Analytica Chimica Acta, Journal Year: 2022, Volume and Issue: 1229, P. 340363 - 340363
Published: Sept. 10, 2022
Language: Английский
Lab on a Chip, Journal Year: 2022, Volume and Issue: 22(24), P. 4792 - 4804
Published: Jan. 1, 2022
We present the current status, challenges, and future opportunities of inertial microfluidics.
Language: Английский
Citations
68
Lab on a Chip, Journal Year: 2022, Volume and Issue: 22(15), P. 2789 - 2800
Published: Jan. 1, 2022
Inertial microfluidics functions solely based on the fluid dynamics at relatively high flow speed. Thus, channel geometry is critical design parameter that contributes to performance of device. Four basic geometries (i.e., straight, expansion-contraction, spiral and serpentine) have been proposed extensively studied. To further enhance performance, innovative through combining two or more promising. This work explores embedding periodic concave convex obstacle microstructures in sinusoidal channels investigates their influence particle inertial focusing separation. The obstacles could significantly Dean tune range for Based this finding, we propose a cascaded device by connecting consecutively rare cell are embedded second adapt its operational rates enable functional operation both channels. Polystyrene beads breast cancer cells (T47D) spiking blood were respectively processed results indicate an outstanding separation with 3 4 orders magnitude enhancement purity samples primary ratio 0.01% 0.001%, respectively. Embedding as brings flexibility microfluidic devices, offering feasible new way combine serial processing units high-performance
Language: Английский
Citations
39
Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.
Language: Английский
Citations
1
The Analyst, Journal Year: 2021, Volume and Issue: 146(23), P. 7070 - 7086
Published: Jan. 1, 2021
Cell separation has consistently been a pivotal technology of sample preparation in biomedical research. Compared with conventional bulky cell technologies applied the clinic, based on microfluidics can accurately manipulate displacement liquid or cells at microscale, which great potential point-of-care testing (POCT) applications due to small device size, low cost, consumption, and high operating accuracy. Among various microfluidic technologies, inertial attracted attention its simple structure throughput. In recent years, many researchers have explored principles developed different channel structures, including straight channels, curved multistage channels. However, recently channels not discussed classified detail compared more widely Therefore, this review, comprehensive detailed review progress is presented. According structure, divided into (i) channel, (ii) (iii) composite (iv) integrated device. The structural development detail. And structures are reviewed, special focus variety latest related innovations Finally, future prospects for existing challenges
Language: Английский
Citations
50
Micromachines, Journal Year: 2023, Volume and Issue: 14(7), P. 1293 - 1293
Published: June 24, 2023
In recent years, the U.S. Food and Drug Administration (FDA) has seen an increase in microfluidic medical device submissions, likely stemming from advancements technologies. This trend only been enhanced during COVID-19 pandemic, as microfluidic-based test kits have used for diagnosis. To better understand implications of this emerging technology, submissions to FDA 2015 2021 containing technologies systematically reviewed identify trends applications, performance tests, standards used, fabrication techniques, materials, flow systems. More than 80% devices with platforms were found be diagnostic nature, lateral systems accounting about 35% all identified devices. A targeted analysis over 40,000 adverse event reports linked revealed that flow, operation, data output related failures are most common failure modes these types. Lastly, paper highlights key considerations developing new protocols various applications use certain analytes (e.g., blood, urine, nasal-pharyngeal swab), detection mechanisms. We anticipate would help facilitate innovation
Language: Английский
Citations
17
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 8, 2024
The ability to manipulate and focus particles within microscale fluidic environments is crucial advancing biological, chemical, medical research. Precise high-throughput particle focusing an essential prerequisite for various applications, including cell counting, biomolecular detection, sample sorting, enhancement of biosensor functionalities. Active sheath-assisted techniques offer accuracy but necessitate the introduction external energy fields or additional sheath flows. In contrast, passive methods exploit inherent fluid dynamics in achieving without actuation. This review analyzes latest developments strategies sheathless inertial focusing, emphasizing elasto-inertial microfluidic from channel structure classifications. These methodologies will serve as pivotal benchmarks broader application technologies biological manipulation. Then, prospects future development are also predicted. paper assist understanding design devices.
Language: Английский
Citations
7
Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 3, P. 100039 - 100039
Published: April 25, 2024
Breast cancer is still suffering from its poor diagnosis and the lack of effective treatment. Despite recent development some novel chemicals, which are found to have inspiring therapeutic effects in vitro, their outcomes clinic trails disappointing, mainly due suitable vehicles. Thanks ability encapsulate bio-molecules, extracellular vesicles (EVs), including exosomes, microvesicles, apoptotic bodies, hold great promise becoming a candidate breast therapy. Currently, EVs increasingly evaluated as potential indicators since they actively involved different stages development, promoting occurrence metastasis, establishing tumor ecology, growth. Moreover, also considered promising new platforms Here, we discuss applications EVs, biomarkers for drug delivery sites. The data technologies indicate applicability clinical management patients with cancer.
Language: Английский
Citations
7
Microsystems & Nanoengineering, Journal Year: 2022, Volume and Issue: 8(1)
Published: Jan. 19, 2022
In this study, we demonstrated the label-free continuous separation and enrichment of Bacillus subtilis populations based on length using viscoelastic microfluidics. B. subtilis, a gram-positive, rod-shaped bacterium, has been widely used as model organism an industrial workhorse. can be arranged in different morphological forms, such single rods, chains, clumps, which reflect differences cell types, phases growth, genetic variation, changing environmental factors. The ability to prepare with uniform is important for basic biological studies efficient applications. Here, systematically investigated how flow rate ratio, poly(ethylene oxide) (PEO) concentration, channel affected length-based cells. lateral positions cells varying morphologies straight rectangular microchannel were found dependent under co-flow Newtonian fluids. Finally, evaluated microfluidic device separate two groups by (i.e., 1-5 μm >5 μm) terms extraction purity (EP), yield (EY), factor (EF) confirmed that could heterogeneous bacteria elasto-inertial effects.
Language: Английский
Citations
25
Microfluidics and Nanofluidics, Journal Year: 2023, Volume and Issue: 27(2)
Published: Jan. 18, 2023
Language: Английский
Citations
14
Biosensors, Journal Year: 2021, Volume and Issue: 11(11), P. 464 - 464
Published: Nov. 18, 2021
Separation of micro- and nano-sized biological particles, such as cells, proteins, nucleotides, is at the heart most biochemical sensing/analysis, including in vitro biosensing, diagnostics, drug development, proteomics, genomics. However, conventional particle separation techniques are based on membrane filtration techniques, whose efficiency limited by characteristics, pore size, porosity, surface charge density, or biocompatibility, which results a reduction bioparticles various sizes types. In addition, since other methods, centrifugation, chromatography, precipitation, difficult to perform continuous manner, requiring multiple preparation steps with relatively large minimum sample volume necessary for stable bioprocessing. Recently, microfluidic engineering enables more efficient flow rapid processing small volumes rare samples, DNA, viruses, exosomes, even cells. this paper, we present comprehensive review recent advances micro-/nano-sized summarizing physical principles behind system practical examples biomedical applications.
Language: Английский
Citations
32