Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(15), P. 3023 - 3023
Published: July 26, 2022
Nowadays,
there
are
still
numerous
challenges
for
well-known
biomedical
applications,
such
as
tissue
engineering
(TE),
wound
healing
and
controlled
drug
delivery,
which
must
be
faced
solved.
Hydrogels
have
been
proposed
excellent
candidates
these
they
promising
properties
the
mentioned
including
biocompatibility,
biodegradability,
great
absorption
capacity
tunable
mechanical
properties.
However,
depending
on
material
or
manufacturing
method,
resulting
hydrogel
may
not
up
to
specific
task
it
is
designed,
thus
different
approaches
enhance
performance
requirements
of
application
in
question.
The
main
purpose
this
review
article
was
summarize
most
recent
trends
technology,
going
through
used
polymeric
materials
popular
synthesis
methods
years,
strategies
enhancing
hydrogels'
properties,
cross-linking
manufacture
composite
hydrogels.
In
addition,
secondary
objective
briefly
discuss
other
novel
applications
hydrogels
that
past
few
years
drawn
a
lot
attention.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
17, P. 100499 - 100499
Published: Nov. 19, 2022
Millions
of
people
die
annually
due
to
uncured
wound
infections.
Healthcare
systems
incur
high
costs
treat
Tt
is
predicted
become
more
challenging
the
rise
multidrug-resistant
conditions.
During
last
decades,
smart
antibacterial
hydrogels
could
attract
attention
as
a
promising
solution,
especially
for
skin
These
are
termed
'smart'
their
response
specific
physical
and
chemical
environmental
stimuli.
To
deliver
different
drugs
particular
sites
in
controlled
manner,
various
types
crosslinking
strategies
used
manufacturing
process.
Smart
designed
provide
antimicrobial
agents
infected
or
built
from
polymers
with
inherent
disinfectant
properties.
This
paper
aims
critically
review
recent
pre-clinical
clinical
advances
using
against
infections
propose
next
best
thing
future
trends.
For
this
purpose,
an
introduction
healing
disease
presented
intelligent
responding
stimuli
introduced.
Finally,
most
investigations
discussed
related
sections.
studies
can
pave
way
producing
new
biomaterials
applications.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(10), P. 2195 - 2195
Published: Oct. 15, 2022
Liposomes
are
well-known
nanoparticles
with
a
non-toxic
nature
and
the
ability
to
incorporate
both
hydrophilic
hydrophobic
drugs
simultaneously.
As
modern
drug
delivery
formulations
produced
by
emerging
technologies,
numerous
advantages
of
liposomal
systems
over
conventional
liposomes
or
free
treatment
cancer
have
been
reported.
Recently,
liposome
nanocarriers
exhibited
high
loading
capacity,
protection,
improved
bioavailability,
enhanced
intercellular
delivery,
better
therapeutic
effect
because
resounding
success
in
targeting
delivery.
The
site
smart
responsive
liposomes,
achieved
through
changes
their
physicochemical
morphological
properties,
allows
for
controlled
release
active
compounds
under
certain
endogenous
exogenous
stimuli.
In
that
way,
multifunctional
stimuli-responsive
therapeutics
enhance
efficacy
prevention
fighting
metastases,
while
limiting
systemic
side
effects
on
healthy
tissues
organs.
Since
constitute
promising
site-targeted
anticancer
release,
this
review
focuses
recent
progress
achievements
applications.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Nov. 20, 2023
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
Gels,
Journal Year:
2022,
Volume and Issue:
8(2), P. 122 - 122
Published: Feb. 15, 2022
Inert
hydrogels
are
of
a
great
importance
in
burn
first
aid.
Hydrogel
dressings
may
be
an
alternative
to
cooling
wounds
with
streaming
water,
especially
cases
mass
casualty
events,
lack
clean
hypothermia,
or
large
extent
burns.
Hydrogels
that
contain
mostly
water
evacuate
the
heat
cumulating
skin
by
evaporation.
They
not
only
cool
wound,
but
also
reduce
pain
and
protect
wound
area
from
contamination
further
injuries.
ideally
used
during
hours
after
injury,
as
they
do
have
antimicrobial
properties
per
se,
might
prevent
infection.
The
hydrogel
matrix
enables
incorporating
active
substances
into
dressing.
forms
ammonium
salts,
nanocrystal
silver,
zinc,
growth
factor,
cytokines,
cells,
well
natural
agents,
such
honey
herbs.
Active
activity
stimulate
healing.
Numerous
experiments
on
animal
models
proved
their
safety
efficiency.
new
dressing
type
still
development.
Gels,
Journal Year:
2023,
Volume and Issue:
9(5), P. 430 - 430
Published: May 22, 2023
Alginates
are
polysaccharides
that
produced
naturally
and
can
be
isolated
from
brown
sea
algae
bacteria.
Sodium
alginate
(SA)
is
utilized
extensively
in
the
field
of
biological
soft
tissue
repair
regeneration
owing
to
its
low
cost,
high
compatibility,
quick
moderate
crosslinking.
In
addition
their
printability,
SA
hydrogels
have
found
growing
popularity
engineering,
particularly
due
advent
3D
bioprinting.
There
a
developing
curiosity
engineering
with
SA-based
composite
potential
for
further
improvement
terms
material
modification,
molding
process,
application.
This
has
resulted
numerous
productive
outcomes.
The
use
scaffolds
cells
tissues
cell
culture
an
innovative
technique
vitro
models
mimic
vivo
environment.
Especially
compared
models,
were
more
ethical
cost-effective,
they
stimulate
growth.
article
discusses
sodium
focusing
on
modification
techniques
providing
comparative
examination
properties
several
hydrogels.
review
also
covers
hydrogel
preparation
techniques,
catalogue
patents
covering
different
formulations
discussed.
Finally,
applications
future
research
areas
concerning
examined.
