Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 7, 2025
Metals
have
long
held
a
significant
role
in
the
human
body
and
been
utilized
as
mineral
medicines
for
thousands
of
years.
The
modern
advancement
metals
pharmacology,
particularly
metallodrugs,
has
become
crucial
disease
treatment.
As
machanism
metallodurgsare
increasingly
uncovered,
some
metallodrugs
are
already
approved
by
FDA
widely
used
treating
antitumor,
antidiabetes,
antibacterial.
Therefore,
thorough
understanding
metallodrug
development
is
essential
advancing
future
study.
This
review
offers
an
in-depth
examination
evolution
applications
within
contemporary
medicine.
We
specifically
aim
to
summarize
historical
trajectory
Traditional
Chinese
Mineral
Medicine
analyzing
key
texts
representative
medicines.
Additionally,
we
discuss
recent
advancements
metallodrugs'
mechanisms,
such
protein
interactions,
enzyme
inhibition,
DNA
reactive
oxygen
species
(ROS)
generation,
cellular
structure
targeting.
Furthermore,
address
challenges
propose
potential
solutions.
Lastly,
outline
directions
enhance
their
efficacy
effectiveness.
progression
broadened
contributed
significantly
patient
health,
creating
good
healthcare
solutions
global
population.
National Science Review,
Journal Year:
2024,
Volume and Issue:
11(9)
Published: July 18, 2024
ABSTRACT
The
spin
of
electrons
plays
a
vital
role
in
chemical
reactions
and
processes,
the
excited
state
generated
by
absorption
photons
shows
abundant
spin-related
phenomena.
However,
importance
electron
photochemistry
studies
has
been
rarely
mentioned
or
summarized.
In
this
review,
we
briefly
introduce
concept
based
on
multiplicity
state,
which
leads
to
observation
various
photophysical
properties
photochemical
reactivities.
Then,
focus
recent
advances
terms
light-induced
magnetic
properties,
excited-state
magneto-optical
effects
spin-dependent
reactions.
review
aims
provide
comprehensive
overview
utilize
manipulating
above
processes.
Finally,
discuss
existing
challenges
emerging
field
future
opportunities
such
as
smart
materials,
optical
information
technology
spin-enhanced
photocatalysis.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(42), P. 23257 - 23274
Published: Oct. 13, 2023
Phototheranostics
have
emerged
as
a
promising
subset
of
cancer
theranostics
owing
to
their
potential
provide
precise
photoinduced
diagnoses
and
therapeutic
outcomes.
However,
the
design
phototheranostics
remains
challenging
due
nature
tumors
microenvironment,
including
limitations
oxygen
supply,
high
rates
recurrence
metastasis,
immunosuppressive
state
cells.
Here
we
report
dual-functional
oxygen-independent
phototheranostic
agent,
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(17), P. 15606 - 15619
Published: Aug. 15, 2024
For
more
accurate
diagnosis
and
effective
treatment
of
cancer,
we
proposed
to
develop
a
hetero-multinuclear
metal
complex
based
on
the
property
apoferritin
(AFt)
for
targeting
tumor
theranostics
by
integrating
dual-modality
imaging
multimodality
therapy.
To
this
end,
rational
designed
synthesized
trinuclear
Gd(III)–Cu(II)
thiosemicarbazone
(Gd-2Cu)
then
constructed
Gd-2Cu@AFt
nanoparticle
(NP)
delivery
system.
Gd-2Cu/Gd-2Cu@AFt
NPs
not
only
had
significant
T1-weighted
magnetic
resonance
photoacoustic
but
also
effectively
inhibited
growth
through
combination
mild
photothermal
therapy,
chemotherapy,
immunotherapy.
optimized
behavior
therapy
Gd-2Cu,
improved
its
ability,
reduced
side
effects
in
vivo.
Besides,
revealed
clarified
anticancer
mechanism
Gd-2Cu:
interrupting
energy
metabolism
cell,
inducing
apoptosis
activating
systemic
immune
response
immunogenic
cell
death
cancer
cells.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(22), P. 15424 - 15436
Published: Nov. 13, 2023
For
the
integration
of
targeted
diagnosis
and
treatment
tumor,
we
innovatively
designed
synthesized
a
single-molecule
hetero-multinuclear
Er(III)–Cu(II)
complex
(ErCu2)
then
constructed
an
ErCu2@apoferritin
(AFt)
nanoparticle
(NP)
delivery
system.
ErCu2
ErCu2@AFt
NPs
not
only
provided
evident
photoacoustic
imaging
(PAI)
signal
tumor
but
also
effectively
inhibited
growth
by
integrating
photothermal
therapy,
chemotherapy,
immunotherapy.
improved
targeting
ability
decreased
systemic
toxicity
in
vivo.
Furthermore,
confirmed
that
inducing
apoptosis
autophagy
cells
activating
immune
The
study
provides
novel
strategy
to
develop
therapeutic
metal
agents
reveals
their
potential
for
accurate
multimodality
therapy
cancer.
