Manganese‐Based Tumor Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(19)

Published: Sept. 19, 2022

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.

Language: Английский

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Co₃O₄/CoFe₂O₄ Hollow Nanocube Multifunctional Nanozyme with Oxygen Vacancies for Deep-Learning-Assisted Smartphone Biosensing and Organic Pollutant Degradation

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(9), P. 11787 - 11801

Published: Feb. 21, 2023

Although the application of nanozymes has been widely studied, it is still a huge challenge to develop highly active and multifunctional nanozyme catalysts with wider prospect. Co3O4/CoFe2O4 hollow nanocubes (HNCs) oxygen vacancies were proposed in this study, which had porous oxide heterostructure CoFe2O4 as core Co3O4 shell. The HNCs three enzyme activities: peroxidase-like, oxidase-like, catalase-like. Combining XPS depth profiling density functional theory (DFT), catalytic mechanism peroxidase-like activity was explored depth, mainly originated from ·OH produced by synergistic effect between outer inner electron transfer Co Fe. A colorimetry/smartphone dual sensing platform designed based on activity. Especially, intelligent deep learning-YOLO v3 algorithm-assisted smartphone constructed realize real-time rapid situ detection l-cysteine, norfloxacin, zearalenone. Surprisingly, limit norfloxacin low at 0.015 μM, better than that newly published method field nanozymes. Meanwhile, l-cysteine successfully investigated FTIR. In fact, also showed outstanding applications detecting food environment drugs. Furthermore, could degrade 99.24% rhodamine B, along good reusability even after 10-cycle runs. Therefore, work provided an in-depth understanding reaction efficient for establishing deep-learning-assisted platform. addition, research offered guideline further development construction multienzyme activities applications.

Language: Английский

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Metal–organic framework-engineered enzyme/nanozyme composites: Preparation, functionality, and sensing mechanisms

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153884 - 153884

Published: July 9, 2024

Language: Английский

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Advances in design and preparation of nanozymes and their applications for constructing higher sensitive lateral flow assays

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215797 - 215797

Published: April 4, 2024

Language: Английский

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Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

Small, Journal Year: 2022, Volume and Issue: 19(7)

Published: Dec. 13, 2022

Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity dysfunctionality complex pathological microenvironments. To overcome the impediments of substrate availabilities concentrations, some metal-based may mimic two or more activities natural enzymes to catalyze cascade reactions multiple substrates simultaneously, thereby amplifying catalysis. Metal-based with multienzyme-like (MNMs) adapt dissimilar conditions exert different enzyme-like effects. These can synergize realize "self-provision substrate," which upstream catalysts produce downstream limitation microenvironment. Consequently, MNMs potent antitumor, antibacterial, anti-inflammatory effects preclinical models. This review summarizes cellular underlying mechanisms MNMs. Their potential utility optimization strategy from perspective clinical requirements also discussed, aim provide a theoretical reference design, development, therapeutic application their

Language: Английский

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Nanoscale Zeolitic Imidazolate Framework (ZIF)–8 in Cancer Theranostics: Current Challenges and Prospects

Cancers, Journal Year: 2022, Volume and Issue: 14(16), P. 3935 - 3935

Published: Aug. 15, 2022

Cancer severely threatens human health and has remained the leading cause of disease–related death for decades. With rapid advancement nanomedicine, nanoscale metal–organic frameworks are believed to be potentially applied in treatment biomedical imaging various tumors. Zeolite imidazole framework (ZIF)–8 attracts increasing attention due its high porosity, large specific surface area, pH–responsiveness. The designs modifications ZIF–8 nanoparticles, as well strategy drug loading, demand a multifaceted comprehensive understanding nanomaterial features tumor characteristics. We searched studies on ZIF–8–based nanoplatforms theranostics Web Science from 2015 2022, mainly focused research published past 3 years, summarized progress their applications treatment, discussed favorable aspects nanoparticles future opportunities potential challenges. As kind material full potential, can expected combined with more therapeutic systems continue contribute all therapy diagnosis.

Language: Английский

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Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(21)

Published: Sept. 1, 2022

Manganese (Mn) has attracted widespread attention due to its low-cost, nontoxicity, and valence-rich transition. Various Mn-based nanomaterials have sprung up are employed in diverse fields, particularly nanozymes, which combine the physicochemical properties of with catalytic activity natural enzymes, attracting a surge research, especially field biomedical research. In this review, typical preparation strategies, mechanisms, advances perspectives nanozymes for applications systematically summarized. The application tumor therapy sensing detection, together an overview their mechanism action is highlighted. Finally, prospective directions from five perspectives: innovation, enhancement, selectivity, biocompatibility, broadening discussed.

Language: Английский

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Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Small Methods, Journal Year: 2023, Volume and Issue: 8(3)

Published: Nov. 23, 2023

Abstract Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, development recent progress various approaches briefly summarized. addition, interesting properties adjustable porosity, excellent thermal, chemical stabilities introduced. Further, five representative biomedical highlighted based on above physicochemical properties. Finally, remaining challenges offered insights into future outlook also discussed. This review aims understand co‐relationships between structures offering opportunity construct attractive materials promising characteristics.

Language: Английский

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Amelioration of systemic antitumor immune responses in cocktail therapy by immunomodulatory nanozymes

Science Advances, Journal Year: 2022, Volume and Issue: 8(21)

Published: May 27, 2022

Nanozymes that mimic natural enzyme–like activities have gradually emerged in cancer therapy. To overcome the bottlenecks of single-mode nanozymes, including “off-target” toxicity and ineffectiveness toward metastatic cancers, we designed magnetic nanoparticle–based multifunctional visualized immunomodulatory nanozymes. Besides partial initiation prime immune response by intrinsic immunogenicity, as a smart drug delivery system with temperature- pH-sensitive dual to tumor microenvironment, these nanozymes released agonists boost enhanced systemic response, eventually ameliorating microenvironment through many aspects: activating dendritic cells, improving function CD8 + T decreasing population myeloid-derived suppressor which inhibited both primary cancers. Mechanistically, regulated reactive oxygen species–related Akt signaling pathway consequently activated cell apoptosis–related pathways, provided deeper understanding synergistic mechanism Our findings offer promising imaging-guided cocktail therapy strategy

Language: Английский

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Recent progress of nanozymes with different spatial dimensions for bioanalysis

Materials Today Nano, Journal Year: 2023, Volume and Issue: 22, P. 100330 - 100330

Published: March 31, 2023

Language: Английский

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