Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: Feb. 23, 2024
Abstract
Lipid
nanoparticles
(LNPs)
have
become
the
dominant
drug
delivery
technology
in
industry,
holding
promise
to
deliver
RNA
up
or
down‐regulate
any
protein
of
interest.
LNPs
mostly
been
targeted
specific
cell
types
organs
by
physicochemical
targeting
which
LNP’s
lipid
compositions
are
adjusted
find
mixtures
with
desired
tropism.
Here
lung‐tropic
examined,
whose
organ
tropism
derives
from
containing
either
a
cationic
ionizable
conferring
positive
zeta
potential.
Surprisingly,
these
found
induce
massive
thrombosis.
Such
thrombosis
is
shown
lungs
and
other
organs,
it
that
greatly
exacerbated
pre‐existing
inflammation.
This
clotting
induced
variety
formulations
lipids,
including
non‐LNP
nanoparticles,
even
lipids
do
not
permanent
charge.
The
mechanism
depends
on
binding
then
changing
conformation
fibrinogen,
activates
platelets
thrombin.
Based
mechanisms,
multiple
solutions
engineered
enable
positively
charged
target
while
ameliorating
findings
illustrate
how
approaches
must
be
investigated
early
for
risks
re‐engineered
careful
understanding
biological
mechanisms.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3876 - 3900
Published: June 22, 2024
Despite
the
promising
prospects
of
nanoparticles
in
oral
drug
delivery,
process
administration
involves
a
complex
transportation
pathway
that
includes
cellular
uptake,
intracellular
trafficking,
and
exocytosis
by
intestinal
epithelial
cells,
which
are
necessary
steps
for
to
enter
bloodstream
exert
therapeutic
effects.
Current
researchers
have
identified
several
crucial
factors
regulate
interaction
between
including
surface
properties
such
as
ligand
modification,
charge,
hydrophilicity/hydrophobicity,
protein
corona
formation,
well
holistic
like
particle
size,
shape,
rigidity.
Understanding
these
is
essential
enhancing
transepithelial
transport
efficiency
designing
effective
delivery
systems.
Therefore,
this
review
provides
comprehensive
overview
influence
nanoparticles,
elucidating
underlying
principles
governing
their
impact
on
transport.
The
also
outlines
chosen
parameters
be
considered
subsequent
design
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(9), P. 2270 - 2286
Published: Jan. 1, 2024
Breast
cancer
is
a
global
health
challenge
with
staggering
statistics
underscoring
its
pervasive
impact.
The
burden
of
this
disease
measured
in
terms
prevalence
and
the
challenges
it
poses
to
healthcare
systems,
necessitating
closer
look
at
epidemiology
Current
breast
treatments,
including
surgery,
chemotherapy,
radiation
therapy,
targeted
therapies,
have
made
significant
strides
improving
patient
outcomes.
However,
they
are
not
without
limitations,
often
leading
adverse
effects
development
drug
resistance.
This
comprehensive
review
delves
into
complex
landscape
cancer,
incidence,
current
treatment
modalities,
inherent
limitations
existing
therapeutic
approaches.
It
also
sheds
light
on
promising
role
nanotechnology,
encompassing
both
inorganic
organic
nanoparticles
equipped
ability
selectively
deliver
agents
tumor
sites,
battle
against
cancer.
addresses
emerging
their
associated
challenges,
future
prospects
delivery
management.
Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(9), P. 1494 - 1505
Published: March 15, 2024
RNA-based
therapeutics
have
gained
traction
for
the
prevention
and
treatment
of
a
variety
diseases.
However,
their
fragility
immunogenicity
necessitate
drug
carrier.
Lipid
nanoparticles
(LNPs)
emerged
as
predominant
delivery
vehicle
RNA
therapeutics.
An
important
component
LNPs
is
ionizable
lipid
(IL),
which
protonated
in
acidic
environment
endosome,
prompting
cargo
release
into
cytosol.
Currently,
there
growing
evidence
that
structure
IL
tails
significantly
impacts
efficacy
LNP-mediated
mRNA
translation.
Here,
we
optimized
tail
length
three
different
cargos.
Using
C12-200,
gold
standard
IL,
model,
designed
library
ILs
with
varying
lengths
evaluated
potency
vivo.
We
demonstrated
small
changes
lipophilicity
can
drastically
increase
or
decrease
identified
formulated
firefly
luciferase
(1929
base
pairs)
C10-200,
an
shorter
than
enhance
liver
transfection
by
over
10-fold.
Furthermore,
were
found
to
be
ideal
encapsulating
cargos
sizes.
erythropoietin
(EPO),
responsible
stimulating
red
blood
cell
production,
(858
pairs),
C13-200
led
EPO
translation
at
levels
similar
C12-200
LNP.
The
Cas9
(4521
C9-200
induced
times
quantity
indels
compared
Our
findings
suggest
may
lead
higher
larger
mRNAs,
longer
more
efficacious
delivering
smaller
envision
results
this
project
utilized
future
design
criteria
next
generation
LNP
systems
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(21), P. 2887 - 2887
Published: Oct. 31, 2023
Timely
diagnosis
and
appropriate
antitumoral
treatments
remain
of
utmost
importance,
since
cancer
remains
a
leading
cause
death
worldwide.
Within
this
context,
nanotechnology
offers
specific
benefits
in
terms
therapy
by
reducing
its
adverse
effects
guiding
drugs
to
selectively
target
cells.
In
comprehensive
review,
we
have
summarized
the
most
relevant
novel
outcomes
range
2010-2023,
covering
design
application
nanosystems
for
therapy.
We
established
general
requirements
nanoparticles
be
used
drug
delivery
strategies
their
uptake
tumor
microenvironment
vasculature,
including
reticuloendothelial
system
surface
functionalization
with
protein
corona.
After
brief
review
classes
nanovectors,
covered
different
therapies.
First,
advances
encapsulation
(such
as
paclitaxel
fisetin)
into
nanoliposomes
nanoemulsions
are
described,
well
relevance
current
clinical
trials.
Then,
polymeric
presented,
namely
ones
comprising
poly
lactic-co-glycolic
acid,
polyethylene
glycol
(and
PEG
dilemma)
dendrimers.
The
quantum
dots
bioimaging
is
also
covered,
systems
zinc
sulfide
indium
phosphide.
Afterwards,
reviewed
gold
(spheres
anisotropic)
plasmon-induced
photothermal
iron
oxide
nanoparticles,
such
magnetite
maghemite,
has
been
analyzed
fields,
magnetic
resonance
imaging,
immunotherapy,
hyperthermia,
delivery.
Lastly,
recent
using
carbon
nanomaterials,
graphene
oxide,
nanotubes,
fullerenes,
dots.
Finally,
compared
passive
active
targeting
theranostics.
This
aims
(nano)mark
on
ongoing
journey
towards
realizing
remarkable
potential
realm
therapeutics.
European Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
187, P. 106477 - 106477
Published: May 23, 2023
In
this
project,
drug
release
was
examined
based
on
the
adsorption
of
cisplatin,
carboplatin,
oxaliplatin,
and
oxalipalladium
aminated
mesoporous
silica
nanoparticles
(N-HMSNs)
human
serum
albumin
(HSA).
These
compounds
were
characterized
by
different
techniques
where
three
clinical
Pt-drugs,
plus
loaded
investigated
for
release.
Based
loading
analysis,
ability
mentioned
metallodrug
N-HMSNs
dependent
nature
structure
as
well
hydrophobic
or
hydrophilic
interactions.
Different
profiles
observed
all
via
dialysis
ICP
method
analysis.
Although
maximum
to
minimum
occurred
oxalipalladium,
oxaliplatin
respectively,
from
a
surface
with
greater
control
belonged
carboplatin
cisplatin
systems
in
absence
presence
HSA
48
h
due
weak
interaction
drug.
The
quick
protein
level
at
high
doses
during
chemotherapy
very
fast
within
first
6
h.
addition,
cytotoxic
activity
both
free
drugs
[email
protected]N-HMSNs
samples
cancerous
MCF-7,
HCT116,
A549,
normal
HFF
cell
lines
evaluated
MTT
assay.
It
found
that
metallodrugs
exhibited
more
active
behavior
than
protected]N-HMSNs.
Data
demonstrated
SI=6.0
6.6
MCF7
HCT116
lines,
SI=7.4
line
can
be
good
candidates
an
anticancer
minimal
side
effects
protecting
controlled
selectivity.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 4, 2024
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1232 - 1232
Published: Sept. 21, 2024
Silver
nanoparticles
(AgNPs)
are
leading
the
way
in
nanotechnological
innovation,
combining
captivating
properties
of
silver
with
accuracy
nanoscale
engineering,
thus
revolutionizing
material
science.
Three
main
techniques
arise
within
alchemical
domains
AgNP
genesis:
chemical,
physical,
and
biological
synthesis.
Each
possesses
its
distinct
form
magic
for
controlling
size,
shape,
scalability—key
factors
necessary
achieving
expertise
practical
application
nanoparticles.
The
story
unravels,
describing
careful
coordination
chemical
reduction,
environmentally
sensitive
charm
green
synthesis
utilizing
plant
extracts,
precise
physical
techniques.
AgNPs
highly
praised
field
healthcare
their
powerful
antibacterial
characteristics.
These
little
warriors
display
a
wide-ranging
attack
against
bacteria,
fungi,
parasites,
viruses.
Their
critical
significance
combating
hospital-acquired
surgical
site
infections
is
praised,
serving
as
beacon
hope
fight
challenging
problem
antibiotic
resistance.
In
addition
to
ability
kill
also
known
promote
tissue
regeneration
facilitate
wound
healing.
cancer
has
observed
adaptability
AgNPs.
review
documents
role
innovative
carriers
drugs,
specifically
designed
target
cells
accuracy,
minimizing
harm
healthy
tissues.
Additionally,
it
explores
potential
therapy
or
anticancer
agents
capable
disrupting
growth
tumors.
food
business,
utilized
enhance
durability
packing
materials
coatings
by
infusing
them
bactericidal
properties.
This
results
improved
safety
measures
significant
increase
duration
that
products
can
be
stored,
thereby
tackling
crucial
issue
preservation.
academic
analysis
recognizes
many
difficulties
come
creation
incorporation
statement
pertains
evaluation
environmental
effort
synthetic
processes.
predicts
future
pursuits,
envisioning
progress
will
usefulness
importance
from
being
new
becoming
essential
realms
science
industry.
Besides,
not
only
subject
scholarly
interest
but
component
continuous
tackle
some
most
urgent
health
conservation
concerns
contemporary
society.
aims
explore
complex
process
highlight
numerous
uses,
special
focus
on
growing
business
sectors.
invites
scientific
community
extensive
possibilities
order
fully
understand
utilize
potential.
