Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e27433 - e27433
Published: March 1, 2024
Parkinson's
disease
is
a
neurodegenerative
condition
defined
by
the
progressive
death
of
dopaminergic
neurons
in
brain.
The
diagnosis
often
uses
time-consuming
clinical
evaluations
and
subjective
assessments.
Electrochemical
Impedance
Spectroscopy
(EIS)
useful
technique
for
electroanalytical
devices
due
to
its
label-free
performance,
in-situ
measurements,
low
cost.
development
reliable
diagnostic
tools
can
be
significantly
enhanced
exploring
novel
techniques
like
faradaic
non-faradaic
EIS
detection
methods.
These
have
ability
identify
specific
biomarkers
or
changes
electrochemical
properties
linked
disease,
allowing
an
early
accurate
diagnosis.
Faradaic
methods
utilize
redox
processes
on
electrode
surface,
while
rely
charge
transfer
capacitive
properties.
electrical
as
indicators
measuring
impedance
at
different
frequencies.
By
combining
both
approaches,
it
may
possible
obtain
comprehensive
understanding
occurring
patients.
This
lead
more
effective
potentially
opening
up
new
avenues
personalized
treatment
strategies.
review
explores
current
research
approaches
diagnosing
using
spectroscopy.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(3), P. 574 - 574
Published: Jan. 31, 2023
The
human
nature
of
curiosity,
wonder,
and
ingenuity
date
back
to
the
age
humankind.
In
parallel
with
our
history
civilization,
interest
in
scientific
approaches
unravel
mechanisms
underlying
natural
phenomena
has
been
developing.
Recent
years
have
witnessed
unprecedented
growth
research
area
pharmaceuticals
medicine.
optimism
that
nanotechnology
(NT)
applied
medicine
drugs
is
taking
serious
steps
bring
about
significant
advances
diagnosing,
treating,
preventing
disease-a
shift
from
fantasy
reality.
growing
future
medical
applications
NT
leads
emergence
a
new
field
for
nanomaterials
(NMs)
biomedicine.
recent
years,
NMs
emerged
as
essential
game
players
modern
medicine,
clinical
ranging
contrast
agents
imaging
carriers
drug
gene
delivery
into
tumors.
Indeed,
there
are
instances
where
nanoparticles
(NPs)
enable
analyses
therapies
cannot
be
performed
otherwise.
However,
NPs
also
unique
environmental
societal
challenges,
particularly
concerning
toxicity.
Thus,
should
revisited,
deep
understanding
effects
pathophysiologic
basis
disease
may
more
sophisticated
diagnostic
opportunities
yield
effective
preventive
features.
Correspondingly,
this
review
highlights
contributions
systems.
This
study
attempted
glimpse
impact
pharmaceuticals.
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(15), P. 7865 - 7865
Published: Aug. 5, 2022
This
review
summarizes
the
current
knowledge
on
and
future
applications
of
carbon
nanoparticles
in
medicine.
The
nanoparticle
family
has
a
large
number
representatives
with
unique
physicochemical
properties
that
make
them
good
candidates
for
use
clinical
best-known
(and
most
researched)
include
graphene,
graphene
oxide,
nanotubes.
main
direction
involves
medical
diagnostics,
which
includes
bioimaging
detection
chemicals
or
metabolites
present
body.
Since
question
toxicity
not
been
fully
answered,
fields
therapeutics
(drug
delivery),
regenerative
medicine
(cell
scaffolding,
tissue
engineering),
vaccine
production
is
still
under
research
many
vivo
studies
are
ongoing.
These
preclinical
suggest
have
great
potential
diagnosis
treatment;
results
show
used
do
significant
toxic
effects;
however,
caution
needed
before
introduced
into
routine
practice.
Biosensors and Bioelectronics X,
Journal Year:
2022,
Volume and Issue:
12, P. 100284 - 100284
Published: Nov. 25, 2022
The
recent
COVID-19
infection
outbreak
has
raised
the
demand
for
rapid,
highly
sensitive
POC
biosensing
technology
intelligent
health
and
wellness.
In
this
direction,
efforts
are
being
made
to
explore
high-performance
nano-systems
developing
novel
sensing
technologies
capable
of
functioning
at
point-of-care
(POC)
applications
quick
diagnosis,
data
acquisition,
disease
management.
A
combination
nanostructures
[i.e.,
0D
(nanoparticles
&
quantum
dots),
1D
(nanorods,
nanofibers,
nanopillars,
nanowires),
2D
(nanosheets,
nanoplates,
nanopores)
3D
nanomaterials
(nanocomposites
complex
hierarchical
structures)],
prototype,
micro-electronics
makes
suitable
early
detection
prevention
life-threatening
diseases.
However,
a
knowledge
gap
associated
with
potential
0D,
1D,
2D,
design
development
efficient
is
yet
be
explored
carefully
critically.
With
focus,
review
highlights
latest
engineered
next-generation
miniaturized,
portable
biosensors
achieve
high
sensitivity
integration
internet
medical
things
(IoMT,
miniaturization
collection,
security,
sharing),
artificial
intelligence
(AI,
desired
analytics),
etc.
better
diagnosis
management
personalized
level.
Abstract
A
proper
self‐regenerating
capability
is
lacking
in
human
cardiac
tissue
which
along
with
the
alarming
rate
of
deaths
associated
cardiovascular
disorders
makes
engineering
critical.
Novel
approaches
are
now
being
investigated
order
to
speedily
overcome
challenges
this
path.
Tissue
has
been
revolutionized
by
advent
nanomaterials,
and
later
application
carbon‐based
nanomaterials
because
their
exceptional
variable
functionality,
conductivity,
mechanical
properties.
Electrically
conductive
biomaterials
used
as
cell
bearers
provide
an
appropriate
microenvironment
for
specific
seeded
cells
substrates
sake
protecting
biological
media
against
attacking
mechanisms.
Nevertheless,
advantages
shortcoming
view
cellular
behavior,
toxicity,
targeted
delivery
depend
on
they
implanted
or
a
scaffold.
This
review
seeks
address,
summarize,
classify,
conceptualize,
discuss
use
nanoparticles
emphasizing
conductivity.
We
considered
electrical
conductivity
key
affecting
regeneration
cells.
Correspondingly,
we
reviewed
polymers
specifically
repair
high
efficiency.
comprehensively
classified
discussed
using
engineering.
An
overall
open
literature
electroactive
including
over
last
decade
was
provided,
tabulated,
thoroughly
discussed.
The
most
commonly
comprising
graphene,
graphene
oxide,
carbon
nanotubes,
nanofibers
were
studied.
Polymer Engineering and Science,
Journal Year:
2022,
Volume and Issue:
62(9), P. 2741 - 2749
Published: July 1, 2022
Abstract
Silk
fibroin
(SF)
has
been
broadly
applied
in
wound
dressing
fabrication
because
of
its
proper
features
for
healing.
In
this
work,
we
developed
a
carboxymethyl
cellulose
(CMC)/gelatin
blend
film
with
different
concentrations
glycerol,
and
modified
the
optimized
an
SF
layer
through
electrospinning
process.
Tensile
strength
cell
viability
evaluation
films
demonstrated
that
glycerol
content
3%
could
be
suitable
as
substrate
two‐layer
dressing.
The
morphology
electrospun
nanofibers
was
obtained
from
scanning
electron
microscopy
(SEM)
Fourier
transform
infrared
spectroscopy
(FTIR).
It
concluded
structural
changes
had
occurred
both
layers
after
cross‐linking
glutaraldehyde
vapor.
Further,
it
shown
mechanical
properties
enhanced
addition
SF.
Moreover,
swelling
ratio
higher
than
those
itself,
due
to
hydrophilic
property
CMC/gelatin
film.
biocompatibility
fibroblasts
investigated
by
MTT
assay,
coating
showed
improvement
proliferation
cytocompatibility
nature
All
results
suggest
prepared
desirable
candidate
healing
applications.
