Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(37)
Published: May 22, 2024
Abstract
Though
platinum
(Pt)‐based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep‐seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near‐infrared
(NIR)
light‐activated
and
lysosomal
targeted
Pt(II)
metallacycle
(
1
)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
response
via
multiple‐regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth‐activated
ROS
production
(~7
mm),
accompanied
by
strong
anti‐diffusion
anti‐ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer‐oxaliplatin
(300
μM).
vivo
,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
+
/CD4
T
Foxp3
depletion
negligible
adverse
effects.
This
study
pioneers
promising
avenue
safe
metal‐based
agents
immunotherapy.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(13), P. 4392 - 4442
Published: Jan. 1, 2023
Metal
agents
have
made
incredible
strides
in
preclinical
research
and
clinical
applications,
but
their
short
emission/absorption
wavelengths
continue
to
be
a
barrier
distribution,
therapeutic
action,
visual
tracking,
efficacy
evaluation.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: March 8, 2024
Although
being
applied
as
photosensitizers
for
photodynamic
therapy,
covalent
organic
frameworks
(COFs)
fail
the
precise
fluorescence
imaging
in
vivo
and
phototherapy
deep-tissue,
due
to
short
excitation/emission
wavelengths.
Herein,
this
work
proposes
first
example
of
NIR-II
emissive
benzobisthiadiazole-based
COF-980.
Comparing
its
ligands,
structure
COF-980
can
more
efficiently
reducing
energy
gap
(ΔE
Chemical & Biomedical Imaging,
Journal Year:
2023,
Volume and Issue:
1(3), P. 220 - 233
Published: May 18, 2023
Organic
polymethine
fluorophores
with
emission
in
the
NIR-II
window
(1000–1700
nm)
are
receiving
enormous
attention
biomolecular
medicine
and
bioimaging,
attributed
to
high
absorption
coefficients,
bright
emission,
excellent
biocompatibility,
molecule
adjustability.
Recently,
researchers
have
devoted
significant
effort
designing
improving
making
notable
progress
fluorescence
imaging
performance.
This
review
summarizes
recent
developments
molecular
engineering
design
mentality
of
probes
highlights
their
extensive
bioimaging
biosensing
applications.
Furthermore,
we
elucidate
potential
challenges
perspectives
these
dyes
chemical
biomedicine
imaging,
which
may
stimulate
further
development
high-performance
dye
contrast
agents
for
future
clinical
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(37)
Published: May 22, 2024
Though
platinum
(Pt)-based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep-seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near-infrared
(NIR)
light-activated
and
lysosomal
targeted
Pt(II)
metallacycle
(1)
supramolecular
ICD
inducer.
1
synergistically
potentiates
immunomodulatory
response
via
multiple-regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth-activated
ROS
production
(~7
mm),
accompanied
by
strong
anti-diffusion
anti-ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer-oxaliplatin
(300
μM).
vivo,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
A
series
of
dinuclear
Ir(III)
complexes
have
been
constructed
for
enhanced
photodynamic
and
photothermal
therapy
(PDT
PTT)
cisplatin-resistant
non-small-cell
lung
cancer.
They
enter
cells
via
caveolar
endocytosis,
target
mitochondria
but
not
nuclear,
generate
both
singlet
oxygen
superoxide
anion,
release
heat
when
exposed
to
infrared
(IR)
irradiation,
thus
inducing
reactive
species
(ROS)-associated
cell
disruption
thermal
ablation.
The
IR-generated
ROS
can
further
activate
caspases,
triggering
apoptosis.
Additionally,
the
deplete
intracellular
glutathione,
lead
lipid
peroxidation,
induce
ferroptosis.
selected
complex
Small,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 23, 2024
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.
