Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Nov. 14, 2023
Biomaterials
are
extensively
used
to
mimic
cell-matrix
interactions,
which
essential
for
cell
growth,
function,
and
differentiation.
This
is
particularly
relevant
when
developing
in
vitro
disease
models
of
organs
rich
extracellular
matrix,
like
the
liver.
Liver
involves
a
chronic
wound-healing
response
with
formation
scar
tissue
known
as
fibrosis.
At
early
stages,
liver
can
be
reverted,
but
progresses,
reversion
no
longer
possible,
there
cure.
Research
new
therapies
hampered
by
lack
adequate
that
replicate
mechanical
properties
biochemical
stimuli
present
fibrotic
Fibrosis
associated
changes
composition
matrix
directly
influence
behavior.
could
play
an
role
better
emulating
microenvironment.
In
this
paper,
recent
cutting-edge
biomaterials
creating
human
fibrosis
revised,
combination
cells,
bioprinting,
and/or
microfluidics.
These
technologies
have
been
instrumental
intricate
structure
unhealthy
promote
medium
perfusion
improves
growth
respectively.
A
comprehensive
analysis
impact
material
hints
cell-material
interactions
tridimensional
context
provided.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(19)
Published: March 15, 2023
The
evolution
of
tissue
engineering
and
3D
bioprinting
has
allowed
for
increased
opportunities
to
generate
musculoskeletal
grafts
that
can
enhance
functional
aesthetic
outcomes
in
otolaryngology-head
neck
surgery.
Despite
literature
reporting
successes
the
fabrication
cartilage
bone
scaffolds
applications
head
neck,
full
potential
this
technology
yet
be
realized.
Otolaryngology
as
a
field
always
been
at
forefront
new
advancements
is
well
poised
spearhead
clinical
application
these
engineered
tissues.
In
review,
current
methods
are
described
an
overview
cell
types,
bioinks,
bioactive
factors
available
using
presented.
otologic,
nasal,
tracheal,
craniofacial
with
focus
on
graft
implantation
animal
models
highlight
status
vivo;
necessary
step
future
translation
reviewed.
Continued
multidisciplinary
efforts
between
material
chemistry,
biological
sciences,
otolaryngologists
will
play
key
role
engineered,
bioprinted
constructs
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(1), P. 255 - 255
Published: Jan. 11, 2023
The
fast-developing
field
of
3D
bio-printing
has
been
extensively
used
to
improve
the
usability
and
performance
scaffolds
filled
with
cells.
Over
last
few
decades,
a
variety
tissues
organs
including
skin,
blood
vessels,
hearts,
etc.,
have
all
produced
in
large
quantities
via
bio-printing.
These
are
not
only
able
serve
as
building
blocks
for
ultimate
goal
repair
regeneration,
but
they
can
also
be
utilized
vitro
models
pharmacokinetics,
drug
screening,
other
purposes.
To
further
3D-printing
uses
tissue
engineering,
research
on
novel,
suitable
biomaterials
quick
cross-linking
capabilities
is
prerequisite.
A
wider
acceptable
3D-printed
materials
still
needed,
well
better
printing
resolution
(particularly
at
nanoscale
range),
speed,
biomaterial
compatibility.
aim
this
study
provide
expertise
most
prevalent
new
an
introduction
associated
approaches
that
frequently
considered
by
researchers.
Furthermore,
effort
made
convey
pertinent
implementations
processes,
such
providing
significant
together
comprehensive
list
material
selection
guidelines,
constraints,
future
prospects.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 10, 2024
Traditional
tissue
engineering
methods
face
challenges,
such
as
fabrication,
implantation
of
irregularly
shaped
scaffolds,
and
limited
accessibility
for
immediate
healthcare
providers.
In
situ
bioprinting,
an
alternate
strategy,
involves
direct
deposition
biomaterials,
cells,
bioactive
factors
at
the
site,
facilitating
on-site
fabrication
intricate
tissue,
which
can
offer
a
patient-specific
personalized
approach
align
with
principles
precision
medicine.
It
be
applied
using
handled
device
robotic
arms
to
various
tissues,
including
skin,
bone,
cartilage,
muscle,
composite
tissues.
Bioinks,
critical
components
bioprinting
that
support
cell
viability
development,
play
crucial
role
in
success
bioprinting.
This
review
discusses
techniques,
materials
used
bioinks,
their
properties
successful
applications.
Finally,
we
discuss
challenges
future
trends
accelerating
printing
translate
this
technology
clinical
settings
regenerative
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: May 31, 2024
Abstract
3D
printing
of
articular
cartilage
tissue
faces
challenges
like
replicating
its
complex
structure,
time‐consuming
in
vitro
stem
cell
culture,
and
a
lack
robust
situ
regeneration
methods
for
osteochondral
defects
(OC).
In
response,
an
innovative
approach
utilizing
pre‐designed
bioink
modular
units
one‐step
immediate
implantation
is
proposed,
circumventing
the
need
prior
cultivation.
The
resulting
printed
scaffold
not
only
accurately
reproduces
three‐layer
structure
material
gradient
but
also
attains
impressive
compressive
strength
(6.3
MPa)
through
reinforcement
hydroxyapatite
nanofibers
establishment
chemical
bonds
with
hydrogels.
Moreover,
integrates
capturing
homing
layers
on
bottom
top
via
crosslinking
aptamer
loading
poly
(lactic‐co‐glycolic
acid)
(PLGA)
nanospheres
encapsulated
stromal
cell‐derived
factor‐1α
(SDF‐1α),
respectively.
This
design
enables
specific
capture
bone
marrow
mesenchymal
cells
(BMSCs)
vivo
interaction,
followed
by
their
mobilization
to
home
hyaline
layer
chemotaxis
SDF‐1α
concentration
gradient.
Within
scaffold's
microenvironment,
these
BMSCs
undergo
differentiation
into
distinct
each
layer,
effectively
contributing
repair
OC
rabbits.
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
354, P. 726 - 745
Published: Jan. 26, 2023
The
development
of
new
advanced
constructs
resembling
structural
and
functional
properties
human
organs
tissues
requires
a
deep
knowledge
the
morphological
biochemical
extracellular
matrices
(ECM),
capacity
to
reproduce
them.
Manufacturing
technologies
like
3D
printing
bioprinting
represent
valuable
tools
for
this
purpose.
This
review
will
describe
how
ECM
change
in
different
tissues,
organs,
healthy
pathological
states,
mimics
with
required
can
be
generated
by
bioprinting.
describes
classifies
polymeric
materials
natural
synthetic
origin
exploited
generate
hydrogels
acting
as
"inks"
process,
particular
emphasis
on
their
functionalization
allowing
crosslinking
conjugation
signaling
molecules
develop
bio-responsive
bio-instructive
mimics.
Biomedical Materials,
Journal Year:
2023,
Volume and Issue:
18(5), P. 052005 - 052005
Published: July 21, 2023
Abstract
The
field
of
neural
tissue
engineering
has
undergone
a
revolution
due
to
advancements
in
three-dimensional
(3D)
printing
technology.
This
technology
now
enables
the
creation
intricate
constructs
with
precise
geometries,
topologies,
and
mechanical
properties.
Currently,
there
are
various
3D
techniques
available,
such
as
stereolithography
digital
light
processing,
wide
range
materials
can
be
utilized,
including
hydrogels,
biopolymers,
synthetic
materials.
Furthermore,
development
four-dimensional
(4D)
gained
traction,
allowing
for
fabrication
structures
that
change
shape
over
time
using
shape-memory
polymers.
These
innovations
have
potential
facilitate
regeneration,
drug
screening,
disease
modeling,
hold
tremendous
promise
personalized
diagnostics,
therapeutic
strategies
against
brain
cancers.
review
paper
provides
comprehensive
overview
current
state-of-the-art
cancer.
It
focuses
on
exciting
possibilities
lie
ahead,
emerging
4D
printing.
Additionally,
discusses
applications
five-dimensional
six-dimensional
printing,
which
integrate
biological
functions
into
process,
fields
neuroscience.
Biosensors and Bioelectronics X,
Journal Year:
2024,
Volume and Issue:
18, P. 100480 - 100480
Published: April 25, 2024
Organ-on-a-Chip,
or
OOC,
is
a
widely
discussed
topic
in
science
due
to
its
many
unique
advantages
the
biomedical
field.
Nevertheless,
there
still
much
learn
about
OOC's
various
aspects
of
conception
and
significance
for
advancement
medical
technology
future.
A
platform
organs-on-a-chip
must
go
through
fabrication
process.
Various
manufacturing
processes
were
also
used
depending
on
required
disease
modelling
drug
screening.
Organs
chip
included
Brain-On-Chip,
Kidney-On-Chip,
Liver-On-Chip,
Heart-On-Chip.
In
order
provide
new
beginnings
with
thorough
understanding
we
have
studied
most
recent
developments
organ-on-a-chip
expertise
critically
assessed
relevant
features
this
research.
