Towards bioresource-based aggregation-induced emission luminogens from lignin β-O-4 motifs as renewable resources DOI Creative Commons
Tenglong Guo, Yuting Lin, Deng Pan

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 28, 2023

One-pot synthesis of heterocyclic aromatics with good optical properties from phenolic β-O-4 lignin segments is high importance to meet value added biorefinery demands. However, executing this process remains a huge challenge due the incompatible reaction conditions depolymerization containing γ-OH functionalities and bioresource-based aggregation-induced emission luminogens (BioAIEgens) formation desired properties. In work, benzannulation reactions starting moieties 3-alkenylated indoles catalyzed by vanadium-based complexes have been successfully developed, affording wide range functionalized carbazoles up 92% yield. Experiments density functional theory calculations suggest that pathway involves selective cleavage double C-O bonds/Diels-Alder cycloaddition/dehydrogenative aromatization. Photophysical investigations show these carbazole products represent class BioAIEgens twisted intramolecular charge transfer. Distinctions behavior were revealed based on unique acceptor-donor-acceptor-type molecular conformations as well packings. This work features motifs renewable substrates, without need apply external oxidant/reductant systems. Here, we concise sustainable route AIE properties, building bridge between BioAIE materials.

Language: Английский

A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy DOI Creative Commons

Xiaoying Kang,

Yuan Zhang, Jianwen Song

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating high-performance paclitaxel (PTX) into nanoparticles, further camouflaging macrophage cell membrane, tumor-targeting theranostic agent is built. integration of PA imaging helps to delineate tumor site sensitively, providing accurate guidance light-induced PDT effect could consume local oxygen lead severer hypoxia, accelerating release PTX drug. As result, chemotherapy induces immunogenic death, which not only elicit antitumor immunity suppress primary tumor, but also inhibit growth distant in 4T1 tumor-bearing female mice. strategy develop agents rational molecular design boosting

Language: Английский

Citations

100
Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical DOI Creative Commons

Zijuan Meng,

Huiying Xue,

Tingting Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Language: Английский

Citations

83
An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation DOI
Yuwei Wang,

Jinghan Liao,

Yanting Lyu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(33)

Published: April 25, 2023

Abstract Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on biological microenvironment because it difficult produce type I and II reactive oxygen species (ROS) simultaneously. Herein, an electron‐rich anion‐ π + AIEgen Pys‐QM‐TT reported, which capable generating ROS realizing near‐infrared fluorescence imaging synchronously. In rational design photosensitizer, strong electron‐donating triphenylamine unit, π‐bridge thiophene electron‐withdrawing pyridinium salt unit can enhance D–π–A behavior, thereby improving intramolecular charge transfer extending wavelength. Meanwhile, powerful supposed reduce ∆ E S‐T promote intersystem crossing processes, thus increasing generation ROS. addition, negatively charged anion group provides environment for excited so as electron generate Therefore, not only simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections ablate tumor tissue by promoting cell apoptosis, inhibiting proliferation anti‐angiogenesis.

Language: Английский

Citations

77
Recent advances in small-molecule fluorescent probes for diagnosis of cancer cells/tissues DOI
Kun Wang, Caiyun Liu,

Hanchuang Zhu

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 477, P. 214946 - 214946

Published: Dec. 9, 2022

Language: Английский

Citations

70
Chemiluminescent carbon nanodots for dynamic and guided antibacteria DOI Creative Commons

Jiang‐Fan Han,

Qing Lou,

Zhong‐Zheng Ding

et al.

Light Science & Applications, Journal Year: 2023, Volume and Issue: 12(1)

Published: May 4, 2023

Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria. Image-guided therapy is one most promising strategies for efficiently and accurately curing bacterial infections. Herein, a chemiluminescence (CL)-dynamic/guided antibacteria (CDGA) with multiple reactive oxygen species (ROS) generation capacity chemiexcited near-infrared emission has been designed precise theranostics infection by employing emissive carbon nanodots (CDs) peroxalate as CL fuels. Mechanistically, hydrogen peroxide generated in microenvironment can trigger chemically initiated electron exchange between CDs energy-riched intermediate originated from oxidized peroxalate, enabling induced inflammation imaging. Meanwhile, type I/II photochemical ROS production III ultrafast charge transfer under self-illumination inhibit bacteria proliferation efficiently. The potential clinical utility CDGA further demonstrated infected mice trauma model. self-illuminating exhibits an excellent vivo imaging quality early detecting wound infections internal caused bacteria, proven efficient broad-spectrum nanomedicines without drug-resistance, whose sterilizing rate up 99.99%.

Language: Английский

Citations

66
An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐ and Immuno‐Therapy of Cancer DOI Open Access
Min Zhao, Yuyang Zhang,

Jia Miao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(4)

Published: Aug. 29, 2023

Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia-tolerant superiority over the commonly used II pathway. A few photosensitizers are exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity low-efficient theranostics. To resolve this issue, herein aminopeptidase N (APN)-activated phototheranostic probe (CyA) is reported for anti-hypoxic PDT in conjunction with immunotherapy treatment. CyA can specifically activate near-infrared fluorescence, photoacoustic signals, phototoxicity following APN-induced substrate cleavage subsequent generation active molecules (such CyBr). endows specific imaging capabilities toward cells overexpressing APN under both normoxia hypoxia. In addition, locally activatable induces systemic antitumor immune responses. More importantly, integration localized activated evokes enhanced therapeutic effects improved inhibition efficiency live mice compared individual treatments. This study aims to present combination therapy.

Language: Английский

Citations

62
Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia DOI
Bingli Lu, Lingyun Wang, Hao Tang

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4600 - 4618

Published: Jan. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Language: Английский

Citations

59
Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy DOI Creative Commons

Chonglu Li,

Le Tu,

Jingfang Yang

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(11), P. 2901 - 2909

Published: Jan. 1, 2023

Although metallacycle-based photosensitizers have attracted increasing attention in biomedicine, their clinical application has been hindered by inherent dark toxicity and unsatisfactory phototherapeutic efficiency. Herein, we employ a π-expansion strategy for ruthenium acceptors to develop series of Ru(ii) metallacycles (Ru1-Ru4), while simultaneously reducing enhancing phototoxicity, thus obtaining high phototoxicity index (PI). These enable deep-tissue (∼7 mm) fluorescence imaging reactive oxygen species (ROS) production exhibit remarkable anti-tumor activity even under hypoxic conditions. Notably, Ru4 the lowest toxicity, highest ROS generation ability an optimal PI (∼146). Theoretical calculations verify that exhibits largest steric bulk singlet-triplet energy gap (ΔEST, 0.62 eV). In vivo studies confirm allows effective safe phototherapy against A549 tumors. This work is expected open new avenue design high-performance metal-based potential applications.

Language: Английский

Citations

44
Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals DOI
Kun‐Xu Teng, Dongsheng Zhang,

Bin‐Kai Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 23, 2024

We herein present an approach of photo-induced disproportionation for preparation Type-I photodynamic agents. As a proof concept, BODIPY-based photosensitizers were rationally designed and prepared. The intermolecular electron transfer between homotypic chromophores leads to the reaction, resulting in formation charged intermediates, cationic anionic radicals. radicals efficiently oxidize cellularimportant coenzyme, tetrahydrobiopterin (BH

Language: Английский

Citations

43
Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives DOI Open Access

Jingai Jiang,

Xinyi Lv,

Huijuan Cheng

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19

Published: Feb. 7, 2024

Language: Английский

Citations

37