Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution DOI Creative Commons
Stephen D. P. Fielden

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(28), P. 18781 - 18796

Published: July 5, 2024

Covalent polymers are versatile macromolecules that have found widespread use in society. Contemporary methods of polymerization made it possible to construct sequence polymers, including block copolymers, with high precision. Such copolymers assemble solution when the blocks differing solubilities. This produces nano- and microparticles various shapes sizes. While is straightforward draw an analogy between such amphiphilic phospholipids, these two classes molecules show quite different assembly characteristics. In particular, often under kinetic control, thus producing nonequilibrium structures. leads a rich variety behaviors being observed copolymer assembly, as pathway dependence (e.g., thermal history), nonergodicity responsiveness. The dynamics polymer assemblies can be readily controlled using changes environmental conditions and/or integrating functional groups situated on external chemical reactions. perspective highlights control both pervasive useful attribute mechanics assembly. Recent examples highlighted order toggling static dynamic behavior used generate, manipulate dismantle states. New kinetics will provide endless unanticipated applications materials science, biomimicry medicine.

Language: Английский

Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications DOI Open Access
Maria Karayianni, Stergios Pispas

Journal of Polymer Science, Journal Year: 2021, Volume and Issue: 59(17), P. 1874 - 1898

Published: July 26, 2021

Abstract The self‐assembly process of block copolymers (BCPs) in solution has been at the focus extended scientific research over past several decades owing to astonishing morphological diversity and attainable complexity resulting nanoassemblies, including spheres, cylinders, lamellae, vesicles, many other complex, bicontinuous or even hierarchical structures. ever‐increasing sophistication development synthetic chemistry methods techniques led a myriad available macromolecules with varying chemical compositions, architectures, features, properties. This assortment characteristics turn plethora intriguing self‐organized polymeric nanostructures, countless possible applications nanotechnological fields relevant physics, chemistry, material science, nanomedicine, biomaterials. present review aims illuminate importance fascinating potential BCPs by highlighting recent advances emerging trends field, as well significant application‐oriented progress, through characteristic contemporary examples.

Language: Английский

Citations

160
Amphiphilic Block Copolymers: Their Structures, and Self-Assembly to Polymeric Micelles and Polymersomes as Drug Delivery Vehicles DOI Open Access
Ketan Kuperkar, Dhruvi Patel, Leonard Ionuț Atanase

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(21), P. 4702 - 4702

Published: Nov. 3, 2022

Self-assembly of amphiphilic block copolymers display a multiplicity nanoscale periodic patterns proposed as dominant tool for the 'bottom-up' fabrication nanomaterials with different levels ordering. The present review article focuses on recent updates to self-association in aqueous media into varied core-shell morphologies. We briefly describe copolymers, their types, microdomain formation bulk and micellization selective solvents. also discuss characteristic features nanoaggregates viz., polymer micelles (PMs) polymersomes. Amphiphilic (with variety hydrophobic blocks hydrophilic blocks; often polyethylene oxide) self-assemble water micelles/niosomes similar conventional nonionic surfactants high drug loading capacity. Double (DHBCs) made neutral block-neutral or block-charged can transform one become under influence stimulus (physical/chemical/biological), thus induced amphiphilicity self-assembly are discussed. Different kinds (viz. shell core-cross-linked, core-shell-corona, schizophrenic, crew cut, Janus) presented detail. Updates polymerization-induced (PISA) crystallization-driven (CDSA) provided. Polyion complexes (PICs) polyion complex (PICMs) Applications these copolymeric polymersomes nanocarriers delivery systems described.

Language: Английский

Citations

155
Group 16 conjugated polymers based on furan, thiophene, selenophene, and tellurophene DOI
Shuyang Ye, Victor Lotocki, Hao Xu

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6442 - 6474

Published: Jan. 1, 2022

This review systematically summarizes the history and recent progress in synthesis, properties, post-polymerization modifications of chalcogenophene-based homopolymers copolymers.

Language: Английский

Citations

75
Advanced supramolecular design for direct ink writing of soft materials DOI
Miao Tang,

Zhuoran Zhong,

Chenfeng Ke

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(5), P. 1614 - 1649

Published: Jan. 1, 2023

This review draws connections between top-down direct-ink-writing and bottom-up supramolecular designs. Examples of supramolecularly designed viscoelastic inks perspectives using motifs for 3D printing have been discussed.

Language: Английский

Citations

54
Microwave-associated chemistry in environmental catalysis for air pollution remediation: A review DOI Creative Commons

Chaosheng Bao,

Ana Serrano-Lotina,

Mingshuang Niu

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 142902 - 142902

Published: April 13, 2023

Microwave-assisted synthesis has attracted wide attention as an efficient and energy-saving strategy due to its unique heating mechanism. Environmental catalysts prepared via microwave process typically exhibit uniform crystal size with desired morphology, porous structure interfacial properties, which are important for the catalytic remediation of air pollution. This review first summarizes principles heating, followed by characteristics obtained catalysts. The research progress representative materials (e.g., supported metal catalysts, oxides, carbon materials) in treatment gaseous pollutants then categorized detail. Meanwhile, this compiles recent outputs environmental from perspective features reaction pathways facilitated microwave-assisted synthesis. It demonstrates that can not only improve efficiency activity but also modify selectivity tuning catalyst properties. Finally, use irradiation activate reactions is reviewed, application microwaves lead significant improvements possibility delivering energy directly materials. Nevertheless, challenges remain development highly active realize practical application. These, together prospects on using techniques provided enlightening future field research.

Language: Английский

Citations

50
Non-classical crystallization in soft and organic materials DOI
Jingshan S. Du, Yuna Bae, James J. De Yoreo

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(4), P. 229 - 248

Published: Feb. 6, 2024

Language: Английский

Citations

40
Mechanism of Action and Design of Potent Antibacterial Block Copolymer Nanoparticles DOI
Hayley C. Parkin, Steven T. G. Street,

Brent E. Gowen

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(8), P. 5128 - 5141

Published: Feb. 15, 2024

Self-assembled polymer nanoparticles are promising antibacterials, with nonspherical morphologies of particular interest as recent work has demonstrated enhanced antibacterial activity relative to their spherical counterparts. However, the reasons for this enhancement currently unclear. We have performed a multifaceted analysis mechanism action 1D nanofibers nanospheres by use flow cytometry, high-resolution microscopy, and evaluations pristine tetracycline-loaded nanoparticles. Low-length dispersity, fluorescent diblock copolymer crystalline poly(fluorenetrimethylenecarbonate) (PFTMC) core (length = 104 472 nm, height 7 width 10–13 nm) partially protonated poly(dimethylaminoethyl methacrylate) (PDMAEMA) corona 12 were prepared via seeded growth living crystallization-driven self-assembly. Their behavior was compared that analogous containing an amorphous PFTMC (diameter nm). While all uptaken into Escherichia coli W3110, crystalline-core observed cause significant bacterial damage. Drug loading studies indicated while nanoparticle in combination tetracycline, especially prominent when small (ca. 15–25 employed. Therefore, identified differences consequences size morphology control may be exploited future design potent agents overcoming resistance. This study also reinforces requirement morphological over biomedical applications, depending on size, shape, core-crystallinity.

Language: Английский

Citations

21
Synthesis of hollow platelet polymer particles by spontaneous precision fragmentation DOI
Liping Liu, Calum T. J. Ferguson,

Lingyuan Zhu

et al.

Nature Synthesis, Journal Year: 2024, Volume and Issue: 3(7), P. 903 - 912

Published: June 4, 2024

Language: Английский

Citations

18
Direct preparation of two-dimensional platelets from polymers enabled by accelerated seed formation DOI Creative Commons
Laihui Xiao, Tianlai Xia, Jian Zhang

et al.

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

Citations

3
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation DOI
Manuela R. Zimmermann, Subhas Chandra Bera, Georg Meisl

et al.

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(40), P. 16621 - 16629

Published: Sept. 28, 2021

The formation of amyloid fibrils and oligomers is a hallmark several neurodegenerative disorders, including Alzheimer's disease (AD), contributes to the pathway. To progress our understanding these diseases at molecular level, it crucial determine mechanisms rates replication. In context AD, self-replication aggregates Aβ42 peptide by secondary nucleation, leading new on surfaces existing ones, major source both smaller toxic oligomeric species. However, core mechanistic determinants, presence intermediates, as well role heterogeneities in fibril population, are challenging from bulk aggregation measurements. Here, we obtain such information monitoring directly time evolution individual TIRF microscopy. Crucially, essentially all have ability self-replicate via amplification aggregate concentration cannot be explained small fraction "superspreader" fibrils. We observe that nucleation catalytic multistep process involving attachment soluble species surface, followed conversion/detachment yield solution. Furthermore, find formed resemble parent population. This detailed level insights into key rational design potential inhibitors this process.

Language: Английский

Citations

64