Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry DOI Creative Commons
Wenjie Zhang, Wenzhi Yang, Jiong Zhou

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4422 - 4422

Published: May 29, 2023

The development of supramolecular chemistry has always been accompanied by the innovation macrocyclic hosts. synthesis novel macrocycles with unique structures and functions will bring new opportunities for chemistry. As a generation hosts, biphenarenes have customizable cavity sizes diverse backbones, overcoming limitation that cavities traditionally popular hosts are generally smaller than 10 Å. These features undoubtedly endow distinguished host-guest properties, which attracted more attention. In this review, structural characteristics molecular recognition properties summarized. addition, applications in adsorption separation, drug delivery, fluorescence sensing other fields introduced. Hopefully, review provide reference study arenes, especially biphenarenes.

Language: Английский

Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia DOI
Bingli Lu, Lingyun Wang, Hao Tang

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4600 - 4618

Published: Jan. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Language: Английский

Citations

59
Organic conjugated small molecules with donor–acceptor structures: design and application in the phototherapy of tumors DOI
Bing Lü, Yuying Huang, Zhecheng Zhang

et al.

Materials Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 6(20), P. 2968 - 2993

Published: Jan. 1, 2022

This review summarizes organic conjugated small-molecule photosensitizers with D–A, D–A–D and A–D–A structures in phototherapy applications, highlighting some effective molecular design strategies proposing future perspectives opportunities.

Language: Английский

Citations

39
Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice DOI
Guiquan Zhang, Xuemei Chen, Xu Chen

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14800 - 14813

Published: July 24, 2023

The development of functional materials for tumor immunogenicity enhancement is desirable overcoming the low therapeutic efficiency and easy metastasis during treatments. Herein, thermoresponsive nanoparticles composed photothermal agent (PTA) click reactive reagent are developed enhanced immunotherapy application. A Ni-bis(dithiolene)-containing PTA with intense near-infrared absorption efficient conversion construction. generated heat by encapsulated further induces phase transition release chemotherapy to react amino groups on proteins, realizing PTT simultaneously. Moreover, immunogenic cell death (ICD) cancer cells evoked could be released reagent. As a result, synergistic effect treatment reaction-mediated can suppress growth primary tumor, ICD activate immune response suppression distant tumor. This strategy provides reliable promising approach in clinic.

Language: Английский

Citations

35
End Group Nonplanarization Enhances Phototherapy Efficacy of A–D–A Fused-Ring Photosensitizer for Tumor Phototherapy DOI
Bing Lü,

Hui Quan,

Zhecheng Zhang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(7), P. 2831 - 2838

Published: March 10, 2023

Enhancing the phototherapy efficacy of organic photosensitizers through molecular design is a fascinating but challenging task. Herein, we propose simple strategy to first realize generation superoxide anion radical (O2•–) by A–D–A fused-ring photosensitizers. Through replacing one cyano group traditional end with an ester group, designed novel nonplanar (A unit) synthesize photosensitizer F8CA. In comparison its counterpart F8CN F8CA displays more loose packing and larger spin–orbit coupling constants. The nanoparticles showed higher photodynamic activities capability singlet oxygen (1O2), hydroxyl (•OH), O2•–, while could only generate 1O2 •OH. addition, still remain high photothermal conversion efficiency (61%). As result, perform well in hypoxia-tolerant tumor phototherapy. This study brings effective thought for

Language: Английский

Citations

25
Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy DOI
Junjie Zhang, Jiani Zhou, Longguang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: April 23, 2024

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.

Language: Английский

Citations

11
Near-Infrared II Agent with Excellent Overall Performance for Imaging-Guided Photothermal Thrombolysis DOI

Daming Zhou,

Guiquan Zhang, Jiayi Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 25144 - 25154

Published: Aug. 27, 2024

Near-infrared II (NIR-II) imaging and photothermal therapy hold tremendous potential in precision diagnosis treatment within biological organisms. However, a significant challenge is the shortage of NIR-II fluorescent probes with both high conversion coefficient (PCE) fluorescence quantum yield (Φ

Language: Английский

Citations

8
Biomimetic Seawater Evaporator Based on Organic 3D Light Capture and Suspension‐Protection Mechanism for In Situ Marine Cultivation DOI
Jingshuai Zhu, Yuqi Wang, Xiaopan Qiu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(51)

Published: Sept. 10, 2023

Abstract Efficient and durable seawater evaporation technologies are vital for expanding access to freshwater developing novel irrigation systems. Here, a photothermal material termed as Y7, characterized by its fused‐ring, small‐molecule structure, strong electron‐withdrawing end groups, is combined with an economical wood sponge. This combination used create 3D solar desalination evaporator design self‐circulating evaporative system. Mirroring the light‐capture porous structure underwater suspension of diatoms, this hydrophilic demonstrates efficient light absorption in range 300–1100 nm excellent resistance salt photobleaching. With mass only 3 mg/3.14 cm 2 , Y7‐evaporator realizes solar‐energy‐to‐vapor conversion efficiency ( η ) 91.7% water rate ṁ 1.62 kg m −2 h −1 marking new record purely organic evaporators. After process, concentration primary ions reduced five six orders magnitude. Based on these findings, situ self‐irrigation system developed using seawater, which efficiently cultivates several plant species. The results present strategy rooted enhanced effects durability, suggesting potential applications future self‐sustaining marine cultivation.

Language: Английский

Citations

19
Side Chain Programming Synchronously Enhances the Photothermal Conversion Efficiency and Photodynamic Activity of A–D–A Photosensitizers DOI

JiaChen Xia,

Hui Quan,

Yuying Huang

et al.

ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(5), P. 489 - 494

Published: April 12, 2024

Synchronously improving the photothermal conversion efficiency and photodynamic activity of organic small molecule photosensitizers is crucial for their further wide application in cancer treatment. Recently, emerging A–D–A photosensitizer-based phototherapy systems have attracted great interest due to plentiful inherent merits. Herein, we propose a design strategy with synchronously enhanced reactive oxygen species (ROS) generation efficiencies. Side chain programming carried out three (IDT-H, IDT-Br, IDT-I) containing hexyl, bromohexyl, iodohexyl side chains, respectively. Theoretical calculations confirm that bulky iodine atom could weaken intermolecular π–π stacking enhance spin–orbit coupling constants IDT-I. These molecular mechanisms enable IDT-I nanoparticles (NPs) exhibit 2.4-fold 1.7-fold higher ROS than IDT-H NPs IDT-Br NPs, respectively, as well highest efficiency. Both experimental results vitro vivo verify are perfectly qualified mission synergistic therapy. Therefore, this contribution, provide promising perspective simultaneously improved therapy ability.

Language: Английский

Citations

7
A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow DOI
Bing Lü, Zhecheng Zhang, Yuying Huang

et al.

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(74), P. 10353 - 10356

Published: Jan. 1, 2022

In the current work, we synthesized an A-D-A smallmolecule photosensitizer, denoted as DPTTIC, and a dual PEG-functionalized pillararene, WP5-8C-2PEG, used them to construct novel DPTTIC nanoparticles (NPs) displaying NIR II absorption. Under 980 nm-wavelength laser irradiation, NPs performed well in mild-temperature photothermal type I & photodynamic anti-tumor therapy.

Language: Английский

Citations

24
The design strategy for pillararene based active targeted drug delivery systems DOI
Bing Lü,

JiaChen Xia,

Yuying Huang

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(81), P. 12091 - 12099

Published: Jan. 1, 2023

This feature article comprehensively summaries three present design strategies for pillararene based active targeted DDSs, and evaluates their performance in tumor therapy application, respective strengths weaknesses.

Language: Английский

Citations

16