BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 5, 2024
Language: Английский
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 870 - 870
Published: Sept. 11, 2024
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against rising threat multidrug-resistant (MDR) bacteria. This comprehensive review explores historical context, modern resurgence phage and phage-facilitated advancements in medical technological fields. It details mechanisms action applications phages treating MDR particularly those associated with biofilms intracellular pathogens. The further highlights innovative uses vaccine development, cancer gene delivery vectors. Despite its targeted efficient approach, therapy faces challenges related stability, immune response, regulatory approval. By examining these areas detail, this underscores immense potential remaining hurdles integrating phage-based therapies into practices.
Language: Английский
Citations
17
Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e42013 - e42013
Published: Jan. 1, 2025
The issue of antimicrobial resistance (AMR) poses a major challenge to global health, evidenced by alarming mortality predictions and the diminishing efficiency conventional drugs. CRISPR-Cas system has proven be powerful tool in addressing this challenge. It originated from bacterial adaptive immune mechanisms gained significant recognition scientific community. This review aims explore applications technologies combating AMR, evaluating their effectiveness, challenges, potential for integration into current strategies. We conducted comprehensive recent literature databases such as PubMed Web Science, focusing on studies that employ against AMR. offer transformative approach combat with extend beyond traditional Integrating these existing methods could significantly enhance our ability manage potentially reverse growing problem resistance. Future research should address technical ethical barriers facilitate safe effective clinical environmental applications. underscores necessity interdisciplinary collaboration international cooperation harness full fight superbugs.
Language: Английский
Citations
2
Journal of Biomedical Materials Research Part A, Journal Year: 2023, Volume and Issue: 112(3), P. 312 - 335
Published: Oct. 26, 2023
Abstract Urinary catheters and other medical devices associated with the urinary tract such as stents are major contributors to nosocomial infections (UTIs) they provide an access path for pathogens enter bladder. Considering that catheter‐associated (CAUTIs) account approximately 75% of UTIs represent most common type healthcare‐associated infections, novel anti‐infective device technologies urgently required. The rapid rise antimicrobial resistance in context CAUTIs further highlights importance preventative strategies. In this review, risk factors pathogen colonization dissected, taking into nature mechanistics unique environment. Moreover, promising next‐generation strategies critically assessed, focusing particular on surface coatings. Finally, emerging approaches field their likely clinical impact examined.
Language: Английский
Citations
19
Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Facing the global "superbug" crisis due to emergence and selection for antibiotic resistance, phages are among most promising solutions. Fighting multidrug-resistant bacteria requires precise diagnosis of bacterial pathogens specific cell-killing. Phages have several potential advantages over conventional antibacterial agents such as host specificity, self-amplification, easy production, low toxicity well biofilm degradation. However, narrow range, uncharacterized properties, risks from exponential replication evolution natural phages, currently limit their applications. Engineering can not only enhance range improve phage efficacy, but also confer new functions. This review first summarizes major engineering techniques including both chemical modification genetic engineering. Subsequent sections discuss applications engineered pathogen detection ablation through interdisciplinary approaches synthetic biology nanotechnology. We future directions persistent challenges in ongoing exploration control.
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 374 - 374
Published: March 8, 2024
This review aims at presenting the main strategies that are currently available for delivery of bacteriophages to combat bacterial infections in humans, animals, and plants. It can be seen routes phage topical, oral, systemic, airways humans. In topical oral most used. To plant species, spraying plant’s phyllosphere or drenching soil commonly used methods. both therapy biocontrol using phages, very promising results have been obtained so far. However, more experiments needed establish forms treatment doses, among other parameters. Furthermore, general, there is a lack specific standards use phages infections.
Language: Английский
Citations
7
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: Nov. 15, 2023
Cancer is a devastating disease with high global mortality rate and projected to increase further in the coming years. Current treatment options, such as chemotherapy radiation therapy, have limitations including side effects, variable effectiveness, costs, limited availability. There growing need for alternative treatments that can target cancer cells specifically fewer effects. Phages, infect bacteria but not eukaryotic cells, emerged promising therapeutics due their unique properties, specificity ease of genetic modification. Engineered phages transform by targeting while sparing healthy ones. Phages exhibit versatility nanocarriers, capable delivering therapeutic agents like gene immunotherapy, vaccines. are extensively used vaccine development, filamentous, tailed, icosahedral explored different antigen expression possibilities. filamentous bring benefits built adjuvant cost-effectiveness, multivalent formulations, feasibility oral administration, stability. Phage-based vaccines stimulate innate immune system engaging pattern recognition receptors on antigen-presenting enhancing phage peptide presentation B-cells T-cells. This review presents recent therapy advances challenges exploring its versatile tools potential.
Language: Английский
Citations
14
Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(15), P. 22199 - 22242
Published: Feb. 27, 2024
Language: Английский
Citations
4
Infectious Medicine, Journal Year: 2025, Volume and Issue: 4(1), P. 100168 - 100168
Published: Feb. 6, 2025
Phages, including the viruses that lyse bacterial pathogens, offer unique therapeutic advantages, their capacity to antibiotic-resistant bacteria and disrupt biofilms without harming host microbiota. The lack of new effective antibiotics growing limitations existing have refocused attention on phage therapy as an option in complex clinical cases such burn wounds, cystic fibrosis, pneumonia. This review describes preclinical studies which has been both human veterinary medicine, agricultural context. In addition, critical challenges, narrow range bacteriophages, possibility resistance, regulatory constraints widespread use therapy, are addressed. Future directions include optimizing through strategies ranging from cocktails broadening genetic modification, using phages vaccines or biocontrol agents. future, if can be efficiently delivered, maintained a stable state, phage-antibiotic synergy achieved, will much needed treatment options. However, successful implementation within current standards practice also require considerable development infrastructure greater public acceptance. closing, this highlights promise backup substitute for antibiotics. It proposes role significant adjunct to, even replacement for, treating multidrug-resistant infections.
Language: Английский
Citations
0
Published: Aug. 27, 2024
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against rising threat multidrug-resistant (MDR) bacteria. This comprehensive review explores historical context, modern resurgence phage and phage-facilitated advancements in medical technological fields. It details mechanisms action applications phages treating MDR particularly those associated with biofilms intracellular pathogens. The further highlights innovative uses vaccine development, cancer gene delivery vectors. Despite its targeted efficient approach, therapy faces challenges related stability, immune response, regulatory approval. By examining these areas detail, this underscores immense potential remaining hurdles integrating phage-based therapies into practices.
Language: Английский
Citations
3
Chemistry International, Journal Year: 2023, Volume and Issue: 45(4), P. 14 - 22
Published: Oct. 1, 2023
Abstract This manuscript marks the five-year anniversary of IUPAC’s “Top Ten” initiative [1]. The new additions will grow list emerging technologies to fifty—all with a powerful potential make our world more sustainable and all suitable solutions current polycrisis [2]. past summer, theme IUPAC World Chemistry Congress in Hague was “Connecting Chemical Worlds,” which aligns almost perfectly goals Ten”—multidisciplinary research is key towards transitioning net-zero achieving United Nation’s Sustainable Development by 2030 [3]. Moreover, selection this year particularly promotes cross-collaboration chemistry create exciting that bridge gap between academia industry, while continuing competitiveness chemical manufacturers. From pool possible ideas, panel experts have selected following list, covering range fields from synthesis polymer health artificial intelligence. technology readiness level varies along different solutions—nevertheless, show provocative promise reimagine society.
Language: Английский
Citations
8