Edible Long‐Afterglow Photoluminescent Materials for Bioimaging

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 13, 2024

Abstract Confining luminophores into modified hydrophilic matrices or polymers is a straightforward and widely used approach for afterglow bioimaging. However, the quantum yield lifetime of related material remain unsatisfactory, severely limiting using effect especially deep‐tissue time‐resolved imaging. This fact largely stems from dilemma between biocompatibility quenching water environment. Herein an in situ metathesis promoted doping strategy presented, namely, mixing ≈10 −3 weight ratio organic‐emitter multicarboxylates with inorganic salt reactants, followed by reactions to prepare series but water‐insoluble organic–inorganic materials. leads formation edible long‐afterglow photoluminescent materials superior excellent bioimaging effect. The phosphorescence can reach dozens percent (the highest case: 66.24%), together lasting coupes seconds. Specifically, barium meal formed coronene emitter BaSO 4 matrix applied animal experiments gavage, bright stomach imaging observed instruments mobile phone after ceasing photoexcitation deep tissue penetration. allows flexible dosage during bioimaging, facilitating development real‐time probing theranostic technology.

Language: Английский

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Mechanical Stretch α‐Cyclodextrin Pseudopolyrotaxane Elastomer with Reversible Phosphorescence Behavior

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 4, 2024

Abstract Polyethylene glycol chains in two terminals of the naphthalene functional group are threaded into α‐cyclodextrin cavities to form pseudopolyrotaxane (NPR), which not only effectively induces phosphorescence by cyclodextrin macrocycle confinement, but also provides interfacial hydrogen bonding assembly function between polyhydroxy groups and waterborne polyurethane (WPU) construct elastomers. The introduction NPR endows elastomer with enhanced mechanical properties excellent room temperature phosphorescent (RTP) emission (phosphorescence remains water, acid, alkali, organic solvents, even at 160 °C high temperatures). Especially, reversible mechanically responsive behavior intensity increased three times under 200% strain) can be observed stretch recover process, owing strain‐induced microstructural changes further inhibiting non‐radiative transition vibration NPR. Therefore, changing supramolecular elastomers through stretching a new approach for luminescent materials.

Language: Английский

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Generation of Tunable Ultrastrong White‐Light Emission by Activation of a Solid Supramolecule through Bromonaphthylpyridinium Polymerization

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 12, 2022

Herein, we reported solid supramolecular bromonaphthylpyridinium polymers (P-BrNp), which exhibit tunable phosphorescence emission in the amorphous state enabled by sulfobutylether-β-cyclodextrin (SBE-β-CD) and diarylethene derivatives. The monomer BrNp gave single fluorescence at 490 nm, while an apparent room-temperature (RTP) 550 nm emerged for P-BrNp copolymers with various feed ratios. Through fluorescence-phosphorescence dual emission, P-BrNp-0.1 displayed ultrahigh white-light quantum yield of 83.9 %. Moreover, subsequent assembly SBE-β-CD further enhanced phosphorescent from 64.1 % to 71.3 %, accompanied conversion photoluminescence white yellow. Diarylethene monomers were introduced as photoswitches realize reversible RTP can be used switchable data encryption multifunctional writing ink.

Language: Английский

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Ultrafast Synthesis of Graphene‐Embedded Cyclodextrin‐Metal‐Organic Framework for Supramolecular Selective Absorbency and Supercapacitor Performance

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Aug. 27, 2023

Limited by preparation time and ligand solubility, synthetic protocols for cyclodextrin-based metal-organic framework (CD-MOF), as well subsequent derived materials with improved stability properties, still remains a challenge. Herein, an ultrafast, environmentally friendly, cost-effective microwave method is proposed, which induced graphene oxide (GO) to design CD-MOF/GOs. This applicable technique can control the crystal size of CD-MOFs from macro- nanocrystals. CD-MOF/GOs are investigated new type supramolecular adsorbent. It selectively adsorb dye molecule methylene green (MG) owing synergistic effect between hydrophobic nanocavity CDs, abundant O-containing functional groups GO in composites. Following high temperature calcination, resulting N, S co-doped porous carbons exhibit capacitance 501 F g-1 at 0.5 A , stable cycling 90.1% capacity retention after 5000 cycles. The carbon exhibits good electrochemical performance due its surface containing numerous electrochemically active sites adsorption carbonization. strategy incorporating variety molecules into optimizes properties their materials, furthering development toward fabrication zeitgeisty high-performance energy storage devices.

Language: Английский

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Insights into the Correlation of Cross‐linking Modes with Mechanical Properties for Dynamic Polymeric Networks

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(37)

Published: July 26, 2023

Simultaneously introducing covalent and supramolecular cross-links into one system to construct dually cross-linked networks, has been proved an effective approach prepare high-performance materials. However, so far, features advantages of networks compared with those possessing individual or cross-linking points are rarely investigated. Herein, on the basis comparison between polymer network (SPN), (CPN) (DPN), we reveal that dual strategy can endow DPN integrated CPN SPN. Benefiting from energy dissipative ability along dissociation host-guest complexes, shows excellent toughness ductility similar Meanwhile, elasticity in could rise structural stability a level comparable CPN, exhibiting quick deformation recovery capacity. Moreover, strongest breaking stress puncture resistance among three, proving unique property method. These findings gained our study further deepen understanding dynamic polymeric facilitate preparation elastomeric

Language: Английский

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Highly Strong and Tough Supramolecular Polymer Networks Enabled by Cryptand‐Based Host‐Guest Recognition

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 17, 2023

Supramolecular polymer networks (SPNs) demonstrate great potential in the development of smart materials owing to their attractive dynamic properties. However, as they suffer from inherent weak bonding most noncovalent cross-links, it remains a significant challenge construct SPNs with outstanding mechanical performance. Herein, we exploit cryptand/paraquat host-guest recognition motifs cross-links prepare class highly strong and tough SPNs. Unlike those supramolecular relatively binding abilities, cryptand-based interactions have high association constant steady complexing structure, which effectively stabilizes network resists deformation under external force. Such favorable structural stability endows our greatly enhanced performance, compared control-1 cross-linked by weakly complexed crown ether/secondary ammonium salt motif (tensile strength: 21.1±0.5 vs 2.8±0.1 MPa; Young's modulus: 102.6±4.8 2.1±0.3 toughness: 90.4±2.0 10.8±0.6 MJ m-3 ). Moreover, also retain abundant properties including good abilities energy dissipation, reprocessability, stimuli-responsiveness. These findings provide novel insights into preparation properties, promote high-performance intelligent materials.

Language: Английский

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Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Small, Journal Year: 2023, Volume and Issue: 19(50)

Published: Aug. 27, 2023

Abstract Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers ideal nanocarriers for delivering anticancer agents due to the explicit study their characteristics particle size, charge, biological properties such as toxicity, blood circulation time, biodistribution, cellular internalization. Here, classification, preparation, structure dendrimer micelles reviewed, specific groups modified on surface tumor active targeting, stimuli‐responsive drug release, reduced prolonged time discussed. In addition, applications summarized various platforms related cancer therapy including delivery, gene transfection, nano‐contrast imaging, combined therapy. Other tissue engineering biosensor also involved. Finally, possible challenges perspectives further

Language: Английский

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Supramolecular Dissolving Microneedle Patch Loading Hydrophobic Glucocorticoid for Effective Psoriasis Treatment

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(12), P. 15162 - 15171

Published: March 14, 2023

Glucocorticoid-based creams are commonly used for treatments of psoriatic skin lesions while showing poor permeation because the thickened stratum corneum severely limits drug absorption. Although dissolving microneedle (DMN) patches have been employed in treating disease by virtue their direct target to lesion site, conventional DMN generally fabricated from water-soluble matrix, making them difficult efficiently encapsulate hydrophobic glucocorticoids. Here, we develop a mechanically robust supramolecular composed hydroxypropyl β-cyclodextrin (HPCD) effectively and uniformly load triamcinolone acetonide (TA). The TA-loaded HPCD (TAMN) exhibits excellent mechanical performance that can easily pierce psoriasis deliver TA efficiently. Owing increased water solubility bioavailability after inclusion into HPCD, TAMN shows superior vitro inhibitory effect on immortalized human keratinocyte (HaCaT) cells. Importantly, administration twice week alleviates signs reduces expression Ki67, IL-23, IL-17 ear imiquimod-induced psoriasis-like mice. This provides promising strategy efficient treatment other diseases, greatly broadens applications materials transdermal delivery, widens range drugs DMNs.

Language: Английский

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Pillararene-Based Supramolecular Polymers for Cancer Therapy

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1470 - 1470

Published: Feb. 3, 2023

Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular with tunable physicochemical properties, self-healing, externally stimulated responses. Among them, pillararene-based show great potential for biomedical applications fascinating host–guest easy modification. Herein, we summarize the state art cancer therapy illustrate its developmental trend future perspective.

Language: Английский

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Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Beilstein Journal of Nanotechnology, Journal Year: 2023, Volume and Issue: 14, P. 218 - 232

Published: Feb. 9, 2023

Cyclodextrins have been widely employed for drug delivery systems (DDSs) in which drugs are selectively delivered to a target site the body. Recent interest has focused on construction of cyclodextrin-based nanoarchitectures that show sophisticated DDS functions. These precisely fabricated based three important features cyclodextrins, namely (1) preorganized three-dimensional molecular structure nanometer size, (2) easy chemical modification introduce functional groups, and (3) formation dynamic inclusion complexes with various guests water. With use photoirradiation, released from at designated timing. Alternatively, therapeutic nucleic acids stably protected site. The efficient CRISPR-Cas9 system gene editing was also successful. Even more complicated can be designed DDSs. Cyclodextrin-based highly promising future applications medicine, pharmaceutics, other relevant fields.

Language: Английский

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