, biodegradability. Due versatility this technique, fibers different morphologies functionalities, profile produced. The possibility scalability makes even more attractive development DDS. review aims explore show an up date huge potential electrospun DDS PDT applications discuss opportunities challenges in field.

Language: Английский

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Carbon dots with two-photon fluorescence imaging for efficient synergistic trimodal therapy

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 34(9), P. 108197 - 108197

Published: Feb. 10, 2023

Language: Английский

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