Synlett,
Journal Year:
2024,
Volume and Issue:
35(08), P. 903 - 907
Published: Feb. 14, 2024
Abstract
The
manganese(I)-catalyzed
allylation
of
the
amino
acid
tryptophan
is
realized
under
exceedingly
mild
conditions
using
water
as
a
sustainable
and
non-hazardous
reaction
medium,
instead
classical
organic
solvents,
with
great
potential
for
green
chemistry.
Synthetically
useful
α,β-unsaturated
esters
can
be
accessed
by
Morita–Baylis–Hillman
(MBH)
adducts
following
fast
C–H
activation
approach.
robustness
this
procedure
reflected
kinetic
analysis
at
different
temperatures
reduced
catalyst
loadings
are
employed.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(19), P. 11269 - 11335
Published: Sept. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(29), P. 7782 - 7817
Published: Jan. 1, 2023
Peptide
and
protein
selective
modification
at
tyrosine
residues
has
become
an
exploding
field
of
research
as
constitutes
a
robust
alternative
to
lysine
cysteine-targeted
traditional
peptide/protein
protocols.
This
review
offers
comprehensive
summary
the
latest
advances
in
tyrosine-selective
cleavage,
functionalization,
conjugation
peptides
proteins
from
past
three
years.
updated
overview
complements
extensive
body
work
on
site-selective
proteins,
which
holds
significant
relevance
across
various
disciplines,
including
chemical,
biological,
medical,
material
sciences.
Green Synthesis and Catalysis,
Journal Year:
2023,
Volume and Issue:
4(2), P. 104 - 123
Published: Jan. 2, 2023
C–H
late-stage
functionalization
has
gradually
become
a
powerful
approach
for
the
rapid
optimization
of
lead
compounds'
bioactivity.
Significant
advances
in
this
field
have
been
achieved
past
few
years,
mainly,
system
(hetero)aryl
activation
owing
to
importance
moiety
pharmaceutical.
In
review,
we
described
selected
recent
examples
how
developed
intermolecular
C(sp2)–H
methodologies
involving
diverse
techniques
diversify
pharmaceutical
molecules
late
stage.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 18, 2024
Abstract
Peptide
aldehydes
are
crucial
biomolecules
essential
to
various
biological
systems,
driving
a
continuous
demand
for
efficient
synthesis
methods.
Herein,
we
develop
metal-free,
facile,
and
biocompatible
strategy
direct
electrochemical
of
unnatural
peptide
aldehydes.
This
electro-oxidative
approach
enabled
step-
atom-economical
ring-opening
via
C‒N
bond
cleavage,
allowing
homoproline-specific
diversification
expansion
substrate
scope
include
amides,
esters,
cyclic
amines
sizes.
The
remarkable
efficacy
the
electro-synthetic
protocol
set
stage
modification
assembly
linear
macrocyclic
peptides
using
concise
synthetic
sequence
with
racemization-free
conditions.
Moreover,
combination
experiments
density
functional
theory
(DFT)
calculations
indicates
that
different
N
-acyl
groups
play
decisive
role
in
reaction
activity.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(18), P. 6359 - 6378
Published: Jan. 1, 2023
This
review
discusses
the
important
role
of
silver(
i
)
salts
as
additives
in
transition-metal
catalyzed
C–H
activation,
and
depicts
discussion
about
current
shift
towards
Ag-free
procedures,
plausible
sustainable
alternatives.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(14)
Published: Feb. 7, 2024
Abstract
This
review
delves
into
the
innovative
field
of
interfacial
photoelectrochemical
(iPEC)
and
(PEC)
catalysis,
dynamic
synthesis
methodologies
that
seamlessly
integrates
electrochemical
photoredox
catalysis
for
efficient
environmentally
friendly
reactions.
Utilizing
minute
quantities
photocatalysts,
visible
light
becomes
a
powerful
tool,
generating
transient
excited
states
to
catalyze
spectrum
reactions
through
single‐electron
oxidation
or
reduction
events.
The
categorizes
recent
advancements,
highlighting
applications
in
organic
synthesis,
late‐stage
modifications,
distinctive
features
methodology.
Despite
being
its
early
stages,
this
synergistic
approach
holds
great
promise
propelling
forward,
with
potential
large‐scale
diverse
functionalizations,
including
asymmetric
bioconjugation
strategies
biomolecule
modifications.
ChemSusChem,
Journal Year:
2023,
Volume and Issue:
16(12)
Published: March 7, 2023
Electrochemically
promoted
transition
metal-catalyzed
C-H
functionalization
has
emerged
as
a
promising
area
of
research
over
the
last
few
decades.
However,
development
in
this
field
is
still
at
an
early
stage
compared
to
traditional
reactions
using
chemical-based
oxidizing
agents.
Recent
reports
have
shown
increased
attention
on
electrochemically
functionalization.
From
standpoint
sustainability,
environmental
friendliness,
and
cost
effectiveness,
oxidation
metal
catalyst
offers
mild,
efficient,
atom-economical
alternative
chemical
oxidants.
This
Review
discusses
advances
metal-electrocatalyzed
past
decade
describes
how
unique
features
electricity
enable
economic
sustainable
way.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
14(3), P. 604 - 612
Published: Dec. 3, 2022
Visible-light-mediated
methods
were
heavily
studied
as
a
useful
tool
for
cysteine-selective
bio-conjugation;
however,
many
current
suffer
from
bio-incompatible
reaction
conditions
and
slow
kinetics.
To
address
these
challenges,
herein,
we
report
transition
metal-free
thiol-sulfoxonium
ylide
photo-click
that
enables
bioconjugation
under
bio-compatible
conditions.
The
is
highly
generally
finished
within
minutes
with
naturally
occurring
riboflavin
derivatives
organic
photocatalysts.
catalysts
substrates
are
readily
accessible
bench
stable
have
satisfactory
water
solubility.
As
proof-of-concept
study,
the
was
smoothly
applied
in
chemo-proteomic
analysis,
which
provides
efficient
tools
to
explore
druggable
content
of
human
proteome.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(11)
Published: March 14, 2023
Abstract
The
combination
of
organometallic
C−H
activation
and
electro‐catalysis
has
emerged
as
a
potent
synthetic
technique
for
various
molecular
scaffolds
since
it
avoids
the
use
harmful
expensive
chemical
oxidants
in
stoichiometric
amounts.
Moreover,
pre‐functionalization
substrates
is
not
required
newer
ways
to
perform
metal‐catalyzed
reactions
are
possible.
Here,
we
have
discussed
eletrochemically
driven
acyloxylation,
acetoxylation,
oxygenation,
acylation,
amination,
alkylation,
halogenation,
olefinations
C−H/N−H
annulation
using
transition‐metal‐catalyst
such
Ru,
Rh,
Pd,
Co,
Ni,
Ir,
Cu,
Mn
Au
by
anodic
oxidation,
followed
reductive
elimination
form
corresponding
C−O,
C−C,
C−N
C−X
(X=Cl,
Br,
S
etc.)
bonds.
This
review
covers
recent
developments
transition‐metal‐catalyzed
electrochemical
from
2007
until
2022.
